Catalog No.
RHD45801
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
S1PR1, Sphingosine 1-phosphate receptor 1, Endothelial differentiation G-protein coupled receptor 1, EDG1, CHEDG1, Sphingosine 1-phosphate receptor Edg-1, S1P1, S1P receptor Edg-1, S1P receptor 1, CD363
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P21453
Applications
ELISA, FCM, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3F85
A guide to selecting high-performing antibodies for S1PR1 (UniProt ID: P21453) for use in western blot, immunoprecipitation, and immunofluorescence., PMID:40291769
ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage., PMID:40266369
CD44v, S1PR1, HER3, MET and cancer-associated amino acid transporters are promising targets for the pancreatic cancers characterized using mAb., PMID:39757718
S1PR1 modulators in multiple sclerosis: Efficacy, safety, comparison, and chemical structure insights., PMID:36758307
Targeting Immune Cell Trafficking - Insights From Research Models and Implications for Future IBD Therapy., PMID:34017333
Validation of a monoclonal antibody directed against the human sphingosine 1-phosphate receptor type 1., PMID:33359172
Development and characterization of sphingosine 1-phosphate receptor 1 monoclonal antibody suitable for cell imaging and biochemical studies of endogenous receptors., PMID:30845158
Preclinical study of the antitumor effect of sphingosine-1-phosphate receptor 1 antibody (S1PR1-antibody) against human breast cancer cells., PMID:29860604
Sphingosine 1-Phosphate Receptor 1 Signaling Maintains Endothelial Cell Barrier Function and Protects Against Immune Complex-Induced Vascular Injury., PMID:29781582
Novel treatments for inflammatory bowel disease., PMID:29223139
Sphingosine-1-phosphate (S1P) enhances glomerular endothelial cells activation mediated by anti-myeloperoxidase antibody-positive IgG., PMID:29168342
CD8αα intraepithelial lymphocytes arise from two main thymic precursors., PMID:28530714
Sphingosine-1-phosphate and its receptors in anti-neutrophil cytoplasmic antibody-associated vasculitis., PMID:28206609
Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney., PMID:27851911
Expression of functional sphingosine-1 phosphate receptor-1 is reduced by B cell receptor signaling and increased by inhibition of PI3 kinase δ but not SYK or BTK in chronic lymphocytic leukemia cells., PMID:25632006
Overexpression of sphingosine-1-phosphate receptor 1 and phospho-signal transducer and activator of transcription 3 is associated with poor prognosis in rituximab-treated diffuse large B-cell lymphomas., PMID:25472725
Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors., PMID:24810969
Evaluation of commercial antibodies against human sphingosine-1-phosphate receptor 1., PMID:24458374
Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models., PMID:23166225
New B-cell CD molecules., PMID:20933010
Cellular localization of sphingosine-1-phosphate receptor 1 expression in the human central nervous system., PMID:20566754
Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor., PMID:20348395
Expression of sphingosine-1-phosphate receptor 1 in mantle cell lymphoma., PMID:20081804
The expression level of sphingosine-1-phosphate receptor type 1 is related to MIB-1 labeling index and predicts survival of glioblastoma patients., PMID:19937366
Immunohistochemical detection of sphingosine-1-phosphate receptor 1 in vascular and lymphatic endothelial cells., PMID:18758970
For research use only. Not for human or drug use.
