Catalog No.
RHC32102
Species reactivity
Human, Rat
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, WB: 1:500-1:2000
Target
Medullasin, ELA2, ELANE, PMN elastase, Neutrophil elastase, HLE, Human leukocyte elastase, Elastase-2, Bone marrow serine protease
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P08246
Applications
ELISA, FCM, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3A65
Enzymatic, structural, and biophysical characterization of a single-domain antibody (VHH) selectively and tightly inhibiting neutrophil elastase and exhibiting favorable developability properties., PMID:39604162
Impact of different genetic mutations on granulocyte development and G-CSF responsiveness in congenital neutropenia., PMID:38286463
Congenital Neutropenia with ELANE Gene Mutation Complicated with MPO-ANCA Positivity., PMID:37782389
Ductular reaction-associated neutrophils promote biliary epithelium proliferation in chronic liver disease., PMID:37348790
Cyclic neutropenia and concomitant IgA nephropathy: a case report., PMID:37138249
Paediatric autoimmune diseases with ELANE mutations associated with neutropenia., PMID:37118811
A high prevalence of neutrophil-specific antibodies in ELANE-mutated severe congenital neutropenia., PMID:36734404
Neurobiochemical, Peptidomic, and Bioinformatic Approaches to Characterize Tauopathy Peptidome Biomarker Candidates in Experimental Mouse Model of Traumatic Brain Injury., PMID:36635478
Precise CRISPR-Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells., PMID:35658035
Dual intra- and extracellular release of monomethyl auristatin E from a neutrophil elastase-sensitive antibody-drug conjugate., PMID:34974337
Human Antibody Domains and Fragments Targeting Neutrophil Elastase as Candidate Therapeutics for Cancer and Inflammation-Related Diseases., PMID:34681796
Alirocumab treatment and neurocognitive function according to the CANTAB scale in patients at increased cardiovascular risk: A prospective, randomized, placebo-controlled study., PMID:34303265
Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19., PMID:33239231
Pyrexia and acidosis act independently of neutrophil elastase reactive center loop cleavage to effect cortisol release from corticosteroid-binding globulin., PMID:33085168
Antibody response against Pseudomonas aeruginosa and its relationship with immune mediators in the upper and lower airways of cystic fibrosis patients., PMID:32022432
Elastin-Specific Autoimmunity in Smokers With Thoracic Aortic Aneurysm and Dissection is Independent of Chronic Obstructive Pulmonary Disease., PMID:30957625
Infiltrating Myeloid Cells Exert Protumorigenic Actions via Neutrophil Elastase., PMID:28512253
Yeast product supplementation modulated humoral and mucosal immunity and uterine inflammatory signals in transition dairy cows., PMID:25726103
Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia., PMID:23206890
For research use only. Not for human or drug use.
