Catalog No.
YHD27801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe352-Cys656
Predicted molecular weight
36.91 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P18054
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
12LO, 12S-LOX, Arachidonate (12S)-lipoxygenase, Platelet-type lipoxygenase 12, LOG12, Arachidonate (15S)-lipoxygenase, Lipoxin synthase 12-LO, Linoleate (13S)-lipoxygenase, 12S-lipoxygenase, ALOX12, Polyunsaturated fatty acid lipoxygenase ALOX12
Sevoflurane exposure triggers ferroptosis of neuronal cells initiated by the activation of ATM/p53 in the neonatal mouse brain via JNK/p38 MAPK-mediated oxidative DNA damage., PMID:40378436
Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) Induces Ferroptosis in Rat Cortical Neurons via p53-SLC7A11-ALOX12/p53-SAT1-ALOX15 Pathways., PMID:40288885
Euphorbia humifusa Willd. ex Schltdl. Mitigates Liver Injury via KEAP1-NFE2L2-Mediated Ferroptosis Regulation: Network Pharmacology and Experimental Validation., PMID:40284852
12-Lipoxygenase Inhibition Improves Glycemia and Obesity-associated Inflammation in Male Human Gene Replacement Mice., PMID:40186458
The potential effective components from Danlou tablet attenuates acute myocardial infarction by restoring ALOX12-mediated perturbed oxylipins., PMID:40086610
Association of Arachidonic Acid Metabolism Related Genes With Endometrial Immune Microenvironment and Oxidative Stress in Coupes With Recurrent Implantation Failure., PMID:39803797
Deeply Saddening Life Events Play a Carcinogenic Role by Inducing Mutations in ALOX12 and FKBP5 Genes., PMID:39766798
Unveiling the substantial role of rutin in the management of drug-induced nephropathy using network pharmacology and molecular docking., PMID:39733639
A high seizure burden increases brain concentrations of specialized pro-resolving mediators in the Scn1a+/- mouse model of Dravet syndrome., PMID:39701411
Rutin attenuates zearalenone-induced ferroptosis of endometrial stromal cells in piglets through the p53 signaling pathway., PMID:39700772
Revealing the core active pharmaceutical ingredients and targets of Jie-gu capsules for fracture treatment through network pharmacology and mendelian randomization., PMID:39654220
Structural and Functional Biology of Mammalian ALOX Isoforms with Particular Emphasis on Enzyme Dimerization and Their Allosteric Properties., PMID:39596127
Initial Exploration of the In Vitro Activation of GLP-1 and GIP Receptors and Pancreatic Islet Cell Protection by Salmon-Derived Bioactive Peptides., PMID:39590770
12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice., PMID:39531315
Menaquinone-4 Alleviates Sepsis-Associated Acute Lung Injury via Activating SIRT3-p53/SLC7A11 Pathway., PMID:39469061
Upregulation of ALOX12-12-HETE pathway impairs AMPK-dependent modulation of vascular metabolism in ApoE/LDLR-/- mice., PMID:39448044
Eicosanoid biosynthesizing enzymes in Prototheria., PMID:39389415
Palmitic acid inhibits macrophage-mediated chemotherapy resistance in multiple myeloma via ALOX12 signaling., PMID:39378653
Long-term thermal acclimation enhances heat resistance of Hong Kong catfish (Clarias fuscus) by modulating gill tissue structure, antioxidant capacity and immune metabolic pathways., PMID:39205351
Shexiang Tongxin dropping pill ameliorates microvascular obstruction via downregulating ALOX12 after myocardial ischemia-reperfusion., PMID:39179033
CX-5461 ameliorates disease in lupus-prone mice by triggering B-cell ferroptosis via p53-SLC7A11-ALOX12 pathway., PMID:39111584
Induction of ferroptosis by brucine suppresses gastric cancer progression through the p53-mediated SLCA711/ALOX12 axis., PMID:39050447
Varying the ratio of Lys: Met through enhancing methionine supplementation improved milk secretion ability through regulating the mRNA expression in bovine mammary epithelial cells under heat stress., PMID:38983772
The involvement of IRP2-induced ferroptosis through the p53-SLC7A11-ALOX12 pathway in Parkinson's disease., PMID:38936518
DNA methylation and stroke prognosis: an epigenome-wide association study., PMID:38845005
Baicalein alleviates cisplatin-induced acute kidney injury by inhibiting ALOX12-dependent ferroptosis., PMID:38805781
Luteolin attenuates CCl4-induced hepatic injury by inhibiting ferroptosis via SLC7A11., PMID:38755566
Enhanced ALOX12 Gene Expression Predicts Therapeutic Susceptibility to 5-Azacytidine in Patients with Myelodysplastic Syndromes., PMID:38731802
SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxidation., PMID:38516826
Loss of 15-Lipoxygenase in Retinodegenerative RCS Rats., PMID:38396985
Elevated ALOX12 in renal tissue predicts progression in diabetic kidney disease., PMID:38345057
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression., PMID:38309267
Polymorphisms in Cyclooxygenase, Lipoxygenase, and TP53 Genes Predict Colorectal Polyp Risk Reduction by Aspirin in the seAFOod Polyp Prevention Trial., PMID:37756582
Fructus Lycii and Salvia miltiorrhiza Bunge extract attenuate oxidative stress-induced photoreceptor ferroptosis in retinitis pigmentosa., PMID:37741257
Ribosomal protein control of hematopoietic stem cell transformation through direct, non-canonical regulation of metabolism., PMID:37398007
Ferroptosis is involved in polymyxin B-induced acute kidney injury via activation of p53., PMID:37088170
Hydroperoxidation of Docosahexaenoic Acid by Human ALOX12 and pigALOX15-mini-LOX., PMID:37047037
Ferroptosis of brain microvascular endothelial cells contributes to hypoxia-induced blood-brain barrier injury., PMID:37043308
WFDC12-overexpressing contributes to the development of atopic dermatitis via accelerating ALOX12/15 metabolism and PAF accumulation., PMID:36882395
Angiotensin II-induced vascular endothelial cells ferroptosis via P53-ALOX12 signal axis., PMID:36860117
Landscape of pathogenic mutations in premature ovarian insufficiency., PMID:36732629
Effect of atorvastatin on lipoxygenase pathway-related gene expression in an in vitro model of lipid accumulation in hepatocytes., PMID:36637998
The role of selenoproteins in neutrophils during inflammation., PMID:36336122
Biology and pharmacology of platelet-type 12-lipoxygenase in platelets, cancer cells, and their crosstalk., PMID:36130648
Growth State-Dependent Expression of Arachidonate Lipoxygenases in the Human Endothelial Cell Line EA.hy926., PMID:36010555
ALOX12: A Novel Insight in Bevacizumab Response, Immunotherapy Effect, and Prognosis of Colorectal Cancer., PMID:35833141
Chronic social defeat stress increases the amounts of 12-lipoxygenase lipid metabolites in the nucleus accumbens of stress-resilient mice., PMID:35790870
Dihydroartemisinin inhibits the growth of pancreatic cells by inducing ferroptosis and activating antitumor immunity., PMID:35569552
Modulation of gentamicin-induced acute kidney injury by myo-inositol oxygenase via the ROS/ALOX-12/12-HETE/GPR31 signaling pathway., PMID:35315361
Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators-What is the Evidence so far?, PMID:35308198
For research use only. Not for human or drug use.
