Catalog No.
YHD22401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Cys202
Predicted molecular weight
49.17 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P17081
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Rho-related GTP-binding protein RhoQ, ARHQ, RHOQ, RASL7A, Ras-like protein family member 7A, TC10, Ras-like protein TC10
TC10 on endosomes regulates the local balance between microtubule stability and dynamics through the PAK2-JNK pathway and promotes axon outgrowth., PMID:40008675
Loss of Cathepsin K impairs collagen biogenesis and enhances actin polymerization in trabecular meshwork., PMID:39990379
Interpretable machine learning-driven biomarker identification and validation for Alzheimer's disease., PMID:39730451
[Clinical pathological and genetic mutation characteristics of conjunctival lymphoepithelial carcinoma]., PMID:38199770
Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro., PMID:37079638
Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer., PMID:37026468
Alzheimer's disease large-scale gene expression portrait identifies exercise as the top theoretical treatment., PMID:36229643
Knockdown of RhoQ, a member of Rho GTPase, accelerates TGF-β-induced EMT in human lung adenocarcinoma., PMID:36120491
Differential modulation of collybistin conformational dynamics by the closely related GTPases Cdc42 and TC10., PMID:35989712
Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer., PMID:35385746
Effect of cadmium on Rho GTPases signal transduction during osteoclast differentiation., PMID:35257471
TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia., PMID:34531530
Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation., PMID:34000990
TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron-autonomous manner., PMID:33156548
Reelin activates the small GTPase TC10 and VAMP7 to promote neurite outgrowth and regeneration of dorsal root ganglia (DRG) neurons., PMID:32652719
RHOQ is induced by DLL4 and regulates angiogenesis by determining the intracellular route of the Notch intracellular domain., PMID:32506201
RhoJ Regulates α5β1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis., PMID:32302585
A GTPase-induced switch in phospholipid affinity of collybistin contributes to synaptic gephyrin clustering., PMID:31932505
The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation., PMID:31747610
Investigation of leukocyte RHO/ROCK gene expressions in patients with non-valvular atrial fibrillation., PMID:31572525
Identification of key genes and pathways between type I and type II endometrial cancer using bioinformatics analysis., PMID:31452737
The guanine nucleotide exchange factor Arhgef7/βPix promotes axon formation upstream of TC10., PMID:29891904
Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus., PMID:29670091
cAMP-induced activation of protein kinase A and p190B RhoGAP mediates down-regulation of TC10 activity at the plasma membrane and neurite outgrowth., PMID:29072354
The Small Rho GTPase TC10 Modulates B Cell Immune Responses., PMID:28747344
Detection of Critical Genes Associated with Overall Survival (OS) and Progression-Free Survival (PFS) in Reconstructed Canine B-Cell Lymphoma Gene Regulatory Network (GRN)., PMID:26818715
Synaptic activity regulates AMPA receptor trafficking through different recycling pathways., PMID:25970033
Lipid binding defects and perturbed synaptogenic activity of a Collybistin R290H mutant that causes epilepsy and intellectual disability., PMID:25678704
Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension., PMID:25361553
Analysis of intervertebral disc-related genes., PMID:24737428
Local translation of TC10 is required for membrane expansion during axon outgrowth., PMID:24667291
RNA editing in RHOQ promotes invasion potential in colorectal cancer., PMID:24663214
Genome-wide association studies identified novel loci for non-high-density lipoprotein cholesterol and its postprandial lipemic response., PMID:24604477
IQGAP1 is a key node within the small GTPase network., PMID:24355937
Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission., PMID:24297911
GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70., PMID:24223996
Severe growth retardation, delayed bone age, and facial dysmorphism in two patients with microduplications in 2p16 → p22., PMID:24115558
Insulin-like growth factor 1 (IGF-1) enhances the protein expression of CFTR., PMID:23555857
Fibronectin-induced VEGF receptor and calcium channel transactivation stimulate GLUT-1 synthesis and trafficking through PPARγ and TC10 in mouse embryonic stem cells., PMID:23455393
Rho GTPase expression in human myeloid cells., PMID:22916134
TC10 is regulated by caveolin in 3T3-L1 adipocytes., PMID:22900022
Cyclin-dependent kinase-5 is a key molecule in tumor necrosis factor-α-induced insulin resistance., PMID:21813649
Progesterone inhibits glucose uptake by affecting diverse steps of insulin signaling in 3T3-L1 adipocytes., PMID:20071559
The TC10-Exo70 complex is essential for membrane expansion and axonal specification in developing neurons., PMID:19846717
Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5., PMID:19713215
Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary fibroblast migration during platelet-derived growth factor-dependent chemotaxis., PMID:19273601
TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin., PMID:19258391
CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation., PMID:18948252
Activation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscle., PMID:18702941
Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5., PMID:18434594
For research use only. Not for human or drug use.
