Catalog No.
YHD12101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly134-Asn503
Predicted molecular weight
69.01 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P15538
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CYP11B1, Cytochrome P-450c11, Steroid 11-beta-hydroxylase, CYP11B1, Cytochrome P450C11, CYPXIB1, Cytochrome P450 11B1, mitochondrial, S11BH
Acquired 11β-Hydroxylase deficiency in etomidate and (Iso)propoxate abusers: A nascent endocrine condition., PMID:40451601
Toxicological profiling and diuretic potential of arbutin via aldosterone synthase gene inhibition., PMID:40280300
A CRISPR-based high-throughput screening system identifies bromodomain inhibitors as transcriptional suppressors of CYP11B1., PMID:40215680
Continuous flow-through steady state system for in vitro characterization of CYP11B2 inhibitors-Impact on enzyme kinetics of steroidogenesis., PMID:40101886
Long-term effects of maternal protein restriction on adrenal proteomic profile and steroidogenesis in male offspring rats., PMID:40032160
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: clinical, biochemical and molecular characteristics and long-term outcomes., PMID:39952853
High clinical utility of long-read sequencing for precise diagnosis of congenital adrenal hyperplasia in 322 probands., PMID:39810276
Rare Types of Congenital Adrenal Hyperplasias Other Than 21-hydroxylase Deficiency., PMID:39713884
Molecular characterization of archival adrenal tumor tissue from patients with ACTH-independent Cushing syndrome., PMID:39709101
Effects of the combination of Epimedium brevicornum Maxim, Ligustrum lucidum Ait and Dexamethasone on asthmatic rats by endogenous glucocorticoid pathway., PMID:39694426
Aldosterone Synthase Inhibitors: A Revival for Treatment of Renal and Cardiovascular Diseases., PMID:39656736
Clinical comparison and genetic analysis in pheochromocytoma with primary aldosteronism., PMID:39603607
Epigenomic Alterations of the Human CYP11B Gene in Adrenal Zonation., PMID:39596027
Impact of gonadotropin on certain testis-related genes identified through testicular transcriptome analysis in the Asian and the African catfish., PMID:39520808
Targeted long-read sequencing identifies missing pathogenic variant in unsolved 11β-hydroxylase deficiency., PMID:39402525
Immunohistochemical expression of CYP11A1, CYP11B, CYP17, and HSD3B2 in functional and nonfunctional canine adrenocortical tumors., PMID:39387578
Mineralocorticoid receptor antagonist monotherapy in pediatric non-classical 11β-hydroxylase deficiency., PMID:39295130
Androgen production, uptake, and conversion (APUC) genes define prostate cancer patients with distinct clinical outcomes., PMID:39207857
First-in-human study evaluating safety, pharmacokinetics, and pharmacodynamics of lorundrostat, a novel and highly selective aldosterone synthase inhibitor., PMID:39152532
Time-of-Day Adrenal Modulation of Corticosterone Synthesis is Affected by Sex and Diet but Not by Proanthocyanidins in Rat., PMID:39148153
Adrenodoxin allosterically alters human cytochrome P450 11B enzymes to accelerate substrate binding and decelerate release., PMID:39129792
Rare correlation of somatic PRKACA mutations with pregnancy-associated aldosterone- and cortisol-producing adenomas: a case report and literature review., PMID:39010034
Double CYP11B1/CYP11B2 Immunohistochemistry and Detection of KCNJ5 Mutations in Primary Aldosteronism., PMID:38888173
Human Gonads Do Not Contribute to the Circulating Pool of 11-Oxygenated Androgens., PMID:38885296
[Analysis of a family with 11β-hydroxylase deficiency due to a mutation in the CYP11B1 gene]., PMID:38858218
Identification of sulfonylpyrimidines as novel selective aldosterone synthase (CYP11B2) inhibitors., PMID:38851000
Emerging trends in small molecule inhibitors targeting aldosterone synthase: A new paradigm in cardiovascular disease treatment., PMID:38820853
The 3D in vitro Adrenoid cell model recapitulates the complexity of the adrenal gland., PMID:38580769
Kinetics of Intermediate Release Enhances P450 11B2-Catalyzed Aldosterone Synthesis., PMID:38564530
Non-classical 11β-hydroxylase deficiency caused by a novel heterozygous mutation: a case report and review of the literature., PMID:38411873
Chimeric Genes Causing 11β-Hydroxylase Deficiency: Implications in Clinical and Molecular Diagnosis., PMID:38324138
11β Hydroxylase Deficiency in a Child with Hypothyroidism: A Case Report., PMID:38289749
Identification and functional characterization of compound heterozygous CYP11B1 gene mutations., PMID:38285409
The intrafollicular concentrations of biologically active cortisol in women rise abruptly shortly before ovulation and follicular rupture., PMID:38268234
Histopathological analysis of tumor microenvironment in adrenocortical carcinoma: Possible effects of in situ disorganized glucocorticoid production on tumor immunity., PMID:38232786
Perfluorotetradecanoic acid exposure to adult male rats stimulates corticosterone biosynthesis but inhibits aldosterone production., PMID:38205621
Quantitative Characterization of Ectopic Adrenal Gene Expression in Fetal Testes in 21-Hydroxylase Deficient Mice., PMID:38171371
Aldosterone and aldosterone synthase inhibitors in cardiorenal disease., PMID:38133623
Prolonged adrenal insufficiency following discontinuation of osilodrostat treatment for intense hypercortisolism., PMID:38123490
Clinical Presentation and Genetic Analysis of Neonatal 11β-Hydroxylase Deficiency Induced by a Chimeric CYP11B2/CYP11B1 Gene., PMID:38088752
Clinical Features of Unrecognized Congenital Adrenal Hyperplasia Due to 17α-hydroxylase Deficiency Since Adolescence: A Case Report., PMID:38045661
Case Report: A combination of chimeric CYP11B2/CYP11B1 and a novel p.Val68Gly CYP11B1 variant causing 11β-Hydroxylase deficiency in a Chinese patient., PMID:38027139
Bilateral co-secretory lesions presenting with coexisting Cushing syndrome and primary aldosteronism: a case report., PMID:38017509
Sex differences in offspring risk and resilience following 11β-hydroxylase antagonism in a rodent model of maternal immune activation., PMID:38007547
A common germline variant in CYP11B1 is associated with adverse clinical outcome of treatment with abiraterone or enzalutamide., PMID:37988848
The mystery of transient pregnancy-induced cushing's syndrome: a case report and literature review highlighting GNAS somatic mutations and LHCGR overexpression., PMID:37828397
Structural and clinical characterization of CYP11B2 inhibition by dexfadrostat phosphate., PMID:37827219
Fluorinated aldosterone synthase (CYP11B2)-inhibitors for differential diagnosis between bilateral and unilateral conditions of primary aldosteronism., PMID:37804995
Generation of human steroidogenic cytochrome P450 enzymes for structural and functional characterization., PMID:37802575
Pathology and gene mutations of aldosterone-producing lesions., PMID:37766569
For research use only. Not for human or drug use.
