Catalog No.
MHD75201
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Immunogen
Recombinant Human Calreticulin/CALR.
Tested applications
ELISA: 1:1000-1:10000, WB: 1:500-1:2000
Endotoxin level
Please contact with the lab for this information.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P27797
Applications
FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Alternative Names
Calreticulin, ERp60, CRTC, Calregulin, grp60, HACBP, Endoplasmic reticulum resident protein 60, CALR, CRP55
Clone ID
m1A04
Generation of a Synthetic Single Domain Antibody Library for Radiopharmaceutical Ligand Discovery., PMID:40463173
Patritumab deruxtecan induces immunogenic cell death., PMID:40458967
Defective neutrophil clearance in JAK2V617F myeloproliferative neoplasms drives myelofibrosis via immune checkpoint CD24., PMID:40373279
The anti-FRα antibody-drug conjugate luveltamab tazevibulin demonstrates efficacy in non-small cell lung cancer preclinical models and induces immunogenic cell death., PMID:40293943
Synergistic Induction of Immunogenic Cell Death by Biomineralized Manganese and Bisphosphonates Enhances Anti-PD-L1 Therapy in Triple-Negative Breast Cancer., PMID:40276640
LGALS3BP antibody-drug conjugate enhances tumor-infiltrating lymphocytes and synergizes with immunotherapy to restrain neuroblastoma growth., PMID:40217513
PD-L1 targeted antibody-polymer-Epirubicin conjugate prolongs survival in a preclinical murine model of advanced ovarian cancer., PMID:40185333
Dual blockade of GSTK1 and CD47 improves macrophage-mediated phagocytosis on cancer cells., PMID:40147800
CALR-mutated myeloproliferative neoplasms., PMID:39960832
[Immunohistochemical method of megakaryocytic lineage staining in bone marrow biopsy specimens as an additional pathomorphological differential diagnostic sign of primary myelofibrosis and essential thrombocythemia]., PMID:39943725
Mutant Calreticulin in MPN: Mechanistic Insights and Therapeutic Implications., PMID:39775969
Anaplastic Lymphoma Kinase (ALK) Inhibitors Enhance Phagocytosis Induced by CD47 Blockade in Sensitive and Resistant ALK-Driven Malignancies., PMID:39767726
A non-invasive model for diagnosis of primary Sjogren's disease based on salivary biomarkers, serum autoantibodies, and Schirmer's test., PMID:39695856
Novel approaches in myelofibrosis., PMID:39670187
FVIIa-PAR2 signaling facilitates immune escape by reducing phagocytic potential of macrophages in breast cancer., PMID:39667690
INCA033989: the first shot on goal for MPNs?, PMID:39607716
Discovery of an theranostic functional mAb for visualizing the sensitivity and effectiveness of PD-L1 checkpoint therapy., PMID:39603072
CD47 and Calreticulin Expression in Breast Cancer Subtypes and Anti-CD47 Inhibitory Effects in Macrophage-mediated Phagocytosis., PMID:39477308
Epigallocatechin-3-gallate induces immunogenic cell death and enhances cancer immunotherapy in colorectal cancer., PMID:39471680
New approaches to standard of care in early-phase myeloproliferative neoplasms: can interferon-α alter the natural history of the disease?, PMID:39445431
Dendritic Cells Loaded With Heat Shock Inactivated Glioma Stem Cells Enhance Antitumor Response of Mouse Glioma When Combining With CD47 Blockade., PMID:39429684
Reprogramming tumor microenvironment with precise photothermal therapy by calreticulin nanobody-engineered probiotics., PMID:39303415
Photodynamic Therapy Using RGD-Functionalized Quantum Dots Elicit a Potent Immune Response in a Syngeneic Mouse Model of Pancreatic Cancer., PMID:39290860
Synthesis and immunotherapy efficacy of a PD-L1 small-molecule inhibitor combined with its 131I-iodide labelled isostructural compound., PMID:39276489
Selective targeting of mutated calreticulin by the monoclonal antibody INCA033989 inhibits oncogenic function of MPN., PMID:39255409
A Case of Autoimmune Myelofibrosis Associated With Autoimmune Hepatitis., PMID:39247061
The CALR mutations enhance the expression of the immunosuppressive proteins GARP and LAP on peripheral blood lymphocytes through increased binding of activated platelets., PMID:39161981
Blockade of glucose-6-phosphate dehydrogenase induces immunogenic cell death and accelerates immunotherapy., PMID:39089738
Sequential Double Immunoblotting with Peptide Antibodies., PMID:38997494
Synergistic action of gemcitabine and celecoxib in promoting the antitumor efficacy of anti-programmed death-1 monoclonal antibody by triggering immunogenic cell death., PMID:38988937
Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response., PMID:38950333
Detection of anti-calreticulin antibody in the sera of Chinese patients with primary Sjögren syndrome., PMID:38896912
Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment., PMID:38885318
Branched glycopolymer prodrug-derived nanoassembly combined with a STING agonist activates an immuno-supportive status to boost anti-PD-L1 antibody therapy., PMID:38799622
Dual role of the peptide-loading complex as proofreader and limiter of MHC-I presentation., PMID:38771881
Characterization of antigenic proteins of the Taenia solium postoncospheral form., PMID:38705360
Crystal structure of Trichinella spiralis calreticulin and the structural basis of its complement evasion mechanism involving C1q., PMID:38690267
Codelivery of anti-CD47 antibody and chlorin e6 using a dual pH-sensitive nanodrug for photodynamic immunotherapy of osteosarcoma., PMID:38560565
CD40 stimulation via CD40 ligand enhances adenovirus-mediated tumour immunogenicity including 'find-me', 'eat-me', and 'kill-me' signalling., PMID:38494863
Optical biosensor based on weak measurement for ultra-sensitive detection of calreticulin in human serum., PMID:38404297
The combination of calreticulin-targeting L-ASNase and anti-PD-L1 antibody modulates the tumor immune microenvironment to synergistically enhance the antitumor efficacy of radiotherapy., PMID:38323311
Targeting TACC3 Induces Immunogenic Cell Death and Enhances T-DM1 Response in HER2-Positive Breast Cancer., PMID:38319231
Opaganib (ABC294640) Induces Immunogenic Tumor Cell Death and Enhances Checkpoint Antibody Therapy., PMID:38069222
Therapeutic Efficacy of Oxaliplatin and Pembrolizumab Combination Treatment for Triple-Negative Breast Cancer., PMID:38007758
Quantitative image analysis of intracellular protein translocation in 3-dimensional tissues for pharmacodynamic studies of immunogenic cell death., PMID:37981052
AMPK activation induces immunogenic cell death in AML., PMID:37903311
Hollow Cu2MoS4 nanoparticles loaded with immune checkpoint inhibitors reshape the tumor microenvironment to enhance immunotherapy for pancreatic cancer., PMID:37890815
A single photodynamic priming protocol augments delivery of ⍺-PD-L1 mAbs and induces immunogenic cell death in head and neck tumors., PMID:37818742
Recent advances in therapies for primary myelofibrosis., PMID:37771602
Reviving immunogenic cell death upon targeting TACC3 enhances T-DM1 response in HER2-positive breast cancer., PMID:37745348
For research use only. Not for human or drug use.
