Catalog No.
RHN83501
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, WB: 1:500-1:1000
Target
DOCK8, Dedicator of cytokinesis protein 8
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q8NF50
Applications
IF, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2S40
Hyper IgE Syndrome: Bridging the Gap Between Immunodeficiency, Atopy, and Allergic Diseases., PMID:40082265
Case report: Advanced age at transplantation and pre-emptive treatment with dupilumab in DOCK8 deficiency., PMID:39936153
DOCK8 gene mutation alters cell subsets, BCR signaling, and cell metabolism in B cells., PMID:39616183
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing., PMID:39381601
Reconstitution of Norovirus-Specific T-Cell Responses Following Hematopoietic Stem Cell Transplantation in Patients With Inborn Errors of Immunity and Chronic Norovirus Infection., PMID:39140311
Successfully treated with siltuximab and prednisone in a 7-year-old girl with DOCK8-deficiency presenting as recurrent wart-like lesions: a case report., PMID:39044832
Siglec-6 as a therapeutic target for cell migration and adhesion in chronic lymphocytic leukemia., PMID:38890323
[Experimental study of APB-DOCK8 transgenic tomato vaccine for caries prevention]., PMID:38494961
Analysis and Regulatory Mechanisms of Platelet-Related Genes in Patients with Ischemic Stroke., PMID:38175286
Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8., PMID:38159726
Genetic Characterization of Primary Mediastinal B-Cell Lymphoma: Pathogenesis and Patient Outcomes., PMID:38055913
A systematic review regarding the prevalence of malignancy in patients with the hyper-IgE syndrome., PMID:37924455
Hyper IgE Syndromes., PMID:37702167
Efficacy of Dupilumab in Treating Atopic Dermatitis With Recurrent Eczema Herpeticum in a Patient With DOCK8-Deficiency Hyper-IgE Syndrome: A Case Report., PMID:37701007
IL-17A inhibitor-induced leucocytoclastic vasculitis is responsive to IL-23 blockade in a psoriatic arthritis patient., PMID:37679036
MYD88L265P augments proximal B-cell receptor signaling in large B-cell lymphomas via an interaction with DOCK8., PMID:37467575
LRP2 and DOCK8 Are Potential Antigens for mRNA Vaccine Development in Immunologically 'Cold' KIRC Tumours., PMID:36851274
The Autoimmune Manifestations in Patients with Genetic Defects in the B Cell Development and Differentiation Stages., PMID:36790564
Multi-Omics Profiling in PGM3 and STAT3 Deficiencies: A Tale of Two Patients., PMID:36768728
Autoimmune myositis and autoimmune hemolytic anemia in two sisters with DOCK8-deficient hyper-IgE syndrome., PMID:36633785
Severe Protein Loss in a 6-month-old Exclusively Breastfed Infant with Atopic Dermatitis., PMID:36254543
When to suspect inborn errors of immunity in Epstein-Barr virus-related lymphoproliferative disorders., PMID:36209991
Confirmation of Hyperimmunoglobulin E Syndrome in Two Patients with an Ocular Problem: Detection of Two New DOCK8 Mutations., PMID:35822685
Proteomics Profiling to Distinguish DOCK8 Deficiency From Atopic Dermatitis., PMID:35386989
Dedicator of cytokinesis 8 deficiency and hyperimmunoglobulin E syndrome: A case report., PMID:35119052
DOCK8-expressing T follicular helper cells newly generated beyond self-organized criticality cause systemic lupus erythematosus., PMID:34977502
Investigating the Variation of TREC/KREC in Combined Immunodeficiencies., PMID:34418894
Genetic Analysis of a Cohort of 275 Patients with Hyper-IgE Syndromes and/or Chronic Mucocutaneous Candidiasis., PMID:34390440
Common Variable Immunodeficiency and Other Immunodeficiency Syndromes in Bronchiectasis., PMID:34261177
Lineage-Specific Chimerism and Outcome After Hematopoietic Stem Cell Transplantation for DOCK8 Deficiency., PMID:34080085
Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations., PMID:34051223
CCL2 regulation of MST1-mTOR-STAT1 signaling axis controls BCR signaling and B-cell differentiation., PMID:33879857
Hematopoietic stem cell transplantation in an infant with dedicator of cytokinesis 8 (DOCK8) deficiency associated with systemic lupus erythematosus: A case report., PMID:33787566
Clinical Profile of Hyper-IgE Syndrome in India., PMID:33717144
Daratumumab for delayed RBC engraftment following major ABO mismatched haploidentical bone marrow transplantation., PMID:33528026
Hemolysis inhibits humoral B-cell responses and modulates alloimmunization risk in patients with sickle cell disease., PMID:33152749
STAT3 couples with 14-3-3σ to regulate BCR signaling, B-cell differentiation, and IgE production., PMID:33045280
The Child with Elevated IgE and Infection Susceptibility., PMID:32830295
A Novel Pathogenic Variant in CARMIL2 (RLTPR) Causing CARMIL2 Deficiency and EBV-Associated Smooth Muscle Tumors., PMID:32625199
DOCK8 is essential for LFA-1-dependent positioning of T follicular helper cells in germinal centers., PMID:32573493
Biological and clinical significance of T helper 17 cell deficiency: insight into monogenic defects., PMID:32549544
Improving the diagnostic efficiency of primary immunodeficiencies with targeted next-generation sequencing., PMID:32531373
New Gene Variants Associated with the Risk of Chronic HBV Infection., PMID:32297155
Refractory and Fatal Presentation of Severe Autoimmune Hemolytic Anemia in a Child With the DNASE1L3 Mutation Complicated With an Additional DOCK8 Variant., PMID:32205782
Omalizumab in the Treatment of Hyper-IgE Syndrome: 2 Case Reports., PMID:31820738
Identification of a T follicular helper cell subset that drives anaphylactic IgE., PMID:31371561
DOCK8 mutation diagnosed using whole-exome sequencing of the dried blood spot-derived DNA: a case report of an Iraqi girl diagnosed in Japan., PMID:31242861
A Rare Case of Hyper IgE Syndrome with Vocal Cords Involvement., PMID:31066259
Hematopoietic stem cell transplant effectively rescues lymphocyte differentiation and function in DOCK8-deficient patients., PMID:31021819
The first cohort of Iranian patients with hyper immunoglobulin E syndrome: A long-term follow-up and genetic analysis., PMID:30801830
For research use only. Not for human or drug use.
