Catalog No.
YHD07501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gly403
Predicted molecular weight
47.64 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P14902
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
INDO, IDO1, Indoleamine-pyrrole 2,3-dioxygenase, Indoleamine 2,3-dioxygenase 1, IDO-1, IDO
Indoleamine 2,3-dioxygenase-1 expression in non-small-cell lung cancer: analyses of prevalence, clinical correlations and prognostic impact in 2 large patient cohorts., PMID:40475772
Phospholipase A2 group IIA activates Indoleamine 2,3-dioxygenase 1 to drive the progression of pulmonary fibrosis., PMID:40473047
Targeted inhibition of IDO1 by Kushenol A enhances radiosensitivity in non-small cell lung cancer., PMID:40466860
The role of immune checkpoint molecules in PRRSV-2-induced immune modulation: insights from comparative in vivo evaluation including NADC34-like PRRSV., PMID:40459260
A Biodegradable 2D Metallic MoS2 Genesheet for Synergistic NIR-II Photothermal Immunotherapy., PMID:40457643
The AhR regulates IFN-induced immune checkpoints in lung cancer cells through HNRNPH1, an RNA-binding protein, and INCR1, a novel long non-coding RNA., PMID:40449595
Neovascular pruning by IDO1 inhibitors can potentiate immunogenic cytotoxicity of ischemia-targeted agents to synergistically enhance anti-PD-1 responsiveness., PMID:40447318
IDO1 improves postischemic neovascularization in aged mice by boosting endothelial NAD+ de novo synthesis and curbing endothelial senescence., PMID:40440793
Primordial follicle activation related genes screening and differential expressed analysis by transcriptome sequencing in buffalo ovary after PI3K and mTOR stimulators activated., PMID:40434902
Splenic comparative transcriptome analysis reveals the immunological mode of undomesticated Gayal (Bos frontalis) for adapting to harsh environments., PMID:40394466
Equol neutralizes toxin B to combat Clostridioides difficile infection without disrupting the gut microbiota., PMID:40378594
Single-cell sequencing and spatial transcriptomics reveal FAS+ T cell and autophagy-related signatures predicting chemoimmunotherapy response in diffuse large B-cell lymphoma patients., PMID:40374987
Phosphorylation of ITIM motifs drives the structural transition of indoleamine 2,3-dioxygenase 1 between enzymatic and non-enzymatic states., PMID:40371730
IL-32-producing CD8+ memory T cells define immunoregulatory niches in human cutaneous leishmaniasis., PMID:40371647
Remodeling tumor immunosuppressive microenvironment through dual activation of immunogenic panoptosis and ferroptosis by H2S-amplified nanoformulation to enhance cancer immunotherapy., PMID:40370544
IDO can improve ovarian function in premature ovarian insufficiency via AhR and regulatory T cells., PMID:40358004
[Banxia Xiexin Decoction reshapes tryptophan metabolism to inhibit progression of colon cancer]., PMID:40350914
Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK., PMID:40348014
Immunohistochemical Profiling of IDO1 and IL4I1 in Head and Neck Squamous Cell Carcinoma: Interplay for Metabolic Reprogramming?, PMID:40332319
1, 8-Cineole Ameliorated Staphylococcus aureus-Induced Pneumonia through Modulation of TRP-KYN and Arginine-NO Reprogramming., PMID:40314286
HDLR-SR-BI Expression and Cholesterol Uptake are Regulated via Indoleamine-2,3-dioxygenase 1 in Macrophages under Inflammation., PMID:40309829
A novel method for isolation of tumor infiltrating myeloid-derived suppressor cells from human lung tumor tissue., PMID:40307421
Edaravone protects against cuprizone-induced demyelination in rats by modulating TNF-α/NF-ĸB/NLRP3 signaling and the kynurenine pathway., PMID:40294777
[Investigation of Indoleamine 2,3-Dioxygenase Enzyme in SARS-CoV-2 Infection According to Disease Severity]., PMID:40277265
L-Kynurenine regulates immune response in ICIs-associated myocarditis via JAK/STAT pathway., PMID:40267722
IDO1 inhibitors block septic cytokine storm by suppressing the IDO1-AHR-CYP1A1 axis., PMID:40245547
Indoleamine 2,3-dioxygenase 1 alters the proportions of B cell subpopulations in the microenvironment of acute myeloid leukemia., PMID:40234305
Comprehensive analysis of metabolism-related gene biomarkers reveals their impact on the diagnosis and prognosis of triple-negative breast cancer., PMID:40217479
Proof of concept study for developing 1-thienyl-β-carboline derivatives as IDO1 and TDO dual inhibitors to treat Parkinson's disease complicating depression., PMID:40215562
Evaluating the role of kynurenine/tryptophan ratio as an indicator of disease activity in Indian patients with inflammatory bowel disease. A case-control study., PMID:40214291
[Immune Checkpoints Mediate Tumor Immune Regulation
through Metabolic Pathways]., PMID:40210481
Lactobacillus Johnsonii YH1136 alleviates schizophrenia-like behavior in mice: a gut-microbiota-brain axis hypothesis study., PMID:40175911
L-Kynurenine activates the AHR-PCSK9 pathway to mediate the lipid metabolic and ovarian dysfunction in polycystic ovary syndrome., PMID:40169085
IDO1-mediated AhR activation up-regulates pentose phosphate pathway via NRF2 to inhibit ferroptosis in lung cancer., PMID:40164341
Chronic social stress induces generalized hyper-sensitivity to aversion: A mouse model with translational validity for understanding and treating negative valence disorders., PMID:40154946
Inflammatory Markers in the Blood of Spastic Cerebral Palsy Children: A Case-Control Study., PMID:40150625
Therapeutic targeting of the Tryptophan-Kynurenine Axis for HTR-8/SVneo trophoblast proliferation and migration in unexplained recurrent spontaneous abortion†., PMID:40143408
Drug repurposing through Biophysical Insights: Focus on Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase Dual Inhibitors., PMID:40133710
CHI3L1: a key driver in gastritis-to-cancer transformation., PMID:40108688
The Kynurenine Pathway and Indole Pathway in Tryptophan Metabolism Influence Tumor Progression., PMID:40103267
Epacadostat Overcomes Cetuximab Resistance in Colorectal Cancer by Targeting IDO-Mediated Tryptophan Metabolism., PMID:40103010
IDO Believe in Immunotherapy., PMID:40100365
Myeloid-derived suppressor cell inhibits T-cell-based defense against Klebsiella pneumoniae infection via IDO1 production., PMID:40096073
Integrated Analysis of Ferroptosis and Immune Infiltration in Ulcerative Colitis Based on Bioinformatics., PMID:40093944
Ethyl acetate extract from Herpetospermun cardigerum wall. Ameliorated concanavalin A-induced autoimmune hepatitis in mice by reprofiling gut microenvironment to modulate IDO1/KYN and PI3K/AKT/NF-κB pathways., PMID:40081510
Radiation-Enhanced AF1q Moves Center Stage as a Key Driver to Favorable Tumor Stage in Rectal Cancer Patients., PMID:40062505
IDO1 inhibition enhances CLDN18.2-CAR-T cell therapy in gastrointestinal cancers by overcoming kynurenine-mediated metabolic suppression in the tumor microenvironment., PMID:40045363
Discovery and Optimization of Novel Apo-IDO1 Inhibitors by a Pharmacophore-Based Structural Simplification Strategy., PMID:40042617
Indoleamine 2,3-dioxygenase 1 drives epithelial cells ferroptosis in influenza-induced acute lung injury., PMID:40023977
Therapeutic effect of long-interval repeated subcutaneous administration of canine amniotic membrane-derived mesenchymal stem cells in atopic dermatitis mouse model., PMID:40011929
For research use only. Not for human or drug use.
