Overview
Catalog No.
RHN80101
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Target
2'(3')-polynucleotidase, Bifunctional polynucleotide phosphatase/kinase, PNKP, Polynucleotide kinase-3'-phosphatase, DNA 5'-kinase/3'-phosphatase
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q96T60
Applications
IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2R95
Data Image
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Immunohistochemistry analysis of paraffin-embedded Human breast cancer using PNK/PNKP antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
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Western blot analysis of PNK/PNKP in Hela, A549, HL-60, U251 lysates using PNKP antibody.
References
Site-specific acetylation of polynucleotide kinase 3'-phosphatase regulates its distinct role in DNA repair pathways., PMID:38224455
Site-specific acetylation of polynucleotide kinase 3'-phosphatase (PNKP) regulates its distinct role in DNA repair pathways., PMID:37645927
PNKP is required for maintaining the integrity of progenitor cell populations in adult mice., PMID:34226276
Genetic assessment and folate receptor autoantibodies in infantile-onset cerebral folate deficiency (CFD) syndrome., PMID:29661558
The human polynucleotide kinase/phosphatase (hPNKP) inhibitor A12B4C3 radiosensitizes human myeloid leukemia cells to Auger electron-emitting anti-CD123 ¹¹¹In-NLS-7G3 radioimmunoconjugates., PMID:24637100
A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor., PMID:18388863
Datasheet
For research use only. Not for human or drug use.
