Catalog No.
RHN75301
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, WB: 1:1000-1:2000
Target
pp62, Docking protein 1, p62(dok), Downstream of tyrosine kinase 1, DOK1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q99704
Applications
IF, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2R24
Overexpression of FcγRIIB regulates downstream protein phosphorylation and suppresses B cell activation to ameliorate systemic lupus erythematosus., PMID:32945349
Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion., PMID:31638742
Phosphoproteomics Analysis Identifies Novel Candidate Substrates of the Nonreceptor Tyrosine Kinase, Src-related Kinase Lacking C-terminal Regulatory Tyrosine and N-terminal Myristoylation Sites (SRMS)., PMID:29496907
Anti-inflammation conferred by stimulation of CD200R1 via Dok1 pathway in rat microglia after germinal matrix hemorrhage., PMID:28792282
Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy., PMID:22078222
The leukocyte receptor CD84 inhibits Fc epsilon RI-mediated signaling through homophilic interaction in transfected RBL-2H3 cells., PMID:18243321
A human CD4 monoclonal antibody for the treatment of T-cell lymphoma combines inhibition of T-cell signaling by a dual mechanism with potent Fc-dependent effector activity., PMID:17942927
Dok-1 is a positive regulator of IL-4 signalling and IgE response., PMID:17827176
Dok-3 plays a nonredundant role in negative regulation of B-cell activation., PMID:17363732
Dok-1 and Dok-2 are negative regulators of T cell receptor signaling., PMID:17329234
A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter., PMID:16941570
High-level expression of Dok-1 in neurons of the primate prefrontal cortex and hippocampus., PMID:14705142
A spectrum of mutations in SH2D1A that causes X-linked lymphoproliferative disease and other Epstein-Barr virus-associated illnesses., PMID:12152986
Clustering the mast cell function-associated antigen (MAFA) leads to tyrosine phosphorylation of p62Dok and SHIP and affects RBL-2H3 cell cycle., PMID:12008030
Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product., PMID:11477403
The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells., PMID:10755621
Bilevel control of B-cell activation by the inositol 5-phosphatase SHIP., PMID:11043768
Mediation by the protein-tyrosine kinase Tec of signaling between the B cell antigen receptor and Dok-1., PMID:10823839
Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling., PMID:10640270
Sam68 is a Ras-GAP-associated protein in mitosis., PMID:9571195
Differential effects of B cell receptor and B cell receptor-FcgammaRIIB1 engagement on docking of Csk to GTPase-activating protein (GAP)-associated p62., PMID:9221755
Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok., PMID:9008161
The human p62 cDNA encodes Sam68 and not the RasGAP-associated p62 protein., PMID:8548822
Purification and cDNA sequence of a murine protein homologous to the human p62 tyrosine phosphoprotein that associates with the Ras GTPase-activating protein p120 GAP., PMID:7541765
Insulin-like growth factor-1 stimulation of cells induces formation of complexes containing phosphatidylinositol-3-kinase, guanosine triphosphatase-activating protein (GAP), and p62 GAP-associated protein., PMID:7828547
Serum-induced signal transduction determines the peripheral location of beta-actin mRNA within the cell., PMID:8063859
Functional evidence for an extracellular calcium receptor mechanism triggering tyrosine kinase activation associated with mouse keratinocyte differentiation., PMID:8063817
Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor, p62, and GTPase-activating protein., PMID:8175658
Fc gamma RII cross-linking inhibits anti-Ig-induced erg-1 and erg-2 expression in BCL1., PMID:8133028
Targets of B lymphocyte antigen receptor signal transduction include the p21ras GTPase-activating protein (GAP) and two GAP-associated proteins., PMID:8419471
For research use only. Not for human or drug use.
