Catalog No.
RHN62002
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Target
Inhibitor of nuclear factor kappa-B kinase subunit gamma, NEMO, IKKAP1, IKK-gamma, IkB kinase-associated protein 1, IkB kinase subunit gamma, FIP-3, NF-kappa-B essential modifier, NF-kappa-B essential modulator, IKBKG, I-kappa-B kinase subunit gamma, FIP3, IKKG
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9Y6K9
Applications
FCM, IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2P25
Identification of soluble biomarkers that associate with distinct manifestations of long COVID., PMID:40307449
NF-ΚB Activation as a Key Driver in Chronic Lymphocytic Leukemia Evolution to Richter's Syndrome: Unraveling the Influence of Immune Microenvironment Dynamics., PMID:39596634
Finding NEMO in the thymus., PMID:39432904
Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseases., PMID:39352576
Role of Skewed X-Chromosome Inactivation in Common Variable Immunodeficiency., PMID:38265673
Genome-wide association studies for immunoglobulin concentrations in colostrum and serum in Chinese Holstein., PMID:35012443
NeMO mutations: a rare cause of monogenic Behçet-like disease., PMID:32954429
Improving the diagnostic efficiency of primary immunodeficiencies with targeted next-generation sequencing., PMID:32531373
Successful Allogeneic Stem Cell Transplantation in Nuclear Factor-Kappa B Essential Modulator Deficiency Syndrome After Treosulfan-Based Conditioning: A Case Report., PMID:32035679
T Cell Impairment Is Predictive for a Severe Clinical Course in NEMO Deficiency., PMID:31965418
Infliximab therapy for inflammatory colitis in an infant with NEMO deficiency., PMID:31713830
Viral antigens elicit augmented immune responses in primary Sjögren's syndrome., PMID:31665501
Placental Expression of NEMO Protein in Normal Pregnancy and Preeclampsia., PMID:30723530
Cell-Permeable Bicyclic Peptidyl Inhibitors against NEMO-IκB Kinase Interaction Directly from a Combinatorial Library., PMID:30176143
Intravitreal injection of ranibizumab in severe retinopathy of incontinentia pigmenti., PMID:29630932
Functional Evaluation of an IKBKG Variant Suspected to Cause Immunodeficiency Without Ectodermal Dysplasia., PMID:28993958
The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling., PMID:26525107
Immunodeficiency among children with recurrent invasive pneumococcal disease., PMID:25831419
Immunoblot analysis of linear polyubiquitination of NEMO., PMID:25736756
BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response., PMID:24732096
Diagnosis and treatment in anhidrotic ectodermal dysplasia with immunodeficiency., PMID:22635013
Successful treatment with infliximab for inflammatory colitis in a patient with X-linked anhidrotic ectodermal dysplasia with immunodeficiency., PMID:21993693
Disseminated BCG infection mimicking metastatic nasopharyngeal carcinoma in an immunodeficient child with a novel hypomorphic NEMO mutation., PMID:21755389
Congenital alterations of NEMO glutamic acid 223 result in hypohidrotic ectodermal dysplasia and immunodeficiency with normal serum IgG levels., PMID:21704885
Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome., PMID:20959607
A custom 148 gene-based resequencing chip and the SNP explorer software: new tools to study antibody deficiency., PMID:20652909
A novel missense mutation in the nuclear factor-κB essential modulator (NEMO) gene resulting in impaired activation of the NF-κB pathway and a unique clinical phenotype presenting as MRSA subdural empyema., PMID:20652730
Allogeneic hematopoietic stem cell transplantation for X-linked ectodermal dysplasia and immunodeficiency: case report and review of outcomes., PMID:19225723
ATM mediates constitutive NF-kappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia., PMID:19079347
IKBKG (nuclear factor-kappa B essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function., PMID:18179816
Induction of human monocyte interleukin (IL)-8 by fibrinogen through the toll-like receptor pathway., PMID:17624583
IRAK4 and NEMO mutations in otherwise healthy children with recurrent invasive pneumococcal disease., PMID:16950813
Transient hemophagocytosis with deficient cellular cytotoxicity, monoclonal immunoglobulin M gammopathy, increased T-cell numbers, and hypomorphic NEMO mutation., PMID:16636116
Novel splicing mutation in the NEMO (IKK-gamma) gene with severe immunodeficiency and heterogeneity of X-chromosome inactivation., PMID:16333836
Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation., PMID:15578091
Nuclear factor kappaB essential modulator-deficient child with immunodeficiency yet without anhidrotic ectodermal dysplasia., PMID:15577852
For research use only. Not for human or drug use.
