Anti-HLA-DMB Antibody (R2N42)

Catalog No.

RHM02201

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

FCM: 1:20-1:100, WB: 1:1000-1:2000

Target

HLA-DMB, RING7, DMB, Really interesting new gene 7 protein, HLA class II histocompatibility antigen, DM beta chain, MHC class II antigen DMB

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P28068

Applications

FCM, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.

Clone ID

R2N42

Analysis of B Cell Receptor-Mediated Antigen Extraction by B Lymphocytes from Plasma Membrane Sheets Using Confocal Microscopy., PMID:34028716

A Missing Switch in Peptide Exchange for MHC Class II Molecules., PMID:31708929

What to do with HLA-DO/H-2O two decades later?, PMID:30683973

Heterodimer HLA-DM Fused with Constant Fragment of the Heavy Chain of the Human Immunoglobulin Accelerates Influenza Hemagglutinin HA306-318 Loading to HLA-DR1., PMID:27265131

The MHC class II cofactor HLA-DM interacts with Ig in B cells., PMID:25098292

Susceptibility to HLA-DM protein is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide., PMID:25002586

A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC(50) determination., PMID:24583195

Immunodeficiency and autoimmunity in H2-O-deficient mice., PMID:23209323

DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms., PMID:20408893

Increased HLA-DMB expression in the tumor epithelium is associated with increased CTL infiltration and improved prognosis in advanced-stage serous ovarian cancer., PMID:19047092

Evidence for a human leucocyte antigen-DM-induced structural change in human leucocyte antigen-DObeta., PMID:19019088

An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice., PMID:18209058

A point mutation in the groove of HLA-DO allows egress from the endoplasmic reticulum independent of HLA-DM., PMID:15849268

Constitutive intracellular expression of human leukocyte antigen (HLA)-DO and HLA-DR but not HLA-DM in trophoblast cells., PMID:15620461

Association of HLA-DM polymorphism with the production of antiphospholipid antibodies., PMID:15547089

Differential up-regulation of HLA-DM, invariant chain, and CD83 on myeloid and plasmacytoid dendritic cells from peripheral blood., PMID:14705986

Modulation of antigen presentation by autoreactive B cell clones specific for GAD65 from a type I diabetic patient., PMID:14678267

Lack of association between transporter associated with antigen processing (TAP) and HLA-DM gene polymorphisms and antibody levels following measles vaccination., PMID:12786997

Human germinal center B cells differ from naive and memory B cells by their aggregated MHC class II-rich compartments lacking HLA-DO., PMID:12663675

Binding interactions between peptides and proteins of the class II major histocompatibility complex., PMID:11857638

HLA-DM, HLA-DO and tapasin: functional similarities and differences., PMID:11790529

Role of tapasin in MHC class I antigen presentation in vivo., PMID:11774611

All peptide-MHC complexes are not created equal., PMID:11753403

Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes., PMID:11743588

The impact of H2-DM on humoral immune responses., PMID:11714799

Accessory proteins that control the assembly of MHC molecules with peptides., PMID:11444385

Conformational alterations during biosynthesis of HLA-DR3 molecules controlled by invariant chain and HLA-DM., PMID:11298327

Unusual expression of human lymphocyte antigen class II in normal renal microvascular endothelium., PMID:11168931

H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection., PMID:10880524

Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO., PMID:10748231

Unexpected reactivities of T cells selected by a single MHC-peptide ligand., PMID:10490950

HLA-DM and invariant chain are expressed by thyroid follicular cells, enabling the expression of compact DR molecules., PMID:10069425

HLA-DM is expressed on the cell surface and colocalizes with HLA-DR and invariant chain in human Langerhans cells., PMID:9879837

Chemical chaperones enhance superantigen and conventional antigen presentation by HLA-DM-deficient as well as HLA-DM-sufficient antigen-presenting cells and enhance IgG2a production in vivo., PMID:9759841

Binding affinity independent contribution of peptide length to the stability of peptide-HLA-DR complexes in live antigen presenting cells., PMID:9712349

Intracellular formation and cell surface expression of a complex of an intact lysosomal protein and MHC class II molecules., PMID:9637490

Modulation of peptide-dependent allospecific epitopes on HLA-DR4 molecules by HLA-DM., PMID:9536430

Altered antigen presentation in mice lacking H2-O., PMID:9492004

Polymorphisms of DMA and DMB genes in Japanese systemic lupus erythematosus., PMID:9487257

Novel mutants define genes required for the expression of human histocompatibility leukocyte antigen DM: evidence for loci on human chromosome 6p., PMID:9348304

Major histocompatibility complex class II compartments in human and mouse B lymphoblasts represent conventional endocytic compartments., PMID:9348281

Assembly of an abundant endogenous major histocompatibility complex class II/peptide complex in class II compartments., PMID:9079799

HLA-DMA and DMB genotyping in patients with rheumatoid arthritis., PMID:9058646

Association of DM genes in systemic sclerosis is secondary to the association with HLA genes., PMID:9225871

HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport., PMID:8890155

Targeting signal and subcellular compartments involved in the intracellular trafficking of HLA-DMB., PMID:8757605

HLA-DM is localized to conventional and unconventional MHC class II-containing endocytic compartments., PMID:8624813

HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading., PMID:7606781

The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent., PMID:7807005

Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells., PMID:7600288

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