Research Grade Vopratelimab

Catalog No.

DHJ92101

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

CD278, ICOS, Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, AILIM

Concentration

0.93mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9Y6W8

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

JTX-2011, CAS: 2039148-04-2

Clone ID

Vopratelimab

ICOS agonist vopratelimab modulates follicular helper T cells and improves B cell function in common variable immunodeficiency., PMID:38621471

Analysis and Regulatory Mechanisms of Platelet-Related Genes in Patients with Ischemic Stroke., PMID:38175286

Agonizing over the Stimulatory Immune Checkpoint ICOS., PMID:35792807

First-in-Human Phase I/II ICONIC Trial of the ICOS Agonist Vopratelimab Alone and with Nivolumab: ICOS-High CD4 T-Cell Populations and Predictors of Response., PMID:35511938

ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models., PMID:32970735

Document Download

Research Grade Vopratelimab.pdf