Catalog No.
RHK66402
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IF: 1:50-1:200, WB: 1:1000-1:2000
Target
Mitotic centromere-associated kinesin, Kinesin-like protein 6, KIF2C, Kinesin-like protein KIF2C, KNSL6, MCAK
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q99661
Applications
FCM, IF, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2M74
Polo-like kinase 1 regulates the stability of the mitotic centromere-associated kinesin in mitosis., PMID:24931513
Control of MCAK degradation and removal from centromeres., PMID:22422706
Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis., PMID:20705812
MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes., PMID:20406800
Functional and spatial regulation of mitotic centromere-associated kinesin by cyclin-dependent kinase 1., PMID:20368358
NY-CO-58/KIF2C is overexpressed in a variety of solid tumors and induces frequent T cell responses in patients with colorectal cancer., PMID:19937794
Interplay of microtubule dynamics and sliding during bipolar spindle formation in mammalian cells., PMID:19931454
Kinetochore microtubule dynamics and attachment stability are regulated by Hec1., PMID:17129782
Deciphering protein function during mitosis in PtK cells using RNAi., PMID:16796742
The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK., PMID:15302853
Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity., PMID:14972678
Aurora B regulates MCAK at the mitotic centromere., PMID:14960279
Localization of motor-related proteins and associated complexes to active, but not inactive, centromeres., PMID:9499420
For research use only. Not for human or drug use.
