Catalog No.
YHC98801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn35-Leu315
Predicted molecular weight
33.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P13612
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ITGA4, CD49d, CD49 antigen-like family member D, CD49D, VLA-4 subunit alpha, Integrin alpha-IV, Integrin alpha-4
Myelin Formation by Oligodendrocytes Is Enhanced Through Laminin-411 and Its Derived Peptide., PMID:40342064
Merocytophagy is an integrin-stabilized macrophage response to microbes reliant on Syk signaling., PMID:40313956
A proteogenomic tool uncovers protein markers for human microglial states., PMID:40236015
Longitudinal CNS and systemic T-lymphocyte and monocyte activation before and after antiretroviral therapy beginning in primary HIV infection., PMID:40070827
Evaluation of Constitutive or Induced Activation State of the VLA-4 Integrin in Human and Murine Samples., PMID:40029514
B-Cell and T-Cell Populations in Peripheral Blood Linked to Ocrelizumab Treatment Efficacy in Multiple Sclerosis., PMID:40010950
Role of Siglec-E in MC903-Induced Atopic Dermatitis., PMID:39967561
In vitro studies of human erythropoiesis using a 3D silk-based bone marrow model that generates erythroblastic islands., PMID:39951616
Integrin beta 1 and fibronectin mediate extracellular vesicle uptake and functional RNA delivery., PMID:39947471
Differentiation of human hyalocytes from induced pluripotent stem cells through ascorbic acid treatment., PMID:39937308
Evaluation of VLA-4 (Integrin α4β1) as a Shared Target for Radiopharmaceutical Therapy across Solid Tumors., PMID:39911068
CD22 modulation alleviates amyloid β-induced neuroinflammation., PMID:39910617
A Phenotypically Distinct Human Th2 Cell Subpopulation Is Associated With Development of Allergic Disorders in Infancy., PMID:39899007
Fatty acid binding protein 3 activates endothelial adhesion of circulating monocytes and impairs endothelial angiogenesis., PMID:39894951
Triple knockdown of CD11a, CD49d, and PSGL1 in T cells reduces CAR-T cell toxicity but preserves activity against solid tumors in mice., PMID:39841806
Anti-PD1-/PDL1-induced chronic intestinal pseudo-obstruction: three cases treated with vedolizumab after corticosteroid failure with mixed results., PMID:39751892
Cell therapy with human IL-10-producing ILC2s limits xenogeneic graft-versus-host disease by inhibiting pathogenic T cell responses., PMID:39721022
Efficient gene deletion of Integrin alpha 4 in primary mouse CD4 T cells using CRISPR RNA pair-mediated fragmentation., PMID:39720725
Molecular Profiling Identifies CD49d and CD79b as Predictive Markers for Acquired Acalabrutinib Resistance in Patients With Chronic Lymphocytic Leukemia., PMID:39716442
Alpha-Synuclein Inhibition Promotes Erythropoiesis by Affecting Methylation Modifications of Fructose and Mannose Metabolism., PMID:39704132
Neutrophils in the Spotlight-An Analysis of Neutrophil Function and Phenotype in ARDS., PMID:39684262
Sportizumab - Multimodal progressive exercise over 10 weeks decreases Th17 frequency and CD49d expression on CD8+ T cells in relapsing-remitting multiple sclerosis: A randomized controlled trial., PMID:39675643
Differentiating erythroblasts adapt to mechanical stimulation by upregulation of cholesterol biosynthesis via S1P/SREBP-induced HMGCR expression., PMID:39627481
The TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding., PMID:39609640
Carnosic acid inhibits integrin expression and prevents pulmonary metastasis of melanoma., PMID:39577858
Cell surface marker heterogeneity in human myeloma cell lines for modeling of disease and therapy., PMID:39567630
Anti-CD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8+ T-cell cytotoxicity after traumatic brain injury., PMID:39427160
Pharmacokinetics and Pharmacodynamics of Natalizumab 6-Week Dosing vs Continued 4-Week Dosing for Relapsing-Remitting Multiple Sclerosis., PMID:39393045
Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens., PMID:39373475
A novel whole blood assay to quantify the release of T cell associated cytokines in response to Bordetella pertussis antigens., PMID:39353482
The significance of CD49f expression in pediatric B-cell acute lymphoblastic leukemia., PMID:39259664
The heart is a resident tissue for hematopoietic stem and progenitor cells in zebrafish., PMID:39217144
Dual nature of type I interferon responses and feedback regulations by SOCS1 dictate malaria mortality., PMID:39181199
[Old and New Biologics and Small Molecules in Inflammatory Bowel Disease: Anti Integrins]., PMID:39176460
The VLA-4 integrin is constitutively active in circulating chronic lymphocytic leukemia cells via BCR autonomous signaling: a novel anchor-independent mechanism exploiting soluble blood-borne ligands., PMID:39143370
Tagetes erecta L.: A traditional medicine effective in inflammatory process treatment., PMID:38996948
miR-200c-3p regulates α4 integrin-mediated T cell adhesion and migration., PMID:38936759
A novel surface marker CD49d promotes TNF expression in oyster agranulocytes by mediating the MAPK pathway., PMID:38897309
The protective roles of integrin α4β7 and Amphiregulin-expressing innate lymphoid cells in lupus nephritis., PMID:38806623
Long-lasting severe anemia following treatment with natalizumab for relapsing-remitting multiple sclerosis: a case report., PMID:38736000
PB006: A Natalizumab Biosimilar., PMID:38683493
Comprehensive overview of novel chemical drugs for ulcerative colitis: focusing on phase 3 and beyond., PMID:38591242
Differentiation marker-negative CD4+ T cells persist after yellow fever virus vaccination and contribute to durable memory., PMID:38559113
BV2 Membrane-Coated PEGylated-Liposomes Delivered hFGF21 to Cortical and Hippocampal Microglia for Alzheimer's Disease Therapy., PMID:38513154
The muscle regeneration marker FOXP3 is associated with muscle injury in Duchenne muscular dystrophy., PMID:38388302
Rapamycin rescues loss of function in blood-brain barrier-interacting Tregs., PMID:38386413
[Association of ITGA4 and ICAM-1 gene polymorphisms with the risk and clinicopathological characteristics of Crohn's disease]., PMID:38311553
Etrolizumab-s fails to control E-Cadherin-dependent co-stimulation of highly activated cytotoxic T cells., PMID:38310086
Imaging Very Late Antigen-4 on MOLT4 Leukemia Tumors with Cysteine Site-Specific 89Zr-Labeled Natalizumab Immuno-Positron Emission Tomography., PMID:38282332
HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling., PMID:38254102
For research use only. Not for human or drug use.
