Catalog No.
RHK19103
Species reactivity
Human, Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:100, WB: 1:500-1:1000
Target
DOT1-like protein, Lysine N-methyltransferase 4, DOT1L, Histone-lysine N-methyltransferase, H3 lysine-79 specific, KMT4, H3-K79-HMTase, KIAA1814, Histone H3-K79 methyltransferase
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q8TEK3
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2L65
Preclinical targeting of leukemia-initiating cells in the development future biologics for acute myeloid leukemia., PMID:40304258
Chromatin Organization Governs Transcriptional Response and Plasticity of Cancer Stem Cells., PMID:40051293
Ocular Mucous Membrane Pemphigoid Demonstrates a Distinct Autoantibody Profile from Those of Other Autoimmune Blistering Diseases: A Preliminary Study., PMID:39584991
Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes., PMID:34253616
Inhibition of Dot1L Alleviates Fulminant Hepatitis Through Myeloid-Derived Suppressor Cells., PMID:33497867
The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses., PMID:33326791
Comprehensive exploratory autoantibody profiling in patients with early rheumatoid arthritis treated with methotrexate or tocilizumab., PMID:33301475
Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma., PMID:31304633
Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth., PMID:30356100
TALEN-Mediated FLAG-Tagging of Endogenous Histone Methyltransferase DOT1L., PMID:29796335
Emerging therapies for acute myeloid leukemia., PMID:28420416
Dot1l deficiency leads to increased intercalated cells and upregulation of V-ATPase B1 in mice., PMID:26404731
Novel agents for the treatment of childhood acute leukemia., PMID:25830014
An Af9 cis-element directly targets Dot1a to mediate transcriptional repression of the αENaC gene., PMID:23152297
Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l., PMID:23138183
The eleven-nineteen lysine-rich leukemia gene (ELL2) influences the histone H3 protein modifications accompanying the shift to secretory immunoglobulin heavy chain mRNA production., PMID:21832080
For research use only. Not for human or drug use.
