Catalog No.
RHK09202
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Target
Amino acid transport system xc-, SLC7A11, Cystine/glutamate transporter, Calcium channel blocker resistance protein CCBR1, Solute carrier family 7 member 11, xCT
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9UPY5
Applications
IF, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2L62
Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab-resistant HER2-positive breast cancer., PMID:40464376
Sulfasalazine combined with anti-IL-1β mAb induces ferroptosis and immune modulation in oral squamous cell carcinoma., PMID:40425823
Upregulation of ferroptosis in glucocorticoids-induced posterior subcapsular cataracts., PMID:40234585
Resveratrol alleviates testicular toxicity induced by anti-PD-1 through regulating the NRF2-SLC7A11-GPX4 pathway., PMID:40145083
Dulaglutide accelerates diabetic wound healing by suppressing Nrf2-dependent ferroptosis in diabetic mice., PMID:39954860
Effect of the glucagon-like peptide-1 receptor agonists dulaglutide on kidney outcomes in db/db mice., PMID:39805329
Enhancing Ferroptosis-Mediated Radiosensitization via Synergistic Disulfidptosis Induction., PMID:39727204
Therapeutic induction of ferroptosis in tumors using PD-L1 targeting antibody nanogel conjugates., PMID:39603241
Rituximab induces ferroptosis and RSL3 overcomes rituximab resistance in diffuse large B-cell lymphoma cells., PMID:39490616
xCT as a Predictor for Survival in a Population-Based Cohort of Head and Neck Squamous Cell Carcinoma., PMID:39487701
Chemokine CXCL13 facilitates anti-FVIII inhibitory antibody development in hemophilia A patients and murine models., PMID:39471695
Matrix stiffness-dependent PD-L2 deficiency improves SMYD3/xCT-mediated ferroptosis and the efficacy of anti-PD-1 in HCC., PMID:39159723
CX-5461 ameliorates disease in lupus-prone mice by triggering B-cell ferroptosis via p53-SLC7A11-ALOX12 pathway., PMID:39111584
Inhibition of ER stress using tauroursodeoxycholic acid rescues obesity-evoked cardiac remodeling and contractile anomalies through regulation of ferroptosis., PMID:38906502
Bevacizumab induces ferroptosis and enhances CD8+ T cell immune activity in liver cancer via modulating HAT1 and increasing IL-9., PMID:38760543
ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis., PMID:38756246
Correction: Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/ GPX4 expression., PMID:38693552
Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression., PMID:38600610
Targeting NKAα1 to treat Parkinson's disease through inhibition of mitophagy-dependent ferroptosis., PMID:38574977
Targeted activation of ferroptosis in colorectal cancer via LGR4 targeting overcomes acquired drug resistance., PMID:38291304
STING upregulation mediates ferroptosis and inflammatory response in lupus nephritis by upregulating TBK1 and activating NF-κB signal pathway., PMID:38186000
Influence of ferroptosis indicators on the stability of atherosclerotic plaque., PMID:38158665
Boosting the synergism between cancer ferroptosis and immunotherapy via targeted stimuli-responsive liposomes., PMID:38142469
Identification of Diagnosis and Typological Characteristics Associated with Ferroptosis for Ulcerative Colitis via Bioinformatics and Machine Learning., PMID:37957905
Targeting the Na+/K+ ATPase DR-region with DR-Ab improves doxorubicin-induced cardiotoxicity., PMID:37100355
Ferroptosis participates in dibutyl phthalate-aggravated allergic asthma in ovalbumin-sensitized mice., PMID:37018853
Ferroptosis and Neurodegenerative Diseases: Insights into the Regulatory Roles of SLC7A11., PMID:36988772
B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis., PMID:36907919
Effect of M2-like macrophages of the injured-kidney cortex on kidney cancer progression., PMID:36470862
Macrophage xCT deficiency drives immune activation and boosts responses to immune checkpoint blockade in lung cancer., PMID:36455758
Immunotherapy against the Cystine/Glutamate Antiporter xCT Improves the Efficacy of APR-246 in Preclinical Breast Cancer Models., PMID:36359363
Involvement of B-aat1 and Cbs in regulating mantle pigmentation in the Pacific oyster (Crassostrea gigas)., PMID:36335521
A novel circular RNA confers trastuzumab resistance in human epidermal growth factor receptor 2-positive breast cancer through regulating ferroptosis., PMID:35234341
15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation., PMID:34762602
IL-1β-Induced Elevation of Solute Carrier Family 7 Member 11 Promotes Hepatocellular Carcinoma Metastasis Through Up-regulating Programmed Death Ligand 1 and Colony-Stimulating Factor 1., PMID:34288020
Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition., PMID:33980655
Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice., PMID:32818320
Immunotargeting of the xCT Cystine/Glutamate Antiporter Potentiates the Efficacy of HER2-Targeted Immunotherapies in Breast Cancer., PMID:32532810
Combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation., PMID:32308771
The circadian clock protects against ferroptosis-induced sterile inflammation., PMID:32115146
Dysregulation of Glutamate Transport Enhances Treg Function That Promotes VEGF Blockade Resistance in Glioblastoma., PMID:31723000
Mapping of the cystine-glutamate exchanger in the mouse eye: a role for xCT in controlling extracellular redox balance., PMID:31396687
CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy., PMID:31043744
Bovine herpesvirus 4-based vector delivering the full length xCT DNA efficiently protects mice from mammary cancer metastases by targeting cancer stem cells., PMID:30524888
QSurface: fast identification of surface expression markers in cancers., PMID:29560830
A Virus-Like-Particle immunotherapy targeting Epitope-Specific anti-xCT expressed on cancer stem cell inhibits the progression of metastatic cancer in vivo., PMID:29399412
Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed., PMID:26494316
Effect of full flavor and denicotinized cigarettes exposure on the brain microvascular endothelium: a microarray-based gene expression study using a human immortalized BBB endothelial cell line., PMID:26099276
Genomic analysis of xCT-mediated regulatory network: Identification of novel targets against AIDS-associated lymphoma., PMID:25860939
[Expression levels of Slc7a11 in the skin of Kazakh sheep with different coat colors]., PMID:23099788
For research use only. Not for human or drug use.
