Catalog No.
RHK05001
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
WB: 1:500-1:1000
Target
EIF2AK3, HsPEK, PERK, PEK, PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, Eukaryotic translation initiation factor 2-alpha kinase 3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9NZJ5
Applications
WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2L55
CHIP suppresses the proliferation and migration of A549 cells by mediating the ubiquitination of eIF2α and upregulation of tumor suppressor RBM5., PMID:38272235
Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons., PMID:33341442
PERK-Mediated Unfolded Protein Response Signaling Restricts Replication of the Tick-Borne Flavivirus Langat Virus., PMID:32197325
Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway., PMID:30654386
Endoplasmic Reticulum Stress Markers and Their Possible Implications in Leprosy's Pathogenesis., PMID:30647798
A Flow Cytometric Study of ER Stress and Autophagy., PMID:30451364
New Hope for Pancreatic Ductal Adenocarcinoma Treatment Targeting Endoplasmic Reticulum Stress Response: A Systematic Review., PMID:30134550
Anti-ganglioside GD2 monoclonal antibody synergizes with cisplatin to induce endoplasmic reticulum-associated apoptosis in osteosarcoma cells., PMID:29442009
Nrf2 protects human lens epithelial cells against H2O2-induced oxidative and ER stress: The ATF4 may be involved., PMID:29421327
Imiquimod-induced autophagy is regulated by ER stress-mediated PKR activation in cancer cells., PMID:28601430
Endoplasmic reticulum stress pathway PERK-eIF2α confers radioresistance in oropharyngeal carcinoma by activating NF-κB., PMID:28418119
HMGB1 induces endothelial progenitor cells apoptosis via RAGE-dependent PERK/eIF2α pathway., PMID:28251435
Molecular signal networks and regulating mechanisms of the unfolded protein response., PMID:28070992
Niclosamide induced cell apoptosis via upregulation of ATF3 and activation of PERK in Hepatocellular carcinoma cells., PMID:26917416
Inhibition of endoplasmic reticulum chaperone protein glucose-regulated protein 78 potentiates anti-angiogenic therapy in renal cell carcinoma through inactivation of the PERK/eIF2α pathway., PMID:26472187
Early Neurodegeneration in the Brain of a Child Without Functional PKR-like Endoplasmic Reticulum Kinase., PMID:26172286
Pancreatic endoplasmic reticulum kinase activation promotes medulloblastoma cell migration and invasion through induction of vascular endothelial growth factor A., PMID:25794107
Deficiency of IRE1 and PERK signal pathways in systemic lupus erythematosus., PMID:25226532
Role of ATF3 in synergistic cancer cell killing by a combination of HDAC inhibitors and agonistic anti-DR5 antibody through ER stress in human colon cancer cells., PMID:24530917
Short stature in child with early-onset diabetes., PMID:23644647
For research use only. Not for human or drug use.
