Catalog No.
YHC97501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp218-Glu444
Predicted molecular weight
26.88 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P13489
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RNH, Placental ribonuclease inhibitor, PRI, Placental RNase inhibitor, Ribonuclease/angiogenin inhibitor 1, RAI, RNH1, Ribonuclease inhibitor
RNase1-driven ALK-activation is an oncogenic driver and therapeutic target in non-small cell lung cancer., PMID:40246819
Revealing the Oxidative Stress-Related Molecular Characteristics and Potential Therapeutic Targets of Schizophrenia through Integrated Gene Expression Data Analysis., PMID:40214957
Epitope-focused vaccine immunogens design using tailored horseshoe-shaped scaffold., PMID:39966941
PCNA and Rnh1 independently participate in the protection of mitochondrial genome against UV-induced mutagenesis in yeast cells., PMID:39730600
The Antipsychotic Drug Aripiprazole Suppresses Colorectal Cancer by Targeting LAMP2a to Induce RNH1/miR-99a/mTOR-Mediated Autophagy and Apoptosis., PMID:39513392
Global coupling of R-loop dynamics with RNA polymerase II modulates gene expression and early development of Drosophila., PMID:39470713
Ribonuclease inhibitor 1 emerges as a potential biomarker and modulates inflammation and iron homeostasis in sepsis., PMID:38951571
Ribonuclease inhibitor and angiogenin system regulates cell type-specific global translation., PMID:38820160
Proteomics of tumor and serum samples from isocitrate dehydrogenase-wildtype glioblastoma patients: is the detoxification of reactive oxygen species associated with shorter survival?, PMID:38803161
New link between RNH1 and E2F1: regulates the development of lung adenocarcinoma., PMID:38783241
AZGP1 deficiency promotes angiogenesis in prostate cancer., PMID:38659028
Tailoring the stress response of human skin cells by substantially limiting the nuclear localization of angiogenin., PMID:38317956
Engineering Human Pancreatic RNase 1 as an Immunotherapeutic Agent for Cancer Therapy Through Computational and Experimental Studies., PMID:38145445
Dissection of paracrine/autocrine interplay in lung tumor microenvironment mimicking cancer cell-monocyte co-culture models reveals proteins that promote inflammation and metastasis., PMID:37784035
Functional status analysis of RNH1 in bladder cancer for predicting immunotherapy response., PMID:37537337
APOBEC3B coordinates R-loop to promote replication stress and sensitize cancer cells to ATR/Chk1 inhibitors., PMID:37270643
Biallelic variants in ribonuclease inhibitor (RNH1), an inflammasome modulator, are associated with a distinctive subtype of acute, necrotizing encephalopathy., PMID:37191094
Human molecular genetics sheds light on the physiological significance of ribonuclease inhibitor (RNH1)., PMID:37085604
Ribonuclease inhibitor 1 (RNH1) deficiency cause congenital cataracts and global developmental delay with infection-induced psychomotor regression and anemia., PMID:36935417
DNA-RNA Hybrids at Telomeres in Budding Yeast., PMID:35704190
LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity., PMID:35256513
IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis., PMID:34781942
Salmonella Typhimurium infection causes defects and fastening of Caenorhabditis elegans developmental stages., PMID:34756991
Association of Clinicopathologic and Molecular Tumor Features With Recurrence in Resected Early-Stage Epidermal Growth Factor Receptor-Positive Non-Small Cell Lung Cancer., PMID:34739062
A concise review on the role of BDNF-AS in human disorders., PMID:34426254
DNA-RNA hybrids at DSBs interfere with repair by homologous recombination., PMID:34236317
Angiogenin (ANG)-Ribonuclease Inhibitor (RNH1) System in Protein Synthesis and Disease., PMID:33525475
R-loops at centromeric chromatin contribute to defects in kinetochore integrity and chromosomal instability in budding yeast., PMID:33147102
The cell and stress-specific canonical and noncanonical tRNA cleavage., PMID:33043995
RNA-cDNA hybrids mediate transposition via different mechanisms., PMID:32994470
Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade., PMID:32521278
Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis., PMID:32213712
Evolutionary History and Activity of RNase H1-Like Proteins in Arabidopsis thaliana., PMID:32191307
Transcription-replication conflicts as a source of common fragile site instability caused by BMI1-RNF2 deficiency., PMID:32142505
Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability., PMID:32075754
FOLFOX treatment response prediction in metastatic or recurrent colorectal cancer patients via machine learning algorithms., PMID:31893575
Discovery of potential plasma protein biomarkers for acute myocardial infarction via proteomics., PMID:31656670
MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts., PMID:31537797
Regulation of IRE1 RNase activity by the Ribonuclease inhibitor 1 (RNH1)., PMID:30109813
Human angiogenin is a potent cytotoxin in the absence of ribonuclease inhibitor., PMID:29748193
RNase H eliminates R-loops that disrupt DNA replication but is nonessential for efficient DSB repair., PMID:29622660
Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation., PMID:29408805
Human ribonuclease H1 resolves R-loops and thereby enables progression of the DNA replication fork., PMID:28717002
Designing the Sniper: Improving Targeted Human Cytolytic Fusion Proteins for Anti-Cancer Therapy via Molecular Simulation., PMID:28536352
The role of angiogenesis in Group 3 medulloblastoma pathogenesis and survival., PMID:28379574
Knockout of the Ribonuclease Inhibitor Gene Leaves Human Cells Vulnerable to Secretory Ribonucleases., PMID:27806571
Interplay between intergrin-linked kinase and ribonuclease inhibitor affects growth and metastasis of bladder cancer through signaling ILK pathways., PMID:27576342
Engineered human angiogenin mutations in the placental ribonuclease inhibitor complex for anticancer therapy: Insights from enhanced sampling simulations., PMID:27110669
Novel angiogenin mutants with increased cytotoxicity enhance the depletion of pro-inflammatory macrophages and leukemia cells ex vivo., PMID:26472728
Angiogenin mutants as novel effector molecules for the generation of fusion proteins with increased cytotoxic potential., PMID:25710248
For research use only. Not for human or drug use.
