Catalog No.
RHJ66601
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000
Target
Protein Drosha, DROSHA, Ribonuclease III, RNASE3L, RNASEN, RN3, RNase III, Ribonuclease 3, p241
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9NRR4
Applications
FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2K44
Adenovirus VA RNAs impair maturation of primary microRNA., PMID:37434327
Peptidylarginine deiminase 2 regulates expression of DGCR8 affecting miRNA biogenesis in gonadotrope cells., PMID:37310889
The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response., PMID:36591274
Immunohistochemical expression of Drosha is reduced in eutopic and ectopic endometrium of women with adenomyosis., PMID:36515351
MicroRNA and interleukin 6 interplay in the adipose tissue of rheumatoid arthritis patients., PMID:35579086
SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: a new route of epigenomic regulation., PMID:28358001
miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation., PMID:27880903
DICER and DROSHA gene expression and polymorphisms in autoimmune thyroid diseases., PMID:27808570
CRISPR/Cas9 Targets Chicken Embryonic Somatic Cells In Vitro and In Vivo and generates Phenotypic Abnormalities., PMID:27694906
Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression., PMID:26725326
Identification of precursor microRNAs within distal axons of sensory neuron., PMID:25919946
Downregulated expression of Dicer1 predicts inferior survival in primary gastrointestinal diffuse large B-cell lymphoma treated with CHOP-like regimen and rituximab., PMID:25195038
Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage., PMID:24379358
Expression of the RNase III enzyme DROSHA is reduced during progression of human cutaneous melanoma., PMID:23370771
Dicer and Drosha expression and response to Bevacizumab-based therapy in advanced colorectal cancer patients., PMID:23266047
The RNA binding protein SAM68 transiently localizes in the chromatoid body of male germ cells and influences expression of select microRNAs., PMID:22745822
Repression of GW/P body components and the RNAi microprocessor impacts primary ciliogenesis in human astrocytes., PMID:21880135
Expression of the ribonucleases Drosha, Dicer, and Ago2 in colorectal carcinomas., PMID:21769619
Experimental identification of microRNA targets by immunoprecipitation of Argonaute protein complexes., PMID:21431712
Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells., PMID:19633292
Functional association of the Microprocessor complex with the spliceosome., PMID:19349299
EGO-1, a putative RNA-dependent RNA polymerase, is required for heterochromatin assembly on unpaired dna during C. elegans meiosis., PMID:16271877
For research use only. Not for human or drug use.
