Catalog No.
RHJ57002
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:100-1:200, WB: 1:1000-1:2000
Target
HSN2, Erythrocyte 65 kDa protein, Protein kinase lysine-deficient 1, KDP, p65, hWNK1, KIAA0344, Kinase deficient protein, Protein kinase with no lysine 1, Serine/threonine-protein kinase WNK1, PRKWNK1, WNK1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9H4A3
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2K22
WNK1-dependent water influx is required for CD4+ T cell activation and T cell-dependent antibody responses., PMID:39984435
L-Wnk1 Deletion in Smooth Muscle Cells Causes Aortitis and Inflammatory Shift., PMID:38979610
Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma., PMID:38722741
B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice., PMID:36662229
Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1., PMID:32413057
ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms., PMID:31291965
Genetic predisposition to bevacizumab-induced hypertension., PMID:28969913
WNK1 and p38-MAPK distribution in ionocytes and accessory cells of euryhaline teleost fish implies ionoregulatory function., PMID:28522431
Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC., PMID:27009335
Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3., PMID:26435498
Genetic markers of bevacizumab-induced hypertension., PMID:24558090
WNK1 is required for mitosis and abscission., PMID:21220314
Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension., PMID:20921400
Oncoproteomic analysis reveals co-upregulation of RELA and STAT5 in carboplatin resistant ovarian carcinoma., PMID:20585448
Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific., PMID:19001526
Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells., PMID:15799971
WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate., PMID:14611643
WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia., PMID:12522152
For research use only. Not for human or drug use.
