Catalog No.
RHJ44201
Species reactivity
Human, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:100, WB: 1:500-1:1000
Target
Neurotensin receptor 3, Gp95, Glycoprotein 95, Sortilin, 100 kDa NT receptor, NTR3, SORT1, NT3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q99523
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2J83
Function and application of brain‑derived neurotrophic factor precursors (Review)., PMID:40341415
SORL1-Mediated EGFR and FGFR4 Regulation Enhances Chemoresistance in Ovarian Cancer., PMID:39858026
Ex vivo nanoscale abluminal mapping of putative cargo receptors at the blood-brain barrier of expanded brain capillaries., PMID:39402596
Designed endocytosis-inducing proteins degrade targets and amplify signals., PMID:39322662
Propolis Reduces Inflammation and Dyslipidemia Caused by High-Cholesterol Diet in Mice by Lowering ADAM10/17 Activities., PMID:38931216
Phase 1 study of latozinemab in progranulin-associated frontotemporal dementia., PMID:38356474
A Genome-Wide CRISPR Screen Identifies Sortilin as the Receptor Responsible for Galectin-1 Lysosomal Trafficking., PMID:38260508
Generation and Characterization of SORT1-Targeted Antibody-Drug Conjugate for the Treatment of SORT1-Positive Breast Tumor., PMID:38139459
Generation of a Novel SORT1×HER2 Bispecific Antibody-Drug Conjugate Targeting HER2-Low-Expression Tumor., PMID:38003245
Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier., PMID:37932749
Tracking of Prosaposin, a Saposin Precursor, in Rat Testis., PMID:37728096
Epitope mapping of nanobodies binding the Alzheimer's disease receptor SORLA., PMID:37634829
Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia., PMID:37322482
Sortilin acts as an endocytic receptor for α-synuclein fibril., PMID:37272890
Sortilin Inhibition Protects Neurons From Degeneration in the Diabetic Retina., PMID:37272764
A magnetic antibody-conjugated nano-system for selective delivery of Ca(OH)2 and taxotere in ovarian cancer cells., PMID:36130999
Aberrant protein expression of Appl1, Sortilin and Syndecan-1 during the biological progression of prostate cancer., PMID:36089417
Intraneuronal sortilin aggregation relative to granulovacuolar degeneration, tau pathogenesis and sorfra plaque formation in human hippocampal formation., PMID:35978952
Monoclonal Antibody Against Sortilin Induces Apoptosis in Human Breast Cancer Cells., PMID:35509360
Diagnostic and Therapeutic Implications of Sortilin Expressed on the Surface of Bladder Carcinoma Cells., PMID:35463727
New Peptide-Drug Conjugates for Precise Targeting of SORT1-Mediated Vasculogenic Mimicry in the Tumor Microenvironment of TNBC-Derived MDA-MB-231 Breast and Ovarian ES-2 Clear Cell Carcinoma Cells., PMID:34751242
Sortilin-related receptor is a druggable therapeutic target in breast cancer., PMID:34564954
Plasmonic photothermal release of docetaxel by gold nanoparticles incorporated onto halloysite nanotubes with conjugated 2D8-E3 antibodies for selective cancer therapy., PMID:34380469
The expression of prosaposin and its receptors, GRP37 and GPR37L1, are increased in the developing dorsal root ganglion., PMID:34379697
Tweaking Progranulin Expression: Therapeutic Avenues and Opportunities., PMID:34366786
Neurotensin: A novel mediator of ovulation?, PMID:33710668
Oxidized low-density lipoprotein activates extracellular signal-regulated kinase signaling to downregulate sortilin expression in liver sinusoidal endothelial cells., PMID:33694195
The multifaceted role of sortilin/neurotensin receptor 3 in human cancer development., PMID:33634506
Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation., PMID:33384578
Prosaposin in the rat oviductal epithelial cells., PMID:33242172
Physiology and role of PCSK9 in vascular disease: Potential impact of localized PCSK9 in vascular wall., PMID:32875580
Extracellular Sortilin Proteopathy Relative to β-Amyloid and Tau in Aged and Alzheimer's Disease Human Brains., PMID:32477092
The Association Between Sortilin and Inflammation in Patients with Coronary Heart Disease., PMID:32104044
Sortilin as a Novel Diagnostic and Therapeutic Biomarker in Chronic Lymphocytic Leukemia., PMID:31908734
Neurotoxicity of antibodies in cancer therapy: A review., PMID:31731087
Increased cardiovascular and atherosclerosis markers in blood of older patients with atopic dermatitis., PMID:31622668
Antidepressant Drugs Correct the Imbalance Between proBDNF/p75NTR/Sortilin and Mature BDNF/TrkB in the Brain of Mice with Chronic Stress., PMID:31493120
Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain., PMID:31223654
SORLA regulates endosomal trafficking and oncogenic fitness of HER2., PMID:31138794
Loss of TrkB Signaling Due to Status Epilepticus Induces a proBDNF-Dependent Cell Death., PMID:30800056
proBDNF inhibits the proliferation and migration of OLN‑93 oligodendrocytes., PMID:30132570
Pro-BDNF Contributes to Hypoxia/Reoxygenation Injury in Myocardial Microvascular Endothelial Cells: Roles of Receptors p75NTR and Sortilin and Activation of JNK and Caspase 3., PMID:30046375
Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer's disease model mice and macaques., PMID:29690919
Detection of retromer assembly in Plasmodium falciparum by immunosensing coupled to Surface Plasmon Resonance., PMID:29654975
Inhibition of insulin/PI3K/AKT signaling decreases adipose Sortilin 1 in mice and 3T3-L1 adipocytes., PMID:28844948
Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations., PMID:28828399
Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum., PMID:28638323
ProBDNF inhibits proliferation, migration and differentiation of mouse neural stem cells., PMID:28528122
Binding of thyroglobulin (Tg) to the low-density lipoprotein receptor-associated protein (RAP) during the biosynthetic pathway prevents premature Tg interactions with sortilin., PMID:28382504
A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA)., PMID:27998951
For research use only. Not for human or drug use.
