Catalog No.
RHJ43502
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
WB: 1:500-1:1000
Target
NOTCH4, INT3, hNotch4, Neurogenic locus notch homolog protein 4, Notch 4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q99466
Applications
WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2J80
Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium., PMID:38984877
The Clinical Application of Immunohistochemical Expression of Notch4 Protein in Patients with Colon Adenocarcinoma., PMID:37108670
Circulating Tumor DNA Identifies Diverse Landscape of Acquired Resistance to Anti-Epidermal Growth Factor Receptor Therapy in Metastatic Colorectal Cancer., PMID:36007218
A common IL-4 receptor variant promotes asthma severity via a Treg cell GRB2-IL-6-Notch4 circuit., PMID:35841382
Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections., PMID:33915108
Hematological and Genetic Markers in the Rational Approach to Patients With HCV Sustained Virological Response With or Without Persisting Cryoglobulinemic Vasculitis., PMID:33721342
Precision medicine for human cancers with Notch signaling dysregulation (Review)., PMID:31894255
Quartz crystal microbalance biosensor for label-free MDA MB 231 cancer cell detection via notch-4 receptor., PMID:31357373
Associations of Multiple NOTCH4 Exonic Variants with Systemic Sclerosis., PMID:30442821
Alterations of Notch pathway in patients with adenoid cystic carcinoma of the trachea and its impact on survival., PMID:29858025
A Jagged 1-Notch 4 molecular switch mediates airway inflammation induced by ultrafine particles., PMID:29627423
Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion., PMID:29386132
Notch Ligand Binding Assay Using Flow Cytometry., PMID:29333477
Short Pulse of Clinical Concentration of Bevacizumab Modulates Human Retinal Pigment Epithelial Functionality., PMID:26975025
Notch signaling mediates crosstalk between endothelial cells and macrophages via Dll4 and IL6 in cardiac microvascular inflammation., PMID:26826491
Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β., PMID:26646450
Cripto-1 as a novel therapeutic target for triple negative breast cancer., PMID:26059540
Endothelial Jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4/Notch1., PMID:25767274
Clinicopathological significance of aberrant Notch receptors in intrahepatic cholangiocarcinoma., PMID:25031748
Genome-wide association study of hepatitis C virus- and cryoglobulin-related vasculitis., PMID:25030430
Nicastrin and Notch4 drive endocrine therapy resistance and epithelial to mesenchymal transition in MCF7 breast cancer cells., PMID:24919951
Notch1 and 4 signaling responds to an increasing vascular wall shear stress in a rat model of arteriovenous malformations., PMID:24563863
The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors., PMID:24145721
Implications of Dll4-Notch signaling activation in primary glioblastoma multiforme., PMID:23787764
Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4)., PMID:23675950
Expression of immune genes on chromosome 6p21.3-22.1 in schizophrenia., PMID:23395714
Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations., PMID:23388056
Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy., PMID:22829975
Expression of Notch receptors and ligands on immature and mature T cells., PMID:22310713
Regulation of experimental autoimmune uveoretinitis by anti-delta-like ligand 4 monoclonal antibody., PMID:21896864
Modulation of endothelial cell network formation in vitro by molecular signaling of head and neck squamous cell carcinoma (HNSCC) exposed to cetuximab., PMID:21820450
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy., PMID:21779181
Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus., PMID:20662065
Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors., PMID:20161710
A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma., PMID:20069356
Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease., PMID:19546852
Human umbilical cord epithelial cells express Notch1: implications for its epidermal-like differentiation., PMID:17851046
Venous identity is lost but arterial identity is not gained during vein graft adaptation., PMID:17463332
Immunohistological localization of Notch receptors and their ligands Delta and Jagged in synovial tissues of rheumatoid arthritis., PMID:16307184
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells., PMID:15535842
Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways., PMID:14701863
Induction of Notch signaling by tumor necrosis factor in rheumatoid synovial fibroblasts., PMID:14586405
A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling., PMID:12482954
Cortisol regulates the expression of Notch in osteoblasts., PMID:11948681
Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation., PMID:11909975
Expression of notch homologues in the synovium of rheumatoid arthritis and osteoarthritis patients., PMID:11678296
Interactions between fibroblast growth factors and Notch regulate neuronal differentiation., PMID:11466430
For research use only. Not for human or drug use.
