Catalog No.
RHJ32901
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, WB: 1:1000-1:2000
Target
High-temperature requirement A serine peptidase 1, Serine protease 11, HTRA1, PRSS11, HTRA, Serine protease HTRA1, L56
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q92743
Applications
IF, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2J46
Phase 2 Study of the Anti-High Temperature Requirement A1 (HtrA1) Fab Galegenimab (FHTR2163) in Geographic Atrophy Secondary to Age-Related Macular Degeneration., PMID:40089174
A reliable clinical test for detection of membranous nephropathy antigens using laser microdissection and mass spectrometry., PMID:39197586
Altered Elastin Turnover, Immune Response, and Age-Related Retinal Thinning in a Transgenic Mouse Model With RPE-Specific HTRA1 Overexpression., PMID:39028977
Genetics in neovascular age-related macular degeneration susceptibility and treatment response to anti-VEGF intravitreal injection: A case series study., PMID:38757252
Disulfide-constrained peptide scaffolds enable a robust peptide-therapeutic discovery platform., PMID:38547109
Secretome from Magnetically Stimulated Muscle Exhibits Anticancer Potency: Novel Preconditioning Methodology Highlighting HTRA1 Action., PMID:38474424
Influence of Genetic Polymorphisms on the Short-Term Response to Ranibizumab in Patients With Neovascular Age-Related Macular Degeneration., PMID:37862026
Exploring the Therapeutic Potential of Elastase Inhibition in Age-Related Macular Degeneration in Mouse and Human., PMID:37174708
The expanding spectrum and utility of antigens in membranous nephropathy., PMID:36811646
["New antigens" in membranous glomerulonephritis: let's take a closer look]., PMID:36563071
Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration., PMID:36064790
Pediatric membranous nephropathy: In the novel antigens era., PMID:36016931
Hematopoietic Stem Cell Transplant-Membranous Nephropathy Is Associated with Protocadherin FAT1., PMID:35321939
Modulated anti-VEGF therapy under the influence of lipid metabolizing proteins in Age related macular degeneration: a pilot study., PMID:35027571
Phase 1 Study of the Anti-HtrA1 Antibody-binding Fragment FHTR2163 in Geographic Atrophy Secondary to Age-related Macular Degeneration., PMID:34214452
Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy., PMID:33952630
Current Management and Therapeutic Strategies for Cerebral Amyloid Angiopathy., PMID:33918041
Identification of hub genes and key pathways in the emphysema phenotype of COPD., PMID:33535173
Nonclinical Safety Assessment of FHTR2163, An Antigen-Binding Fragment Against HTRA1 for the Treatment of Geographic Atrophy., PMID:33297886
Genetic Variants Affecting Anti-VEGF Drug Response in Polypoidal Choroidal Vasculopathy Patients: A Systematic Review and Meta-Analysis., PMID:33198211
BETA-PERIPAPILLARY ATROPHY AND GEOGRAPHIC ATROPHY IN THE COMPARISON OF AGE-RELATED MACULAR DEGENERATION TREATMENTS TRIALS., PMID:32383840
Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy., PMID:32345717
Incidence and Progression of Nongeographic Atrophy in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Clinical Trial., PMID:32191267
Loss of the serine protease HTRA1 impairs smooth muscle cells maturation., PMID:31796853
Protease Nexin I is a feedback regulator of EGF/PKC/MAPK/EGR1 signaling in breast cancer cells metastasis and stemness., PMID:31501409
HTRA1 synergizes with oxidized phospholipids in promoting inflammation and macrophage infiltration essential for ocular VEGF expression., PMID:31100080
Identification and tracking of problematic host cell proteins removed by a synthetic, highly functionalized nonwoven media in downstream bioprocessing of monoclonal antibodies., PMID:30898377
Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects., PMID:30795802
Immune response against HtrA proteases in children with cutaneous mastocytosis., PMID:30148508
High-Temperature Requirement A1 (Htra1) - A Novel Regulator of Canonical Wnt Signaling., PMID:29269789
A prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration., PMID:28835685
HTRA1 and TGF-β1 Concentrations in the Aqueous Humor of Patients With Neovascular Age-Related Macular Degeneration., PMID:28114575
Blood biomarkers in a mouse model of CADASIL., PMID:27174004
The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody., PMID:26385991
Assessment of Proteins Associated With Complement Activation and Inflammation in Maculae of Human Donors Homozygous Risk at Chromosome 1 CFH-to-F13B., PMID:26218915
Production, secretion and purification of a correctly folded staphylococcal antigen in Lactococcus lactis., PMID:26178240
Bevacizumab treatment for neovascular age-related macular degeneration in the setting of a clinic: "real life" long-term outcome., PMID:25881145
Pharmacogenomics of response to anti-VEGF therapy in exudative age-related macular degeneration., PMID:25635578
Pharmacogenetic associations with long-term response to anti-vascular endothelial growth factor treatment in neovascular AMD patients., PMID:25558172
Growth of geographic atrophy in the comparison of age-related macular degeneration treatments trials., PMID:25542520
Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities., PMID:25248123
Overexpression of HtrA1 and exposure to mainstream cigarette smoke leads to choroidal neovascularization and subretinal deposits in aged mice., PMID:25205867
Comparison of drusen and modifying genes in autosomal dominant radial drusen and age-related macular degeneration., PMID:25077532
Shark Attack: high affinity binding proteins derived from shark vNAR domains by stepwise in vitro affinity maturation., PMID:24862193
Predictors of anti-VEGF treatment response in neovascular age-related macular degeneration., PMID:24332379
[Contemporary pharmacogenetic approaches to the treatment of age-related macular degeneration]., PMID:24261289
Risk of geographic atrophy in the comparison of age-related macular degeneration treatments trials., PMID:24084496
Genetic association with response to intravitreal ranibizumab for neovascular age-related macular degeneration in the Han Chinese population., PMID:24080590
Pharmacogenetics of the treatment response of age-related macular degeneration with ranibizumab and bevacizumab., PMID:24010796
Lipopolysaccharide increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA-1 expression., PMID:23982886
For research use only. Not for human or drug use.
