Catalog No.
RHJ29101
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IP: 1:20, WB: 1:500-1:1000
Target
FGFR substrate 2, FRS2, Fibroblast growth factor receptor substrate 2, FGFR-signaling adaptor SNT, Suc1-associated neurotrophic factor target 1, SNT-1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q8WU20
Applications
IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2J29
Expression and Purification of FGFR1-Fc Fusion Protein and Its Effects on Human Lung Squamous Carcinoma., PMID:37160564
Inflammatory cytokine-enriched microenvironment plays key roles in the development of breast cancers., PMID:36704829
Systematic pharmacological analysis of agonistic and antagonistic fibroblast growth factor receptor 1 MAbs reveals a similar unique mode of action., PMID:36410439
Identification of GPC3 mutation and upregulation in a multidrug resistant osteosarcoma and its spheroids as therapeutic target., PMID:34611509
Preclinical Development of U3-1784, a Novel FGFR4 Antibody Against Cancer, and Avoidance of Its On-target Toxicity., PMID:31350344
FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway., PMID:28771231
Identification of Pharmacodynamic Transcript Biomarkers in Response to FGFR Inhibition by AZD4547., PMID:27550940
The Prozone Effect Accounts for the Paradoxical Function of the Cdk-Binding Protein Suc1/Cks., PMID:26854218
The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival., PMID:24445144
Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models., PMID:23343422
Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma., PMID:22027573
The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons., PMID:19943849
Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice., PMID:19381019
Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles., PMID:19187780
Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models., PMID:17599042
ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation., PMID:17274988
Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades., PMID:16940750
Entire mitogen activated protein kinase (MAPK) pathway is present in preimplantation mouse embryos., PMID:15305288
Induction of apoptosis in cultured endothelial cells by a cadherin antagonist peptide: involvement of fibroblast growth factor receptor-mediated signalling., PMID:15023527
N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling., PMID:11433297
The mitogenic signaling pathway for fibroblast growth factor-2 involves the tyrosine phosphorylation of cyclin D2 in MCF-7 human breast cancer cells., PMID:10930570
Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck., PMID:10428862
For research use only. Not for human or drug use.
