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Anti-FRS2 Antibody (R2J28)

Catalog #:   RHJ29102 Specific References (22) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: FCM, IP, WB
Accession: Q8WU20
Overview

Catalog No.

RHJ29102

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

FCM: 1:20-1:100, IP: 1:20-1:50, WB: 1:1000-1:2000

Target

FGFR substrate 2, FRS2, Fibroblast growth factor receptor substrate 2, FGFR-signaling adaptor SNT, Suc1-associated neurotrophic factor target 1, SNT-1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q8WU20

Applications

FCM, IP, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.

Clone ID

R2J28

Data Image
  • Western blot
    Western blot analysis of FRS2 expression in HeLa cell lysate.
References

Expression and Purification of FGFR1-Fc Fusion Protein and Its Effects on Human Lung Squamous Carcinoma., PMID:37160564

Inflammatory cytokine-enriched microenvironment plays key roles in the development of breast cancers., PMID:36704829

Systematic pharmacological analysis of agonistic and antagonistic fibroblast growth factor receptor 1 MAbs reveals a similar unique mode of action., PMID:36410439

Identification of GPC3 mutation and upregulation in a multidrug resistant osteosarcoma and its spheroids as therapeutic target., PMID:34611509

Preclinical Development of U3-1784, a Novel FGFR4 Antibody Against Cancer, and Avoidance of Its On-target Toxicity., PMID:31350344

FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway., PMID:28771231

Identification of Pharmacodynamic Transcript Biomarkers in Response to FGFR Inhibition by AZD4547., PMID:27550940

The Prozone Effect Accounts for the Paradoxical Function of the Cdk-Binding Protein Suc1/Cks., PMID:26854218

The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival., PMID:24445144

Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models., PMID:23343422

Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma., PMID:22027573

The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons., PMID:19943849

Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice., PMID:19381019

Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles., PMID:19187780

Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models., PMID:17599042

ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation., PMID:17274988

Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades., PMID:16940750

Entire mitogen activated protein kinase (MAPK) pathway is present in preimplantation mouse embryos., PMID:15305288

Induction of apoptosis in cultured endothelial cells by a cadherin antagonist peptide: involvement of fibroblast growth factor receptor-mediated signalling., PMID:15023527

N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling., PMID:11433297

The mitogenic signaling pathway for fibroblast growth factor-2 involves the tyrosine phosphorylation of cyclin D2 in MCF-7 human breast cancer cells., PMID:10930570

Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck., PMID:10428862

Datasheet

Document Download

Anti-FRS2 Antibody (R2J28).pdf

 

$ 290
Product specifications
50 μg 290 100 μg 484

Contact Information

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For research use only. Not for human or drug use.

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Anti-FRS2 Antibody (R2J28) [RHJ29102]
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