Catalog No.
RHG89501
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Target
Signal transducer and activator of transcription 4, STAT4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q14765
Applications
IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2F78
Triple positivity for autoantibodies in patients with rheumatoid arthritis is associated with a severe course of the disease but not with bone turnover markers., PMID:40485950
An activating Stat1 mutant disrupts normal STAT4 innate lymphocyte programs during viral infection., PMID:40446018
Systemic Sclerosis and Primary Biliary Cholangitis: A Comprehensive Review of Two Overlapping Rare Entities With Insights on Diagnostics and Management., PMID:40351968
Self-assembling sequentially administered tumor targeted Split IL-12p35 and p40 subunits to improve the therapeutic index of systemically delivered IL-12 therapy for cancer., PMID:40154091
Taming interleukin-12: Engineering of bispecific antibody-based IL-12 mimetics with biased agonism capacities., PMID:39981925
Borrelia burgdorferi sensu lato inhibits CIITA transcription through pSTAT3 activation and enhanced SOCS1 and SOCS3 expression leading to limited IFN-γ production., PMID:39879745
Interaction between interleukin-12 (IL-12) and its receptor (IL-12Rβ2) mediates CD4+ T cell subsets activation in flounder (Paralichthys olivaceus)., PMID:39743087
Irisin Improves Preeclampsia by Promoting Embryo Implantation and Vascular Remodeling., PMID:39540296
Genes deregulated in giant cell arteritis by Nanostring nCounter gene expression profiling in temporal artery biopsies., PMID:39317454
STAT4 and STAT6, their role in cellular and humoral immunity and in diverse human diseases., PMID:39188021
Anti-IL12p40 autoantibodies in a teenage girl with multiple recurrent abscesses., PMID:39098705
A Genome-Wide Association Study Suggests New Susceptibility Loci for Primary Antiphospholipid Syndrome., PMID:38973605
IL-12 drives the differentiation of human T follicular regulatory cells., PMID:38968337
Cordyceps protein alleviates renal injury by inhibiting T cell infiltration and Th1 cell differentiation in lupus nephritis mice., PMID:38943968
Hirsutella sinensis polysaccharides and Parabacteroides goldsteinii reduce lupus severity in imiquimod-treated mice., PMID:38901796
Machine learning-based prediction of rheumatoid arthritis with development of ACPA autoantibodies in the presence of non-HLA genes polymorphisms., PMID:38517871
A genome-wide association study suggests new susceptibility loci for primary antiphospholipid syndrome., PMID:38405993
STAT4 Gene Variant rs7574865 Is Associated with Rheumatoid Arthritis Activity and Anti-CCP Levels in the Western but Not in the Southern Population of Mexico., PMID:38397230
Evaluation of transcription factors and cytokine expressions of T-cell subsets in CD19 deficiency and their possible relationship with autoimmune disease., PMID:38095318
Hepatitis C virus modified sE2F442NYT as an antigen in candidate vaccine facilitates human immune cell activation., PMID:38084956
TOX, TWIST1, STAT4, and SATB1 protein expressions in early-stage mycosis fungoides., PMID:37932931
Biomarkers in Systemic Sclerosis: An Overview., PMID:37886934
Biomarkers in the Pathogenesis, Diagnosis, and Treatment of Systemic Sclerosis., PMID:37868834
Identification of lactate regulation pattern on tumor immune infiltration, therapy response, and DNA methylation in diffuse large B-cell lymphoma., PMID:37790933
Association Between Plasma Rituximab Concentration and the Risk of Major Relapse in Antineutrophil Cytoplasmic Antibody-Associated Vasculitides During Rituximab Maintenance Therapy., PMID:37134130
Preventing Surgery-Induced NK Cell Dysfunction Using Anti-TGF-β Immunotherapeutics., PMID:36498937
Myelin oligodendrocyte glycoprotein-associated disease is associated with BANK1, RNASET2 and TNIP1 polymorphisms., PMID:36054934
Non-HLA Gene Polymorphisms in the Pathogenesis of Type 1 Diabetes: Phase and Endotype Specific Effects., PMID:35812428
Association Study of Anticitrullinated Peptide Antibody Status with Clinical Manifestations and SNPs in Patients Affected with Rheumatoid Arthritis: A Pilot Study., PMID:35601739
Transcription Factors and Regulators Pathway-focused Genes Expression Analysis in Patients with Different Forms of Thyroid Pathology., PMID:35176984
The diagnostic role of PD-1+ CXCR5+ follicular helper CD8+ T cell in renal allograft dysfunction., PMID:34957609
Ubiquitinated Hepatitis D Antigen-Loaded Microvesicles Induce a Potent Specific Cellular Immune Response to Inhibit HDV Replication in Vivo., PMID:34908456
KDP, a Lactobacilli Product from Kimchi, Enhances Mucosal Immunity by Increasing Secretory IgA in Mice and Exhibits Antimicrobial Activity., PMID:34836191
Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation., PMID:34471108
Abnormalities of the type I interferon signaling pathway in lupus autoimmunity., PMID:34340046
Association of the STAT4, CDKN1A, and IRF5 variants with risk of lupus nephritis and renal biopsy classification in patients in Vietnam., PMID:33687153
Myeloid-derived suppressor cell (MDSC) key genes analysis in rat anti-CD28-induced immune tolerance kidney transplantation., PMID:33532310
Type I Interferon-Activated STAT4 Regulation of Follicular Helper T Cell-Dependent Cytokine and Immunoglobulin Production in Lupus., PMID:33512094
STAT4 Is Largely Dispensable for Systemic Lupus Erythematosus-like Autoimmune- and Foreign Antigen-Driven Antibody-Forming Cell, Germinal Center, and Follicular Th Cell Responses., PMID:33446493
Anti-S100A4 Antibody Therapy Is Efficient in Treating Aggressive Prostate Cancer and Reversing Immunosuppression: Serum and Biopsy S100A4 as a Clinical Predictor., PMID:32999046
Lipocalin-2 Exacerbates Lupus Nephritis by Promoting Th1 Cell Differentiation., PMID:32646856
A Method of Assessment of Human Natural Killer Cell Phenotype and Function in Whole Blood., PMID:32508837
Cloning and Expression of the Tibetan Pig Interleukin-23 Gene and Its Promotion of Immunity of Pigs to PCV2 Vaccine., PMID:32466622
STAT4 sequence variant and elevated gene expression are associated with type 1 diabetes in Polish children., PMID:32425676
Intracerebral Hemorrhage Induced Brain Injury Is Mediated by the Interleukin-12 Receptor in Rats., PMID:32308392
Immunological Fingerprints of Controllers Developing Neutralizing HIV-1 Antibodies., PMID:31995767
Genetics of Antiphospholipid Syndrome., PMID:31807905
The IL-12-STAT4 axis in the pathogenesis of human systemic lupus erythematosus., PMID:31762023
IL-12 signaling drives the differentiation and function of a TH1-derived TFH1-like cell population., PMID:31570752
Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses., PMID:31456798
For research use only. Not for human or drug use.
