Catalog No.
RHG84701
Species reactivity
Human, Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:100, WB: 1:500-1:1000
Target
HHG-2, IHH, Indian hedgehog protein
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q14623
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2F59
Effect of FcRn Binding on Monoclonal Antibody Disposition in the Brain., PMID:40169451
Safety and efficacy of ruxolitinib cream for the treatment of vitiligo: A randomised controlled trial secondary analysis at 3 years., PMID:39624731
Hedgehog Signaling Controls Chondrogenesis and Ectopic Bone Formation via the Yap-Ihh Axis., PMID:38540766
Exploring the natural and treatment history of vitiligo: perceptions of patients and healthcare professionals from the global VALIANT study., PMID:37493275
Cytotoxicity of the CD3×CD20 bispecific antibody epcoritamab in CLL is increased by concurrent BTK or BCL-2 targeting., PMID:37219524
Generation of an Ihh-mKate2-Dre knock-in mouse line., PMID:35765931
Association of sonic hedgehog signaling pathway genes IHH, BOC, RAB23a and MIR195-5p, MIR509-3-5p, MIR6738-3p with gastric cancer stage., PMID:33811245
Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment., PMID:33777671
New insights into the GDF9-Hedgehog-GLI signaling pathway in human ovaries: from fetus to postmenopause., PMID:33772413
Epcoritamab induces potent anti-tumor activity against malignant B-cells from patients with DLBCL, FL and MCL, irrespective of prior CD20 monoclonal antibody treatment., PMID:33602901
Local injections of β-NGF accelerates endochondral fracture repair by promoting cartilage to bone conversion., PMID:33335129
FosB recruits KAT5 to potentiate the growth and metastasis of papillary thyroid cancer in a DPP4-dependent manner., PMID:32891613
SEMA3A and IGSF10 Are Novel Contributors to Combined Pituitary Hormone Deficiency (CPHD)., PMID:32612575
Runx1 up-regulates chondrocyte to osteoblast lineage commitment and promotes bone formation by enhancing both chondrogenesis and osteogenesis., PMID:32391876
Angiogenic Potential of Tissue Engineered Cartilage From Human Mesenchymal Stem Cells Is Modulated by Indian Hedgehog and Serpin E1., PMID:32363188
MiR-132/212 promotes the growth of precartilaginous stem cells (PCSCs) by regulating Ihh/PTHrP signaling pathway., PMID:32319512
Stromal Hedgehog pathway activation by IHH suppresses lung adenocarcinoma growth and metastasis by limiting reactive oxygen species., PMID:32108165
Preclinical and Clinical Development of ABBV-8E12, a Humanized Anti-Tau Antibody, for Treatment of Alzheimer's Disease and Other Tauopathies., PMID:29181488
Epiphyseal bone formation occurs via thyroid hormone regulation of chondrocyte to osteoblast transdifferentiation., PMID:28874841
Association of expression of the hedgehog signal with Merkel cell polyomavirus infection and prognosis of Merkel cell carcinoma., PMID:28551328
Requirement of Gαq/Gα11 Signaling in the Preservation of Mouse Intestinal Epithelial Homeostasis., PMID:28174748
Hedgehog pathway mediates early acceleration of liver regeneration induced by a novel two-staged hepatectomy in mice., PMID:27771454
The spleen contributes importantly to myocardial infarct exacerbation during post-ischemic reperfusion in mice via signaling between cardiac HMGB1 and splenic RAGE., PMID:27645145
Generation of a Bone Organ by Human Adipose-Derived Stromal Cells Through Endochondral Ossification., PMID:27334490
Expression and clinical significance of tyrosine phosphatase SHP2 in thyroid carcinoma., PMID:26622699
Efficient Detection of Indian Hedgehog During Endochondral Ossification by Whole-Mount Immunofluorescence., PMID:26179047
Anti-TNFα treatment decreases the previously increased serum Indian Hedgehog levels in patients with ankylosing spondylitis and affects the expression of functional Hedgehog pathway target genes., PMID:25701499
The novel small leucine-rich protein chondroadherin-like (CHADL) is expressed in cartilage and modulates chondrocyte differentiation., PMID:25451920
ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal adenocarcinoma: identification of novel targets for concerted therapy concepts., PMID:25435423
Hypoxia-hyperoxia paradigms in the development of oxygen-induced retinopathy in a rat pup model., PMID:25104123
The growth plate's response to load is partially mediated by mechano-sensing via the chondrocytic primary cilium., PMID:25084815
Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling., PMID:24344235
Ihh and Runx2/Runx3 signaling interact to coordinate early chondrogenesis: a mouse model., PMID:23383321
Tumor-stroma interaction in orthotopic primary pancreatic cancer xenografts during hedgehog pathway inhibition., PMID:23280784
Comparative functional analysis of two fibroblast growth factor receptor 1 (FGFR1) mutations affecting the same residue (R254W and R254Q) in isolated hypogonadotropic hypogonadism (IHH)., PMID:23276709
FGF23 suppresses chondrocyte proliferation in the presence of soluble α-Klotho both in vitro and in vivo., PMID:23235154
Autocrine Sonic hedgehog attenuates inflammation in cerulein-induced acute pancreatitis in mice via upregulation of IL-10., PMID:22956998
N-terminal region of gelsolin induces apoptosis of activated hepatic stellate cells by a caspase-dependent mechanism., PMID:22952982
Regulators of skeletal development: a cluster analysis of 206 bone tumors reveals diagnostically useful markers., PMID:22766796
Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh., PMID:22190639
Clinical features and testicular morphology in patients with Kallmann syndrome., PMID:22173178
Mutagenesis and analysis of genetic mutations in the GC-rich KISS1 receptor sequence identified in humans with reproductive disorders., PMID:21912371
Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu., PMID:21795282
Intercellular signaling pathways active during and after growth and differentiation of the lumbar vertebral growth plate., PMID:21245780
Ofd1 is required in limb bud patterning and endochondral bone development., PMID:20920500
Sox9 family members negatively regulate maturation and calcification of chondrocytes through up-regulation of parathyroid hormone-related protein., PMID:19759178
Expression of hedgehog signaling molecules in Merkel cell carcinoma., PMID:19644931
Signaling hierarchy regulating human endothelial cell development., PMID:19213939
The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla., PMID:18794898
Upregulation of Indian hedgehog gene in the uterine epithelium by leukemia inhibitory factor during mouse implantation., PMID:18239353
For research use only. Not for human or drug use.
