Catalog No.
RHG80301
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000
Target
Hairy homolog, Transcription factor HES-1, HRY, BHLHB39, Hairy-like protein, HES1, Class B basic helix-loop-helix protein 39, hHL, bHLHb39, Hairy and enhancer of split 1, HL
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q14469
Applications
FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2F45
Monocyte-lineage tumor infiltration predicts immunoradiotherapy response in advanced pretreated soft-tissue sarcoma: phase 2 trial results., PMID:40097400
Melatonin ameliorates astrogliosis and microgliosis in a cuprizone demyelinating mouse model., PMID:39926210
Disrupting Notch signaling related HES1 in myeloid cells reinvigorates antitumor T cell responses., PMID:39702544
Truncated recombinant Jagged1 fused with human IgG1 Fc activates Notch target genes in human periodontal ligament cells., PMID:39643955
Uncovering the mechanisms of host mitochondrial cardiolipin release in syphilis: Insights from human microvascular endothelial cells., PMID:38908301
Notch-1/2 receptors and Jagged-1 ligand, but not HERP-1 transcription factor, are immunohistochemically expressed in the epithelial lining of periapical cysts., PMID:38314334
Notch signaling regulates Th17 cells differentiation through PI3K/AKT/mTORC1 pathway and involves in the thyroid injury of autoimmune thyroiditis., PMID:38285310
NOTCH2 sensitizes the chondrocyte to the inflammatory response of tumor necrosis factor α., PMID:37865314
The beneficial effects of l-carnitine and infliximab in methotrexate-induced hepatotoxicity: Emphasis on Notch1/Hes-1 signaling., PMID:37625018
Anti-cerebral ischemic neuronal injury mechanism of Zhenlong Xingnao capsules: role of the Notch/NF-κB signaling pathway., PMID:37560215
Overexpression and potential roles of midkine via regulation of vascular endothelial growth factor A in psoriasis., PMID:37218430
LY294002 ameliorates psoriatic skin inflammation in mice via blocking the Notch1/Hes1-PTEN/AKT/IL-17A feedback loop., PMID:36840628
Endothelial Cell Markers Are Inferior to Vascular Smooth Muscle Cells Markers in Staining Vasa Vasorum and Are Non-Specific for Distinct Endothelial Cell Lineages in Clinical Samples., PMID:36768296
Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis., PMID:36535970
lncRNA MAFG‑AS1 enhances radioresistance of glioblastoma cells via miR‑642a‑5p/Notch1 axis., PMID:36214714
Anti-EGF nanobodies enhance the antitumoral effect of osimertinib and overcome resistance in non-small cell lung cancer (NSCLC) cellular models., PMID:36071367
Pancreatic-Like Cells Derived From Mouse Embryonic Stem Cells Are Regulated by Pdx1 Involving the Notch Pathway., PMID:35695761
Notch2 Blockade Mitigates Methotrexate Chemotherapy-Induced Bone Loss and Marrow Adiposity., PMID:35563828
Aniridia-related keratopathy relevant cell signaling pathways in human fetal corneas., PMID:35551459
Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis., PMID:35215234
Interleukine-17 Modulates Neurogenesis and Behavior Following Exposure to Trauma in Mice., PMID:35159158
IL-6 and IL-8, secreted by myofibroblasts in the tumor microenvironment, activate HES1 to expand the cancer stem cell population in early colorectal tumor., PMID:33544929
Hes1 overexpression leads to expansion of embryonic neural stem cell pool and stem cell reservoir in the postnatal brain., PMID:33531431
A computational guided, functional validation of a novel therapeutic antibody proposes Notch signaling as a clinical relevant and druggable target in glioma., PMID:33004830
A Review on Notch Signaling and Colorectal Cancer., PMID:32630477
Decreased NOTCH1 Activation Correlates with Response to Ibrutinib in Chronic Lymphocytic Leukemia., PMID:31578228
Tbx1 and Foxi3 genetically interact in the pharyngeal pouch endoderm in a mouse model for 22q11.2 deletion syndrome., PMID:31412026
The Hajdu Cheney mutation sensitizes mice to the osteolytic actions of tumor necrosis factor α., PMID:31371452
An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice., PMID:31188489
Elevated Kallikrein-binding protein in diabetes impairs wound healing through inducing macrophage M1 polarization., PMID:31182110
The Orphan Nuclear Receptor TLX Represses Hes1 Expression, Thereby Affecting NOTCH Signaling and Lineage Progression in the Adult SEZ., PMID:31178417
α2-HS Glycoprotein in Plasma Extracellular Vesicles Inhibits the Osteogenic Differentiation of Human Mesenchymal Stromal Cells In Vitro., PMID:30881463
The influence of adalimumab on the expression profile of mRNAs and miRNAs related to the IL-12 and IL-23 signal paths., PMID:30707475
M1-Polarized Macrophages Promote Self-Renewing Phenotype of Hepatic Progenitor Cells with Jagged1-Notch Signalling Involved: Relevance in Primary Sclerosing Cholangitis., PMID:30671485
Altered Signaling Pathways in Aniridia-Related Keratopathy., PMID:30480741
IL-4-dependent Jagged1 expression/processing is associated with survival of chronic lymphocytic leukemia cells but not with Notch activation., PMID:30478302
Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each., PMID:30418981
Alterations of Notch pathway in patients with adenoid cystic carcinoma of the trachea and its impact on survival., PMID:29858025
The regulatory roles of Notch in osteocyte differentiation via the crosstalk with canonical Wnt pathways during the transition of osteoblasts to osteocytes., PMID:29331299
Crosstalk between TLR4 and Notch1 signaling in the IgA nephropathy during inflammatory response., PMID:29230705
Coculture of endothelial progenitor cells and mesenchymal stem cells enhanced their proliferation and angiogenesis through PDGF and Notch signaling., PMID:29123981
Production of proinflammatory mediators in activated microglia is synergistically regulated by Notch-1, glycogen synthase kinase (GSK-3β) and NF-κB/p65 signalling., PMID:29049420
Hematopoietic stem cell-derived exosomes promote hematopoietic differentiation of mouse embryonic stem cells in vitro via inhibiting the miR126/Notch1 pathway., PMID:29047461
The Hajdu Cheney Mutation Is a Determinant of B-Cell Allocation of the Splenic Marginal Zone., PMID:29037852
Myeloid Notch1 deficiency activates the RhoA/ROCK pathway and aggravates hepatocellular damage in mouse ischemic livers., PMID:29024000
Alcohol Feeding in Mice Promotes Colonic Hyperpermeability and Changes in Colonic Organoid Stem Cell Fate., PMID:28992396
A mutation in NOTCH1 ligand binding region detected in patients with oral squamous cell carcinoma reduces NOTCH1 oncogenic effect., PMID:28791383
MTA-induced Notch activation enhances the proliferation of human dental pulp cells by inhibiting autophagic flux., PMID:28667754
Activation of STAT3/HIF-1α/Hes-1 axis promotes trastuzumab resistance in HER2-overexpressing breast cancer cells via down-regulation of PTEN., PMID:28499822
HES1 promotes extracellular matrix protein expression and inhibits proliferation and migration in human trabecular meshwork cells under oxidative stress., PMID:28423527
For research use only. Not for human or drug use.
