Catalog No.
RHG80101
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:100-1:200, WB: 1:1000-1:2000
Target
GRB7, Growth factor receptor-bound protein 7, GRB7 adapter protein, Epidermal growth factor receptor GRB-7, B47
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q14451
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2F43
Characterization of HER2-Low Breast Tumors among a Cohort of Colombian Women., PMID:39335113
Detecting Human Epidermal Growth Factor Receptor 2 (HER2) Amplification: Proof of Concept of an Alternative Approach., PMID:37809181
Prognostic value of ALK overexpression and molecular abnormalities in high-grade serous ovarian carcinoma., PMID:37522200
Randomized, open-label, phase 2 study of andecaliximab plus nivolumab versus nivolumab alone in advanced gastric cancer identifies biomarkers associated with survival., PMID:34893523
GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma., PMID:32737994
Phase II Feasibility and Biomarker Study of Neoadjuvant Trastuzumab and Pertuzumab With Chemoradiotherapy for Resectable Human Epidermal Growth Factor Receptor 2-Positive Esophageal Adenocarcinoma: TRAP Study., PMID:31809243
Dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and survival in breast cancer: a retrospective analysis of protein and mRNA expression., PMID:31740718
Genomic characterization of HER2-positive breast cancer and response to neoadjuvant trastuzumab and chemotherapy-results from the ACOSOG Z1041 (Alliance) trial., PMID:28453704
An Integrative Analysis to Identify Driver Genes in Esophageal Squamous Cell Carcinoma., PMID:26465158
Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy., PMID:26429917
c-Abl modulates tumor cell sensitivity to antibody-dependent cellular cytotoxicity., PMID:25300860
Predicting degree of benefit from adjuvant trastuzumab in NSABP trial B-31., PMID:24262440
Potential biomarkers of long-term benefit from single-agent trastuzumab or lapatinib in HER2-positive metastatic breast cancer., PMID:24075779
"Omics" of HER2-positive breast cancer., PMID:23421906
The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells., PMID:23253899
Protein pathway activation mapping reveals molecular networks associated with antiestrogen resistance in breast cancer cell lines., PMID:22328489
Correlation between gene expression of IGF-1R pathway markers and cetuximab benefit in metastatic colorectal cancer., PMID:22294722
A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk., PMID:20628393
EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells., PMID:20622016
Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer., PMID:19717535
The cell migration protein Grb7 associates with transcriptional regulator FHL2 in a Grb7 phosphorylation-dependent manner., PMID:18853468
Combination treatment with Grb7 peptide and Doxorubicin or Trastuzumab (Herceptin) results in cooperative cell growth inhibition in breast cancer cells., PMID:17426702
PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins., PMID:16783873
Disease-specific proteins from rheumatoid arthritis patients., PMID:16778393
Lipid-protein interactions of growth factor receptor-bound protein 14 in insulin receptor signaling., PMID:16300394
PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins., PMID:15642358
ERBB2 amplifications in esophageal adenocarcinoma., PMID:15511476
NIK is a component of the EGF/heregulin receptor signaling complexes., PMID:12853971
Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f, a novel member of the immunoglobulin superfamily encoded in the MHC., PMID:12852788
Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette., PMID:11075810
Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family., PMID:10664463
Lack of MHC class I surface expression on neoplastic cells and poor activation of the secretory pathway of cytotoxic cells in oral squamous cell carcinomas., PMID:10555762
Granzyme B immunoreactivity in T/natural killer cell lymphomas., PMID:9409191
Cloning and characterization of GRB14, a novel member of the GRB7 gene family., PMID:8647858
For research use only. Not for human or drug use.
