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Anti-CTTN Antibody (R2F31)

Catalog #:   RHG76801 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: IF, IHC, IP, WB
Accession: Q14247
Overview

Catalog No.

RHG76801

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

IF: 1:50-1:200, IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000

Target

Src substrate cortactin, Oncogene EMS1, CTTN, Amplaxin, EMS1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q14247

Applications

IF, IHC, IP, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.

Clone ID

R2F31

Data Image
  • Immunofluorescence
    Immunocytochemistry analysis of Cortactin(green) in Hela using Cortactin antibody,and DAPI(blue)
  • Immunohistochemical
    Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Cortactin antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
  • Western blot
    Western blot analysis of Cortactin in K562, rat Brain, C6, 3T3, Hela lysates using Cortactin antibody.
References

Potential Biomarkers Associated with Prognosis and Trastuzumab Response in HER2+ Breast Cancer., PMID:37686651

A standardized extract of cultured Lentinula edodes mycelia downregulates cortactin in gemcitabine-resistant pancreatic cancer cells., PMID:34386076

Autoantibodies to cortactin and agrin in sera of patients with myasthenia gravis., PMID:33962172

[Not Available]., PMID:31082464

Optic Nerve Head Astrocytes Display Axon-Dependent and -Independent Reactivity in Response to Acutely Elevated Intraocular Pressure., PMID:30665231

Wnt5a causes ROR1 to complex and activate cortactin to enhance migration of chronic lymphocytic leukemia cells., PMID:30568170

TKS5-positive invadopodia-like structures in human tumor surgical specimens., PMID:30439350

Imatinib Alters Agonists-mediated Cytoskeletal Biomechanics in Lung Endothelium., PMID:29075042

Diagnostic utility of cortactin antibodies in myasthenia gravis., PMID:29068555

Fascin actin bundling controls podosome turnover and disassembly while cortactin is involved in podosome assembly by its SH3 domain in THP-1 macrophages and dendritic cells., PMID:25601713

Cortactin autoantibodies in myasthenia gravis., PMID:25193850

Identification of a novel myositis-associated antibody directed against cortactin., PMID:25182205

Serine phosphorylation of cortactin is required for maximal host cell invasion by Campylobacter jejuni., PMID:24188565

SRChing for the substrates of Src., PMID:24121272

Stabilization of actin bundles by a dynamin 1/cortactin ring complex is necessary for growth cone filopodia., PMID:23467367

Cortactin controls surface expression of the voltage-gated potassium channel K(V)10.1., PMID:23144454

Tyrosine phosphorylation of DEP-1/CD148 as a mechanism controlling Src kinase activation, endothelial cell permeability, invasion, and capillary formation., PMID:22898603

β₁Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy., PMID:22378044

Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells., PMID:22282019

Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways., PMID:21478254

Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence., PMID:21079800

Regulation of sealing ring formation by L-plastin and cortactin in osteoclasts., PMID:20650888

Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels., PMID:20542878

Cortactin gene amplification and expression in breast cancer: a chromogenic in situ hybridisation and immunohistochemical study., PMID:20213079

Localization of cortactin is associated with colorectal cancer development., PMID:19885549

Disruption of the cytoskeleton during Semaphorin 3A induced growth cone collapse correlates with differences in actin organization and associated binding proteins., PMID:19513995

Overexpression of cortactin in head and neck squamous cell carcinomas can be uncoupled from augmented EGF receptor expression., PMID:18607838

Aberrant expression of cortactin and fascin are effective markers for pathogenesis, invasion, metastasis and prognosis of gastric carcinomas., PMID:18575752

CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin., PMID:17702746

Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport., PMID:15821732

p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: role in NAD(P)H oxidase regulation by angiotensin II., PMID:15618548

Alteration of podocytes in a murine model of crescentic glomerulonephritis., PMID:15258770

RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery., PMID:14742709

Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton., PMID:12925758

Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src., PMID:12851885

Changes in cytoskeletal and tight junctional proteins correlate with decreased permeability induced by dexamethasone in cultured rat brain endothelial cells., PMID:12782340

A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton., PMID:12672817

Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis., PMID:12612086

Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin., PMID:12453877

The Src-cortactin pathway is required for clustering of E-selectin and ICAM-1 in endothelial cells., PMID:12060669

Primary arrest of circulating platelets on collagen involves phosphorylation of Syk, cortactin and focal adhesion kinase: studies under flow conditions., PMID:11988077

CD2AP and p130Cas localize to different F-actin structures in podocytes., PMID:11553524

Human cortactin as putative cancer antigen., PMID:11064458

Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape., PMID:11018064

An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradation., PMID:10442635

Characterization of the EMS1 gene and its product, human Cortactin., PMID:9823470

Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90., PMID:9813110

The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells., PMID:9748248

Cortactin localization in actin-containing adult and fetal tissues., PMID:9742075

Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER., PMID:9722593

Datasheet

Document Download

Anti-CTTN Antibody (R2F31).pdf

 

$ 290
Product specifications
50 μg 290 100 μg 484

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Anti-CTTN Antibody (R2F31) [RHG76801]
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