Catalog No.
RHG17001
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
WB: 1:1000-1:2000
Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4D, PDE43, PDE4D, DPDE3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q08499
Applications
WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2D27
Genetic polymorphisms to identify patients with an optimal response to tildrakizumab in psoriasis patients from real-life clinical practice., PMID:39081053
Next Generation PDE4 Inhibitors that Selectively Target PDE4B/D Subtypes: A Narrative Review., PMID:37924462
HIV vaccine candidate efficacy in female macaques mediated by cAMP-dependent efferocytosis and V2-specific ADCC., PMID:36732510
Subclinical thyroid disease and single nucleotide polymorphisms in reproductive-age women in areas of Shanxi Province, China, where iodine exposure is excessive., PMID:30485936
Cardiac fibroblast transcriptome analyses support a role for interferogenic, profibrotic, and inflammatory genes in anti-SSA/Ro-associated congenital heart block., PMID:28626076
Higher expression of TNFα-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapy., PMID:26792343
PI3K/AKT and Mdm2 activation are associated with inhibitory effect of cAMP increasing agents on DNA damage-induced cell death in human pre-B NALM-6 cells., PMID:25524737
Effects of PDE4 pathway inhibition in rat experimental stroke., PMID:25224348
Defining the phosphodiesterase superfamily members in rat brain microvessels., PMID:22860158
PRKAR1A mutation affecting cAMP-mediated G protein-coupled receptor signaling in a patient with acrodysostosis and hormone resistance., PMID:22723333
Identification of new signaling components in the sensory epithelium of human saccule., PMID:21886636
Cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase is functional in bovine mammary gland., PMID:19620657
The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release., PMID:19371330
AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa., PMID:16177223
Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue., PMID:15717866
Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey., PMID:11716814
Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects., PMID:11429397
Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase., PMID:11134006
Activation of the cAMP-specific phosphodiesterase PDE4D3 by phosphorylation. Identification and function of an inhibitory domain., PMID:10391907
Type 4 cyclic adenosine monophosphate-specific phosphodiesterases are expressed in discrete subcellular compartments during rat spermiogenesis., PMID:10218983
Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect., PMID:10213096
Subcellular localization of rolipram-sensitive, cAMP-specific phosphodiesterases. Differential targeting and activation of the splicing variants derived from the PDE4D gene., PMID:9677395
Characterization of the rolipram-sensitive, cyclic AMP-specific phosphodiesterases: identification and differential expression of immunologically distinct forms in the rat brain., PMID:9443929
Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B., PMID:8632354
Salbutamol up-regulates PDE4 activity and induces a heterologous desensitization of U937 cells to prostaglandin E2. Implications for the therapeutic use of beta-adrenoceptor agonists., PMID:7559525
Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3., PMID:7476886
Characterization of a hormone-inducible, high affinity adenosine 3'-5'-cyclic monophosphate phosphodiesterase from the rat Sertoli cell., PMID:7794911
For research use only. Not for human or drug use.
