Catalog No.
RHG14301
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IHC: 1:50-1:100, WB: 1:500-1:1000
Target
Splicing factor, arginine/serine-rich 1, ASF, ASF-1, Serine/arginine-rich splicing factor 1, SF2P33, SFRS1, SRSF1, SF2, Alternative-splicing factor 1, pre-mRNA-splicing factor SF2, P33 subunit
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q07955
Applications
IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2D18
[Not Available]., PMID:39287342
Targeting alternative splicing as a new cancer immunotherapy-phosphorylation of serine arginine-rich splicing factor (SRSF1) by SR protein kinase 1 (SRPK1) regulates alternative splicing of PD1 to generate a soluble antagonistic isoform that prevents T cell exhaustion., PMID:37973660
Estradiol in Systemic Lupus Erythematosus., PMID:37908893
SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps., PMID:36458014
SRSF1 promotes ASMC proliferation in asthma by competitively binding CCND2 with miRNA-135a., PMID:36280202
Immunohistochemical Expression of Serine and Arginine-Rich Splicing Factor 1 (SRSF1) in Fluoro-Edenite-Induced Malignant Mesothelioma: A Preliminary Study., PMID:34207798
Extracellular matrix stiffness controls VEGF165 secretion and neuroblastoma angiogenesis via the YAP/RUNX2/SRSF1 axis., PMID:34170441
Cleaved PGAM5 dephosphorylates nuclear serine/arginine-rich proteins during mitophagy., PMID:33872670
The Long Linker Region of Telomere-Binding Protein TRF2 Is Responsible for Interactions with Lamins., PMID:33804854
The splicing factor SRSF1 stabilizes the mRNA of TSLP to enhance acute lung injury., PMID:33607522
Unfolding the Role of Splicing Factors and RNA Debranching in AID Mediated Antibody Diversification., PMID:32924658
SRSF1-3, a splicing and somatic hypermutation regulator, controls transcription of IgV genes via chromatin regulators SATB2, UBN1 and histone variant H3.3., PMID:31986311
Early reduction of the splicing factor2/alternative splicing factor: a cellular inhibitor of the JC polyomavirus in natalizumab-treated MS patients long before developing progressive multifocal leukoencephalopathy., PMID:31468472
RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage., PMID:29742442
SRSF1-3 contributes to diversification of the immunoglobulin variable region gene by promoting accumulation of AID in the nucleus., PMID:28235482
Targeting the pro-angiogenic forms of VEGF or inhibiting their expression as anti-cancer strategies., PMID:27999187
Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice., PMID:27916986
JC polyomavirus expression and bell-shaped regulation of its SF2/ASF suppressor during the follow-up of multiple sclerosis patients treated with natalizumab., PMID:27812788
The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic pain., PMID:27616424
Pur-Alpha Induces JCV Gene Expression and Viral Replication by Suppressing SRSF1 in Glial Cells., PMID:27257867
Heterogeneous Nuclear Ribonucleoprotein C Proteins Interact with the Human Papillomavirus Type 16 (HPV16) Early 3'-Untranslated Region and Alleviate Suppression of HPV16 Late L1 mRNA Splicing., PMID:25878250
Aberrant proteomic expression of NSRP70 and its clinical implications and connection to the transcriptional level in adult acute leukemia., PMID:25176346
Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells., PMID:24550521
Identification of developmental competence-related genes in mature porcine oocytes., PMID:21774025
For research use only. Not for human or drug use.
