Catalog No.
RHG05801
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
WB: 1:1000-1:2000
Target
Ribonuclease L, Ribonuclease 4, 2-5A-dependent RNase, 2-5A-dependent ribonuclease, RNS4, RNASEL, RNase L
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q05823
Applications
WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2C75
Unraveling the Role of RNase L Knockout in Alleviating Immune Response Activation in Mice Bone Marrow after Irradiation., PMID:38473966
Reducing cell intrinsic immunity to mRNA vaccine alters adaptive immune responses in mice., PMID:37876532
Simultaneous Onset of Pediatric Systemic Lupus Erythematosus in Twin Brothers: Case Report., PMID:35783307
A specific promoter-type in ribonuclease L gene is associated with phagocytic activity in pigs., PMID:34321379
Activation of an Effective Immune Response after Yellow Fever Vaccination Is Associated with the Genetic Background and Early Response of IFN-γ and CLEC5A., PMID:33445752
OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug., PMID:30814222
Human β-defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen-specific immunity., PMID:30089512
A link between adipogenesis and innate immunity: RNase-L promotes 3T3-L1 adipogenesis by destabilizing Pref-1 mRNA., PMID:27831565
Opposing Roles of Double-Stranded RNA Effector Pathways and Viral Defense Proteins Revealed with CRISPR-Cas9 Knockout Cell Lines and Vaccinia Virus Mutants., PMID:27334583
Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon., PMID:26739051
Role of ribonuclease L in viral pathogen-associated molecular pattern/influenza virus and cigarette smoke-induced inflammation and remodeling., PMID:23913960
Lopinavir up-regulates expression of the antiviral protein ribonuclease L in human papillomavirus-positive cervical carcinoma cells., PMID:21685539
No association of xenotropic murine leukemia virus-related viruses with prostate cancer., PMID:21573232
No evidence of XMRV in prostate cancer cohorts in the Midwestern United States., PMID:21447170
XMRV infection in patients with prostate cancer: novel serologic assay and correlation with PCR and FISH., PMID:20371060
Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients., PMID:19835577
RNase L mediated protection from virus induced demyelination., PMID:19798426
[Anti-HIV effects of IFN-tau in human macrophages: role of cellular antiviral factors and interleukin-6]., PMID:18842358
The 2',5'-oligoadenylate synthetase 1b is a potent inhibitor of West Nile virus replication inside infected cells., PMID:16371364
Synthesis of novel siRNAs having thymidine dimers consisting of a carbamate or a urea linkage at their 3' overhang regions and their ability to suppress human RNase L protein expression., PMID:15823566
Proteasome-mediated degradation of RNase L in response to phorbol-12-myristate-13-acetate (PMA) treatment of mouse L929 cells., PMID:14585196
The quest for an efficacious antiviral for respiratory syncytial virus., PMID:12718405
Short interfering RNA confers intracellular antiviral immunity in human cells., PMID:12087357
Identification of a host protein essential for assembly of immature HIV-1 capsids., PMID:11780123
RNase L-independent specific 28S rRNA cleavage in murine coronavirus-infected cells., PMID:10982321
Characterization of RNABP, an RNA binding protein that associates with RNase L., PMID:10926206
Evidence for IRF-1-dependent gene expression deficiency in interferon unresponsive HepG2 cells., PMID:10446388
RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus-(EMCV)-infected cells., PMID:9660177
Lack of 2',5'-oligoadenylate-dependent RNase expression in the human hepatoma cell line HepG2., PMID:9561800
Biochemical evidence for a novel low molecular weight 2-5A-dependent RNase L in chronic fatigue syndrome., PMID:9243369
Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway., PMID:7539425
2-5A-dependent RNase molecules dimerize during activation by 2-5A., PMID:7876164
2',5'-Oligoadenylate-dependent RNase L is a dimer of regulatory and catalytic subunits., PMID:8463302
Polyclonal antibodies against RNase L. Subcellular localization of this enzyme in mouse cells., PMID:1706339
Cordycepin analogues of 2',5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase., PMID:1705437
The epidermal growth factor- and interferon-independent effects of double-stranded RNA in A431 cells., PMID:2459591
A (2'-5')An-dependent endonuclease: tissue distribution in BALB/c mice and the effects of IFN-beta treatment and anti-IFN-alpha/beta immunoglobulin on the levels of the enzyme., PMID:3171245
The synergistic cytocidal effect produced by immune interferon and tumor necrosis factor in HT-29 cells is associated with inhibition of rRNA processing and (2',5') oligo (A) activation of RNase L., PMID:2451518
Antiviral activity in L1210 cells of liposome-encapsulated (2'-5')oligo(adenylate) analogues., PMID:2992962
Independent regulation of ppp(A2'p)nA-dependent RNase in NIH 3T3, clone 1 cells by growth arrest and interferon treatment., PMID:4019482
Expression of the 2-5A system during the cell cycle., PMID:4029267
Polyclonal antibody directed against 2-5A-dependent RNase., PMID:2421296
For research use only. Not for human or drug use.
