Catalog No.
YHC82301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu236-Gln472
Predicted molecular weight
29.17 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P10635
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Debrisoquine 4-hydroxylase, CYP2DL1, Cytochrome P450 2D6, Cytochrome P450-DB1, CYPIID6, Cholesterol 25-hydroxylase, CYP2D6
Profiling the Tox21 Compound Library for Their Inhibitory Effects on Cytochrome P450 Enzymes., PMID:40507787
Drug-drug interactions between epidermal growth factor receptor tyrosine kinase inhibitors and rivaroxaban in vitro and in vivo., PMID:40460109
Association of initiating CYP2D6-metabolized opioids with risks of adverse outcomes in older adults receiving antidepressants: A retrospective cohort study., PMID:40455735
Clinical and pharmacogenomic predictors of survival in tamoxifen treated breast cancer female patients: a real-world study., PMID:40452016
Solanidine-derived CYP2D6 phenotyping elucidates phenoconversion in multimedicated geriatric patients., PMID:40441673
Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes., PMID:40437642
Analysis of CYP2D6 Gene Variant Frequencies in Iranian Population., PMID:40433186
The Immature Infant Liver: Cytochrome P450 Enzymes and their Relevance to Vaccine Safety and SIDS Research., PMID:40386062
[Study on the association between CYP2D6*10 polymorphism and adverse reactions to Tamoxifen]., PMID:40375591
Genetic variants in tamoxifen metabolism and early treatment discontinuation among premenopausal breast cancer patients., PMID:40369345
Mono-CYP CHO Model: A Recombinant Chinese Hamster Ovary Cell Platform for Investigating CYP-Specific Tamoxifen Metabolism., PMID:40362231
Cytochrome P450 2D6 Poor Metabolizers and Risperidone Treatment Failure: A 1-Year Longitudinal Study., PMID:40350722
Frequency and Implications of High-Risk Pharmacogenomic Phenotypes Identified in a Diverse Australian Pediatric Oncology Cohort., PMID:40347484
New nicotinamide-thiadiazol hybrids as VEGFR-2 inhibitors for breast cancer therapy: design, synthesis and in silico and in vitro evaluation., PMID:40337008
Pharmacogenetic pilot study of CYP2D6 and CYP1A2 genes in Italian patients with non-dystrophic myotonia and myotonic dystrophy treated with mexiletine., PMID:40324568
Impact of CYP2D6, MAOA, and UGT2B7 genetic variants on recurrence of Plasmodium Vivax in the Brazilian Amazon., PMID:40316617
Pyriproxyfen Disrupts the Ongoing Spermatogenesis Wave in Danio rerio Potentially Mediated by Voltage-Dependent Calcium Channels and Protein Kinase C., PMID:40308215
Antioxidant, Anti-Inflammatory, and Oral Bioavailability of Novel Sulfonamide Derivatives of Gallic Acid., PMID:40298632
Pharmacometabolomics Detects Various Unreported Metoprolol Metabolites in Urine of (Potential) Living Kidney Donors and Kidney Transplant Recipients., PMID:40285825
Assessment of CYP2D6 gene expression in liver tissue: Variability in CYP2D6 mRNA levels within genotype-predicted metabolizer phenotype groups., PMID:40280382
Xenobiotic metabolizing gene variants and the risk of male infertility - A systematic review, meta-analysis and in silico analysis., PMID:40271533
Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account., PMID:40261922
Phenoconversion of CYP3A4, CYP2C19 and CYP2D6 in Pediatrics, Adolescents and Young Adults With Lymphoma: Rationale and Design of the PEGASUS Study., PMID:40259519
Cisplatin-induced acute kidney injury increased brain 5-hydroxytryptamine levels partly due to the hippuric acid-induced upregulation of CYP2D4 expression and function in the brain of rats., PMID:40245581
The strong clinical interaction between bupropion and CYP2D6 is primarily mediated through bupropion metabolites and their stereoisomers: A paradigm for evaluating metabolites in drug-drug interaction risk., PMID:40245579
Revealing Pharmacokinetic Interactions of Tramadol, Tapentadol, and Venlafaxine: A Cutting-Edge Liquid Chromatography-Tandem Mass Spectrometry Analytical Approach in Rat Plasma., PMID:40242577
Species differences in microsomal metabolism of hydroxychloroquine., PMID:40233867
Sex and age effects on prevalence of CYP2C19 and CYP2D6 Phenoconversion risk over time in patients with psychosis., PMID:40228694
Evaluation of small interfering RNA-dependent knockdowns of drug-metabolizing enzymes in multiwell array culture of primary human hepatocyte spheroids for estimation of fraction metabolized., PMID:40220706
Validation studies and multiomics analysis of Zhx2 as a candidate quantitative trait gene underlying brain oxycodone metabolite (oxymorphone) levels and behavior., PMID:40215834
Using Big Data to Uncover Drug-Gene Interaction in Patients with Prostate Cancer., PMID:40200460
In vitro-in vivo scaling of cytochrome P450-mediated metabolic clearance using a relative activity factor approach., PMID:40199158
Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part I: A Review of the Pharmacokinetic Literature and Proposed Changes., PMID:40198781
Advancing inclusive healthcare through PBPK modelling: predicting the impact of CYP genotypes and enzyme ontogenies on infant exposures of venlafaxine and its active metabolite O-desmethylvenlafaxine in lactation., PMID:40185984
Application of cytochrome P450 enzyme assays to predict p53 inducers and AChE inhibitors that require metabolic activation., PMID:40180188
Pharmacogenomic Testing in the Clinical Laboratory: Historical Progress and Future Opportunities., PMID:40170583
Possible Drug-Drug Interactions Between Mesalamine and Tricyclic Antidepressants Through CYP2D6 Metabolism - In silico and In vitro Analyses., PMID:40169140
ADME profile of AP-238 - opioid designer drug (CAS: 140924-11-4): first application of multi-in silico approach methodology for comprehensive prediction of ADME profile (absorption, distribution, metabolism and excretion) important for clinical toxicology and forensic purposes., PMID:40154936
Toxicological insights into graphene family materials: Cytochrome P450 modulation and cellular stress in liver cells., PMID:40138895
Hepatic Impairment and the Differential Effects on Drug Clearance Mechanisms: Analysis of Pharmacokinetic Changes in Disease State., PMID:40136001
Influence of CYP2D6 phenotype on adherence, adverse effects, and attitudes in aripiprazole and risperidone users., PMID:40130908
Liver microsomal protein content and activity in patients with hepatocellular carcinoma and cirrhosis: implications for the in vivo prediction of individual hepatic clearance., PMID:40115928
Reinterpretation of pharmacogenomic phenotypes after combinatorial psychiatric testing., PMID:40109143
The Impact of CYP2D6 metabolizer phenotypes on the EDDP/methadone metabolic ratio: A comprehensive analysis., PMID:40080971
Valproic acid levels in neurodevelopmental disorders: correlation with CYP and SULT genes using LC-MS/MS., PMID:40055599
Mechanism of action of aloperine in the treatment of pulmonary arterial hypertension based on network pharmacology and molecular docking methods., PMID:40055190
CYP2D6 polymorphisms and endoxifen concentration in Chinese patients with breast cancer., PMID:40050768
Predictors of clozapine concentration and psychiatric symptoms in patients with schizophrenia., PMID:40048458
CYP2D6 polymorphism rs1065852 significantly increases the risk of type 2 diabetes., PMID:40028882
Pharmacogenomics-Based Detection of Variants Involved in Pain, Anti-inflammatory and Immunomodulating Agents Pathways by Whole Exome Sequencing and Deep in Silico Investigations Revealed Novel Chemical Carcinogenesis and Cancer Risks., PMID:40026294
For research use only. Not for human or drug use.
