Catalog No.
RHF41401
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IP: 1:20, WB: 1:500-1:1000
Target
Ras-related protein Rap-1b, RAP1B, GTP-binding protein smg p21B
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P61224
Applications
IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2A04
miR-28-5p targeted Rap1b attenuates splenic inflammation infiltration in immune thrombocytopenia., PMID:40197264
H3K36 methyltransferase NSD1 is essential for normal B1 and B2 cell development and germinal center formation., PMID:36532012
Theileria equi RAP-1a and RAP-1b proteins contain immunoreactive epitopes and are suitable candidates for vaccine and diagnostics development., PMID:35318949
The proteomes of endometrial stromal cell-derived extracellular vesicles following a decidualizing stimulus define the cells' potential for decidualization success., PMID:34524461
Rap1 Is Essential for B-Cell Locomotion, Germinal Center Formation and Normal B-1a Cell Population., PMID:34140948
Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers., PMID:32795414
Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis., PMID:32539601
Two novel, putative mechanisms of action for citalopram-induced platelet inhibition., PMID:30420683
The Rap1-cofilin-1 pathway coordinates actin reorganization and MTOC polarization at the B cell immune synapse., PMID:28167682
RAP-1a is the main rhoptry-associated-protein-1 (RAP-1) recognized during infection with Babesia sp. BQ1 (Lintan) (B. motasi-like phylogenetic group), a pathogen of sheep in China., PMID:27890082
GABAB receptor promotes its own surface expression by recruiting a Rap1-dependent signaling cascade., PMID:25967549
Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B., PMID:25569036
The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth., PMID:24790104
Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation., PMID:23611601
A novel neutralization sensitive and subdominant RAP-1-related antigen (RRA) is expressed by Babesia bovis merozoites., PMID:21554842
Statins inhibit T-acute lymphoblastic leukemia cell adhesion and migration through Rap1b., PMID:21233409
Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration., PMID:19176753
Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity., PMID:18714009
Critical role of ADP interaction with P2Y12 receptor in the maintenance of alpha(IIb)beta3 activation: association with Rap1B activation., PMID:16706985
Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins., PMID:16213650
Thrombopoietin complements G(i)- but not G(q)-dependent pathways for integrin {alpha}(IIb){beta}(3) activation and platelet aggregation., PMID:15863506
The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity., PMID:15286792
Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin., PMID:15078882
High glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathway., PMID:12196513
Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton., PMID:11994301
Identification of up-regulated Ras-like GTPase, Rap1b, by suppression subtractive hybridization., PMID:11737587
Rap1B and Rap2B translocation to the cytoskeleton by von Willebrand factor involves FcgammaII receptor-mediated protein tyrosine phosphorylation., PMID:10224142
Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells., PMID:10085069
Expression and localization of RAP1 proteins during myogenic differentiation., PMID:8900487
Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V., PMID:8608228
Activation of brain B-Raf protein kinase by Rap1B small GTP-binding protein., PMID:8576107
Ultrastructural localization of the small GTP-binding protein Rap1 in human platelets and megakaryocytes., PMID:7803284
Association of Rap1a and Rap1b proteins with late endocytic/phagocytic compartments and Rap2a with the Golgi complex., PMID:7962206
Evidence for Rap1 in vascular smooth muscle cells. Regulation of their expression by platelet-derived growth factor BB., PMID:8143870
Correlated expression of the 97 kDa sarcoendoplasmic reticulum Ca(2+)-ATPase and Rap1B in platelets and various cell lines., PMID:8297341
Purification of a novel ras GTPase-activating protein from rat brain., PMID:8226805
Mutational analysis of the cAMP-dependent protein kinase-mediated phosphorylation site of Rap1b., PMID:8463283
Role of rap1B and p21ras GTPase-activating protein in the regulation of phospholipase C-gamma 1 in human platelets., PMID:1323853
Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells., PMID:1628649
Rap1A is a substrate for cyclic AMP-dependent protein kinase in human neutrophils., PMID:1908879
Association of the Ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex., PMID:1900364
RAP2B: a RAS-related GTP-binding protein from platelets., PMID:2118648
Rap1-B is phosphorylated by protein kinase A in intact human platelets., PMID:1696481
Tissue and subcellular distributions of the smg-21/rap1/Krev-1 proteins which are partly distinct from those of c-ras p21s., PMID:2111441
For research use only. Not for human or drug use.
