Catalog No.
YHC81001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asp211
Predicted molecular weight
25.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P10415
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Apoptosis regulator Bcl-2, BCL2
Effect of exosomes derived from induced and human adipose tissue-derived mesenchymal stem cells on human cancer cells., PMID:40501094
Oral Combined Probiotics Clostridium butyricum and Akkermansia muciniphila Inhibits the Progression of 4T1 Breast Cancer by Activating Bcl-2/Bax Pathway., PMID:40497373
Development of Dry Powder Inhaler formulation for site specific delivery of nanoconjugates loaded with Curcumin and BCL2 siRNA in Lung Cancer., PMID:40466858
Breaking Boundaries in Cancer Therapy: Harnessing Chromothripsis- Induced Mutations for Targeted BCL2 Protein Destabilization., PMID:40457970
Medicago sativa Extracts Enhance the Anticancer Efficacy of GEM in PANC-1 Cells through Apoptosis Induction and BAX/BCL-2/CASP3 Expression Modulation., PMID:40439381
Comparative Study of ERK1/2, Bcl2, and Sorcin with Clinicopathological Characteristics of Gastric carcinoma: Tubular Adenocarcinoma Vs Signet Ring Cell Carcinoma., PMID:40439369
Effects of venetoclax, a BCL2 inhibitor, in systemic chronic active Epstein-Barr virus disease., PMID:40425709
Ectopic expression of miR-34a/-328 sensitizes breast cancer stem cells to gamma rays/doxorubicin by BCL2/ABCG2 targeting., PMID:40402331
Design and in vitro evaluation of novel tetrazole derivatives of dianisidine as anticancer agents targeting Bcl-2 apoptosis regulator., PMID:40399589
Preclinical approach of two novel tetrahydroquinoline derivatives targeting GPER and Bcl-2 for anti-glioblastoma therapy., PMID:40399430
Multi-omics analysis reveals classic decoction alleviates ulcerative colitis by modulating tryptophan metabolism, gut microbiota homeostasis, and mitochondrial Bax/Bcl-2 pathways., PMID:40398245
Myoinositol improves sperm parameters in diabetic rats by reducing oxidative stress and regulating apoptosis-related genes., PMID:40397159
CREBBP inactivation sensitizes B cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition., PMID:40393984
Ammonia-induced testicular tissue damage: Apoptosis and autophagy pathways mediated by regulating Cyt C/Bcl-2 and p62/LC3B pathways., PMID:40381750
Anti-BCL2 therapy eliminates giant congenital melanocytic nevus by senolytic and immune induction., PMID:40374605
Nephroprotective effects of hesperidin on ifosfamide-induced acute nephrotoxicity in rats: Role of NF-κB/TNF-α/ IL-1β, p53/caspase-3/Bax/Bcl-2, and ATF6/IRE1/PERK/GRP78 signaling pathways., PMID:40373990
Augmenting the Anti-Leukemic Activity of the BCL-2 Inhibitor Venetoclax Through Its Transformation Into Polypharmacologic Dual BCL-2/HDAC1 and Dual BCL-2/HDAC6 Inhibitors., PMID:40370107
IRF4 contributes to chemoresistance in IGH::BCL2-positive diffuse large B-cell lymphomas by mediating BCL2-induced SOX9 expression., PMID:40356256
The investigation of apoptosis-related genes in periodontitis., PMID:40355964
Effects of Bcl-2 protein molecules and IκB kinase on the cell death of glioma cells: a study based on the chemical molecular extract of Erigeron breviscapus., PMID:40345283
Association Aamong Ppolymorphisms in the Aapoptosis-Rrelated NKX3-1, Caspase-3, Caspase-9, and BCL-2 Genes and Prostate Cancer Susceptibility From 9706 Cases and 12,567 Controls., PMID:40344485
BCL-2 mutant B7H6-CAR-T cells synergized with venetoclax for treating small cell lung cancer., PMID:40341023
Chronic lymphocytic leukemia: what clinical progress have we seen in the last five years?, PMID:40314223
Sonrotoclax (BGB-11417) synergistically amplifies the radiotherapy-elicited anti-tumor immune response., PMID:40311913
Deciphering the effects of bixin on pulmonary alveolar adenocarcinoma migration and proliferation via targeting BAX/BCL-2 and Cyclin D1., PMID:40301461
Reactive Bcl2-positive germinal centres in paediatric tonsils: expanding the spectrum of lymphoma mimickers in children and adolescents., PMID:40289261
Concurrent papillary thyroid carcinoma and incidental cervical lymph node indolent B cell non-Hodgkin lymphoma: clinicopathological features, outcomes, and potential relationships., PMID:40259407
Bcl-2 May Contribute to Evolution of Endometrial Hyperplasia, but It Isn't a Factor in Subsequent Carcinogenesis., PMID:40256590
Oridonin combined with cisplatin synergistically induces apoptosis by activating the NOXA-BCL2 axis in esophageal squamous cell carcinoma., PMID:40250733
Double Strike in Chronic Lymphocytic Leukemia-The Combination of BTK and BCL2 Inhibitors in Actual and Future Clinical Practice., PMID:40243993
Molecular Profile (Estrogen Receptor, Progesterone Receptor, Bcl-2 and Ki-67) of the Ectopic Endometrium in Patients with Endometriosis., PMID:40243611
The role of Bcl‑2 in controlling the transition between autophagy and apoptosis (Review)., PMID:40242969
The t(18;22)/IGL::BCL2 translocation defines a unique CLL subtype: association with early treatment initiation., PMID:40240735
Enhanced apoptosis in damaged laminar tissue of acute laminitis induced by oligofructose overload in dairy cows., PMID:40233496
Successful treatment of primary refractory DLBCL/HGBL - MYC/BCL2 transformed from FL using glofitamab: a case report., PMID:40230856
In-silico analysis of nsSNPs in BCL-2 family proteins: Implications for colorectal cancer pathogenesis and therapeutics., PMID:40207085
MIS18BP1 promotes bladder cancer cell proliferation and growth via inactivating P53 signaling pathway., PMID:40205244
Discovery of a novel BCL-2 inhibitor GW806742X for the treatment of TNBC., PMID:40199403
DYRK1A inhibition results in MYC and ERK activation rendering KMT2A-R acute lymphoblastic leukemia cells sensitive to BCL2 inhibition., PMID:40148558
Zanubrutinib plus R-CHOP improves the treatment effect of newly diagnosed diffuse large B cell lymphoma with double expression of MYC and BCL-2., PMID:40145086
A First-in-Class Dual Degrader of Bcl-2/Bcl-xL Reverses HIV Latency and Minimizes Ex Vivo Reservoirs from Patients., PMID:40141414
Synthesis and Biological Evaluation of Quercetagetin Derivatives as the Inhibitors of Mcl-1 and Bcl-2 Against Leukemia., PMID:40141366
Hsa_circ_0000231 Accelerates Cell Autophagy and Promotes Cell Proliferation and Invasion of Colorectal Cancer via miR-140-3p/Bcl-2 Axis., PMID:40135563
TET1 mitigates prenatal fluoride-induced cognition impairment by modulating Bcl2 DNA hydroxymethylation level., PMID:40133886
Protective effects of crocin against gentamicin-induced damage in rat testicular tissue: Modulating the levels of NF-κB/TLR-4 and Bax/Bcl-2/caspase-3 signaling pathways., PMID:40127811
The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy., PMID:40113751
Targeting RBM39 with Tasisulam enhances TRAIL-induced apoptosis through DR5 upregulation and Bcl-2 downregulation in renal cell carcinoma., PMID:40112928
Curcumin protects rat endplate chondrocytes against IL-1β-induced apoptosis via Bcl-2/Bax regulation., PMID:40106034
Chlorpyrifos Induces Apoptosis in Macrophages by Activating Both Intrinsic and Extrinsic Apoptotic Pathways., PMID:40105182
Prognostic outcomes of diffuse large B-cell lymphoma patients with myelocytomatosis oncogene (MYC) and B-cell lymphoma 2 (BCL2) co-expression., PMID:40097775
For research use only. Not for human or drug use.
