Catalog No.
YHC79001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile21-Arg246
Predicted molecular weight
27.69 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P10144
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Granzyme-B,Cathepsin G-like 1, Granzyme-2, GZMB, Fragmentin-2,grzmB, Human lymphocyte protein, HLP, CTLA-1, CGL1, CTSGL1, CSPB, Lymphocyte protease, T-cell serine protease 1-3E, Granzyme B, CTLA1, GRB, C11, Cytotoxic T-lymphocyte proteinase 2, SECT
SLC4A10 impedes atherosclerosis by diminishing IFN-γ/GZMB levels of CD8+ T cells via the MAPK pathway., PMID:40510365
Immune profiling of kidney transplant recipients: the role of Tribbles-1, Perforin, and Granzyme B in chronic humoral rejection., PMID:40488991
The functionality of telomerase depends on CPF-CF induced 3'end processing of its RNA component TLC1 and a novel Nrd1-Nab3 surveillance mechanism., PMID:40488281
In vivo proximity-labeling with miniTurboID to screen for protein-protein interactions in the filamentous ascomycete Sordaria macrospora., PMID:40488163
Glutamate transporter SLC1A6 promotes resistance to immunotherapy in cancer., PMID:40481876
Impact of immune checkpoint TIGIT on the activation and function of natural killer cells in rheumatoid arthritis patients., PMID:40465407
Evidence from a Comprehensive Bioinformatics Analysis Point to Possible Therapeutic Targets for Vitiligo., PMID:40452777
The Impact of Human Milk Oligosaccharides on Antibiotic-Induced Microbial Dysbiosis and Gut Inflammation in Mice., PMID:40426555
Myricetin-bound crystal structure of the SARS-CoV-2 helicase NSP13 facilitates the discovery of novel natural inhibitors., PMID:40421686
[Zfp335 regulates the proportion of effector Treg and tumor immunity]., PMID:40415616
CXCL8 and GZMB genes promote cartilaginous and synovial lesion formation via NF-κB and MAPK signaling pathways in Kaschin-Beck disease., PMID:40414318
Identification of Natural Killer Cell-Related Genes as Potential Diagnostic Biomarkers for Pediatric Sepsis., PMID:40411297
Small Extracellular Vesicle (sEV) Uptake from Lung Adenocarcinoma and Squamous Cell Carcinoma Alters T-Cell Cytokine Expression and Modulates Protein Profiles in sEV Biogenesis., PMID:40407494
IFT20 regulates TFEB-dependent lytic granule biogenesis in cytotoxic T lymphocytes by orchestrating the MPR-dependent transport of granzyme B., PMID:40389449
Engineering anti-BCMA CAR T cells for enhancing myeloma killing efficacy via apoptosis regulation., PMID:40389394
Inhibition of UCH-L1 enhances immunotherapy efficacy in triple-negative breast cancer by stabilizing PD-L1., PMID:40389130
Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B., PMID:40381623
Antioxidant interventions reduced cytokine-induced pyroptosis of peripheral MAIT cells in patients with HBV-related cirrhosis., PMID:40377492
The Human Bone Marrow May Offer an IL-15-Dependent Survival Niche for EOMES+ Tr1-Like Cells., PMID:40375822
Characterization of Two Stable Biodosimeters for Absorbed Ionizing Radiation Dose Estimation in Multiple Combined Injury Models., PMID:40360172
Rational development of gemcitabine-based nanoplatform for targeting SERPINB9/Granzyme B axis to overcome chemo-immune-resistance., PMID:40325025
Sonrotoclax (BGB-11417) synergistically amplifies the radiotherapy-elicited anti-tumor immune response., PMID:40311913
Novel diagnostic biomarker and immune profiling of GPR56+ B cell subsets in systemic lupus erythematosus., PMID:40311320
Identification and regulation of circulating tumor-TCR-matched cytotoxic CD4+ lymphocytes by KLRG1 in bladder cancer., PMID:40299576
Identification of INOSITOL PHOSPHORYLCERAMIDE SYNTHASE 2 (IPCS2) as a new rate-limiting component in Arabidopsis pathogen entry control., PMID:40298354
Smad4 loss identifies aggressive subtype with immunotherapy and anti-HER-2 treatment resistance in gastric cancer., PMID:40281303
GPX2 inhibition enhances antitumor efficacy of lenvatinib via promoting immunogenic cell death in hepatocellular carcinoma., PMID:40251668
Parabacteroides distasonis promotes CXCL9 secretion of tumor-associated macrophages and enhances CD8+T cell activity to trigger anti-tumor immunity against anti-PD-1 treatment in non-small cell lung cancer mice., PMID:40241108
Combination radiation and αPD-L1 enhance tumor control by stimulating CD8+ PD-1+ TCF-1+ T cells in the tumor-draining lymph node., PMID:40229241
Single cell transcriptome sequencing indicates the cellular heterogeneity of small intestine tissue in celiac disease., PMID:40216823
Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects., PMID:40216443
Identification of Salivary Biomarkers in Colorectal Cancer by Integrating Olink Proteomics and Metabolomics., PMID:40183281
Huaier enhances the antitumor effects of CDK 4/6 inhibitor by remodeling the immune microenvironment and gut microbiota in breast cancer., PMID:40179997
Reciprocal roles of two trehalose transporters in aestivating cabbage stem flea beetle (Psylliodes chrysocephala)., PMID:40174677
Attenuated Salmonella carrying IL-21 overexpression plasmid enhances radiotherapy efficacy in a preclinical model of melanoma., PMID:40174337
T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses., PMID:40169810
Targeting PD-1 and CD85j can restore intratumoral CD4+ GzmB+ T-cell functions to combat MHC-II-expressing tumors., PMID:40169283
Single cell multi-omics reveals re-dosing with CD3 bispecific antibody induces a TCF7 high central memory CD8 + T cell population associated with reduced cytokine production., PMID:40168725
Association of the characteristics of brain magnetic resonance imaging with genes related to disease onset in schizophrenia patients., PMID:40158807
Patient-specific mutation of contact site protein Tomm70 causes neurodegeneration., PMID:40151845
Microbiota-reprogrammed phosphatidylcholine inactivates cytotoxic CD8 T cells through UFMylation via exosomal SerpinB9 in multiple myeloma., PMID:40128181
Hafnium Metal-Organic Framework-Based Glutamine Metabolism Disruptor For Potentiating Radio-Immunotherapy in MYC-Amplified Hepatocellular Carcinoma., PMID:40116395
Microwave ablation combined with α-PD-L1 enhances abscopal effect and promotes CTL activation and intratumoral homing by a cytokine network involving IFN-γ and CXCL9., PMID:40101420
Granzyme B producing regulatory B-cells in patients with giant cell arteritis., PMID:40095634
Arabidopsis GH3.10 conjugates jasmonates., PMID:40095511
RFX2 downregulates RASSF1 expression and YAP phosphorylation through Hippo signaling to promote immune escape in lung adenocarcinoma., PMID:40069841
Structural basis of Nipah virus RNA synthesis., PMID:40050611
GPR132 regulates the function of NK cells through the Gαs/CSK/ZAP70/NF-κB signaling pathway as a potential immune checkpoint., PMID:40043109
USP19 deficiency enhances T-cell-mediated antitumor immunity by promoting PD-L1 degradation in colorectal cancer., PMID:40020887
The plastid-encoded RNA polymerase of plant chloroplasts., PMID:40011163
For research use only. Not for human or drug use.
