Catalog No.
YHC78001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met111-Ser343
Predicted molecular weight
27.83 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P10071
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GLI3 form of 190 kDa, GLI3FL, GLI3-83, Transcriptional activator GLI3, GLI3, GLI3-190, GLI3 C-terminally truncated form, GLI3 full-length protein, GLI3 form of 83 kDa
Two Nonsense GLI3 Variants Are Identified in Two Chinese Families With Polydactyly., PMID:40052367
An inherited predisposition allele promotes gastric cancer via enhancing deubiquitination-mediated activation of epithelial-to-mesenchymal transition signaling., PMID:39998882
PDE4 inhibitor rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer., PMID:39880092
Reduction of elevated Gli3 does not alter the progression of autosomal recessive polycystic kidney disease., PMID:39823139
Oncogenic potential of truncated-Gli3 via the Gsk3β/Gli3/AR-V7 axis in castration-resistant prostate cancer., PMID:39821099
Counterregulatory roles of GLI2 and GLI3 in osteogenic differentiation via Gli1 expression., PMID:39801296
Identification of Pappa and Sall3 as Gli3 direct target genes acting downstream of cilia signaling in corticogenesis., PMID:39716738
GLI3 Is Required for M2 Macrophage Polarization and M2-Mediated Waldenström Macroglobulinemia Growth and Survival., PMID:39684827
Distraction Enterogenesis Induces Desert Hedgehog in the Lengthened Murine Colon., PMID:39349347
miR-200c targeting GLI3 inhibits cell proliferation and promotes apoptosis in non-small cell lung cancer cells., PMID:39312343
Small molecule valproic acid enhances ventral patterning of human neural tube organoids by regulating Wnt and Shh signalling., PMID:39164046
Identification of truncated variants in GLI family zinc finger 3 (GLI3) associated with polydactyly., PMID:39080720
Hedgehog signaling pathway regulates Th17 cell differentiation in asthma via IL-6/STAT3 signaling., PMID:39074418
Construction and Identification of a Novel Mice Model of Microphthalmia., PMID:39007834
Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase., PMID:38968120
A novel missense variant located within the zinc finger domain of the GLI3 gene was identified in a Vietnamese pedigree with index finger polydactyly., PMID:38864382
Distinct expression patterns of Hedgehog signaling components in mouse gustatory system during postnatal tongue development and adult homeostasis., PMID:38848388
TBX3 is essential for establishment of the posterior boundary of anterior genes and upregulation of posterior genes together with HAND2 during the onset of limb bud development., PMID:38828908
A Pilot Immunohistochemical Study Identifies Hedgehog Pathway Expression in Sinonasal Adenocarcinoma., PMID:38731849
A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex., PMID:38713624
Variant characterisation and clinical profile in a large cohort of patients with Ellis-van Creveld syndrome and a family with Weyers acrofacial dysostosis., PMID:38531627
Positive correlation between the nuclear expression of GPER and pGLI3 in prostate cancer tissues from patients with different Gleason scores., PMID:38370352
The GLI code controls HNF1A levels during foregut differentiation., PMID:38270262
ATRX is a predictive marker for endocrinotherapy and chemotherapy resistance in HER2-/HR+ breast cancer through the regulation of the AR, GLI3 and GATA2 transcriptional network., PMID:38126976
Two Novel Frameshift Mutations in the GLI3 Gene Underlie Non-Syndromic Polydactyly in Chinese Families., PMID:37768332
[GLI3 processing in the primary cilia of muscle stem cells controls their quiescence state]., PMID:37094263
[Analysis of variant of GLI3 gene in a child featuring autosomal dominant Pallister-Hall syndrome]., PMID:36585009
Conclusion of diagnostic odysseys due to inversions disrupting GLI3 and FBN1., PMID:36411030
Inferring and perturbing cell fate regulomes in human brain organoids., PMID:36198796
Pallister-Hall syndrome, GLI3, and kidney malformation., PMID:36165461
A novel mechanism of regulation of the oncogenic transcription factor GLI3 by toll-like receptor signaling., PMID:35937499
The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis., PMID:35931079
The forelimbs of Alvarezsauroidea (Dinosauria: Theropoda): Insight from evolutionary teratology., PMID:35915891
A novel variant of GLI3, p.Asp1514Thrfs*5, is identified in a Chinese family affected by polydactyly., PMID:35546307
De Novo GLI3 Pathogenic Variants May Cause Hypotonia and a Range of Brain Malformations Without Skeletal Abnormalities., PMID:35436645
Two nonsense GLI3 variants are associated with polydactyly and syndactyly in two families by affecting the sonic hedgehog signaling pathway., PMID:35218158
GLI3 and androgen receptor are mutually dependent for their malignancy-promoting activity in ovarian and breast cancer cells., PMID:35134468
Zic5 stabilizes Gli3 via a non-transcriptional mechanism during retinal development., PMID:35108539
GLI3 Is Required for OLIG2+ Progeny Production in Adult Dorsal Neural Stem Cells., PMID:35053334
Molecular Etiology in Thumb Polydactyly in Mutated GLI3 Mouse Gene., PMID:34936293
HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly., PMID:34928956
Greig Cephalopolysyndactyly Contiguous Gene Syndrome: Case Report and Literature Review., PMID:34828280
The Shh/Gli3 gene regulatory network precedes the origin of paired fins and reveals the deep homology between distal fins and digits., PMID:34750251
GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer., PMID:34610962
Conserved and species-specific chromatin remodeling and regulatory dynamics during mouse and chicken limb bud development., PMID:34584102
Long non-coding RNA SLC2A1-AS1 induced by GLI3 promotes aerobic glycolysis and progression in esophageal squamous cell carcinoma by sponging miR-378a-3p to enhance Glut1 expression., PMID:34517880
GLI3 variants causing isolated polysyndactyly are not restricted to the protein's C-terminal third., PMID:34482537
Homozygous GLI3 variants observed in three unrelated patients presenting with syndromic polydactyly., PMID:34296525
Hedgehog gene expression patterns among intrinsic subtypes of breast cancer: Prognostic relevance., PMID:34022683
Coexpression of EphA10 and Gli3 promotes breast cancer cell proliferation, invasion and migration., PMID:33990369
For research use only. Not for human or drug use.
