Catalog No.
RHE48803
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IP: 1:20, WB: 1:500-1:1000
Target
SAPK kinase 2, PRKMK3, Dual specificity mitogen-activated protein kinase kinase 3, MAPKK 3, SAPKK-2, MAP2K3, SKK2, MAP kinase kinase 3, SAPKK2, MEK3, Stress-activated protein kinase kinase 2, MKK3, MAPK/ERK kinase 3, MEK 3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P46734
Applications
IF, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1W82
Pharmacogenomics of intravenous immunoglobulin response in Kawasaki disease., PMID:38259468
Peripheral blood mononuclear cell- transcriptome signatures of atopic dermatitis and prediction for the efficacy of dupilumab., PMID:37349237
Blockade of CD26 signaling inhibits human osteoclast development., PMID:24821427
Stem cell factor induces AP-1-dependent mast cell IL-6 production via MAPK kinase 3 activity., PMID:24453276
HDAC inhibition elicits myocardial protective effect through modulation of MKK3/Akt-1., PMID:23762381
Stress-activated kinase pathway alteration is a frequent event in bladder cancer., PMID:22154358
Decreased collagen-induced arthritis severity and adaptive immunity in MKK-6-deficient mice., PMID:21953132
Recent insights into diabetic renal injury from the db/db mouse model of type 2 diabetic nephropathy., PMID:21147843
ß-Elemene inhibits proliferation of human glioblastoma cells and causes cell-cycle G0/G1 arrest via mutually compensatory activation of MKK3 and MKK6., PMID:21132268
Mouse preimplantation embryo responses to culture medium osmolarity include increased expression of CCM2 and p38 MAPK activation., PMID:17214902
Inactivation of the Akt survival pathway during photoreceptor apoptosis in the retinal degeneration mouse., PMID:16565401
The volatile anesthetics halothane and isoflurane differentially modulate proinflammatory cytokine-induced p38 mitogen-activated protein kinase activation., PMID:15290420
p38 MAPK is a critical regulator of the constitutive and the beta4 integrin-regulated expression of IL-6 in human normal thymic epithelial cells., PMID:14579272
Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells., PMID:12637505
The sesquiterpene lactone parthenolide inhibits LPS- but not TNF-alpha-induced maturation of human monocyte-derived dendritic cells by inhibition of the p38 mitogen-activated protein kinase pathway., PMID:12170268
Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization., PMID:12149431
Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2., PMID:11279118
Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway., PMID:10842172
Cell cycle arrest and reversion of Ras-induced transformation by a conditionally activated form of mitogen-activated protein kinase kinase kinase 3., PMID:10207109
Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades., PMID:9841871
Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6., PMID:9430721
Expression, purification, and characterization of an activated cytokine-suppressive anti-inflammatory drug-binding protein 2 (CSBP2) kinase from baculovirus-infected insect cells., PMID:9226723
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3., PMID:8663074
Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase., PMID:8621389
For research use only. Not for human or drug use.
