Catalog No.
RHE38701
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Target
SLC1A2, Glutamate/aspartate transporter II, GLT1, EAAT2, Solute carrier family 1 member 2, Excitatory amino acid transporter 2, Sodium-dependent glutamate/aspartate transporter 2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P43004
Applications
IF, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1W36
Astrocytic c-Jun N-terminal kinase-histone deacetylase-2 cascade contributes to glutamate transporter-1 decrease and mechanical allodynia following peripheral nerve injury in rats., PMID:34333051
Neuron-Derived Estrogen Is Critical for Astrocyte Activation and Neuroprotection of the Ischemic Brain., PMID:32817249
Reciprocal communication between astrocytes and endothelial cells is required for astrocytic glutamate transporter 1 (GLT-1) expression., PMID:32650029
Imaging tripartite synapses using super-resolution microscopy., PMID:31153907
Specific Alterations in Astrocyte Properties via the GluA2-GAPDH Complex Associated with Multiple Sclerosis., PMID:30150703
SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions., PMID:28336567
Reduced responses to glutamate receptor agonists follow loss of astrocytes and astroglial glutamate markers in the nucleus tractus solitarii., PMID:28270593
Novel Applications of Magnetic Cell Sorting to Analyze Cell-Type Specific Gene and Protein Expression in the Central Nervous System., PMID:26919701
Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis., PMID:25434487
Thiamine deficiency results in release of soluble factors that disrupt mitochondrial membrane potential and downregulate the glutamate transporter splice-variant GLT-1b in cultured astrocytes., PMID:24735535
Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats., PMID:23714777
Amyloid-β-induced astrocytic phagocytosis is mediated by CD36, CD47 and RAGE., PMID:23238794
Overstimulation of NMDA receptors impairs early brain development in vivo., PMID:22606296
Specificity controls for immunocytochemistry: the antigen preadsorption test can lead to inaccurate assessment of antibody specificity., PMID:22215633
Evidence against cellular internalization in vivo of NMO-IgG, aquaporin-4, and excitatory amino acid transporter 2 in neuromyelitis optica., PMID:22069320
Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2., PMID:21769946
Differential regulation of C-terminal splice variants of the glutamate transporter GLT-1 by tumor necrosis factor-alpha in primary cultures of astrocytes., PMID:21371514
Glutamate clearance mechanisms in resected cortical dysplasia., PMID:21073256
The concentrations and distributions of three C-terminal variants of the GLT1 (EAAT2; slc1a2) glutamate transporter protein in rat brain tissue suggest differential regulation., PMID:19328838
Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2., PMID:18838545
A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2)., PMID:18805467
Expression of the exon 9-skipping form of EAAT2 in astrocytes of rats., PMID:17981401
Reactive astrocytes and activated microglial cells express EAAT1, but not EAAT2, reflecting a neuroprotective potential following ischaemia., PMID:17543080
TNFR1 mediates increased neuronal membrane EAAT3 expression after in vivo cerebral ischemic preconditioning., PMID:16442237
Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1., PMID:15927426
Expression of glutamate transporter subtypes during normal human corticogenesis and type II lissencephaly., PMID:15804404
In vitro ischemic tolerance involves upregulation of glutamate transport partly mediated by the TACE/ADAM17-tumor necrosis factor-alpha pathway., PMID:14960606
Neuronal glutamate transporter EAAT4 is expressed in astrocytes., PMID:12951653
Increased expression of the neuronal glutamate transporter (EAAT3/EAAC1) in hippocampal and neocortical epilepsy., PMID:11906504
Antisense knockdown of glutamate transporters alters the subfield selectivity of kainate-induced cell death in rat hippocampal slice cultures., PMID:10537040
Changes in expression of neuronal and glial glutamate transporters in rat hippocampus following kainate-induced seizure activity., PMID:10036313
Neuronal expression of the glutamate transporter GLT-1 in hippocampal microcultures., PMID:9614226
The glutamate transporter EAAT4 in rat cerebellar Purkinje cells: a glutamate-gated chloride channel concentrated near the synapse in parts of the dendritic membrane facing astroglia., PMID:9570792
Structural selectivity and molecular nature of L-glutamate transport in cultured human fibroblasts., PMID:9606970
For research use only. Not for human or drug use.
