Catalog No.
EHC43301
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Thr274
Predicted molecular weight
35.71 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P09758
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Pancreatic carcinoma marker protein GA733-1, Tumor-associated calcium signal transducer 2, M1S1, TROP2, TACSTD2, Cell surface glycoprotein Trop-2, GA733-1, Membrane component chromosome 1 surface marker 1
From biomarker to targeted therapy: investigating trophoblast cell-surface antigen 2 expression in triple-negative breast cancer- insights from the national cancer institute., PMID:40474193
Assessment of trophoblast cell-surface antigen 2 (TROP2) and nectin-4 expression in choriocarcinoma., PMID:40414312
Trop2, Nectin-4, and PD-L1 expression profiles in esophageal squamous cell carcinoma: Implications for combined immunotherapy and ADC targeted therapies., PMID:40403357
LBA and LC-MS/MS based comprehensive bioanalytical methods for FDA018, a Trop-2 targeted antibody-drug conjugate., PMID:40375398
Novel TROP2 antibody-drug conjugates for treatment of HER2-negative metastatic breast cancer patients with brain metastases: a promising option☆., PMID:40359710
Differential Localization of β-Catenin Protein in CTNNB1 Mutant Endometrial Cancers Results in Distinct Transcriptional Profiles., PMID:40348058
TROP2 expression and therapeutic targeting in uterine carcinosarcoma., PMID:40344963
Biomarkers of response to antibody-drug conjugates (TROP2 and nectin-4) and the immune microenvironment (NKG7, PD-L1, and B7-H3) in penile squamous cell carcinoma., PMID:40327767
Integrating analysis of multi-omics summary data identifies novel plasma protein biomarkers and drug targets for bladder cancer., PMID:40316856
Preclinical Activity of Datopotamab Deruxtecan, an Antibody-Drug Conjugate Targeting Trophoblast Cell-Surface Antigen 2, in Uterine Serous Carcinoma., PMID:40299780
Modular assembly and evaluation of a TROP2-targeting immunotoxin for cancer therapy., PMID:40253026
Trop-2 expression in non-small cell lung cancer., PMID:40233061
Trop2-expression in primary vulvar squamous cell carcinoma., PMID:40184712
[Preparation of Trop2-Targeted CAR-T Cells Based on Nanobodies and Their Antitumor Effects Against Non-Small Cell Lung Cancer]., PMID:40109477
Proteomic Changes Associated With Endogenous FBXW7 Mutations in Moderately Differentiated Endometrial Cancer Cells Include Increased TROP2 and Galectin-3 Levels., PMID:40087851
Preclinical evaluation of a novel antibody-drug conjugate OBI-992 for Cancer therapy., PMID:40082588
Prognostic Value of Trop-2 Expression in Nonmetastatic Triple-Negative Breast Cancer and Correlation With Emerging Biomarkers., PMID:40059728
ImmunoPET Imaging of Trop2 Expression in Bladder Cancer Using [64Cu]Cu-NOTA-Trodelvy., PMID:40059341
Noninvasive molecular imaging using anti-Trop-2 aptamer for targeted therapy of small cell lung cancer., PMID:40050871
Five-Gene Expression Signature Associated With Acquired FOLFIRI Resistance and Survival in Metastatic Colorectal Cancer., PMID:39954853
[99mTc]Tc-MY6349 Probe for Trop2-Targeted SPECT Imaging: From Preclinical to Pilot Clinical Study., PMID:39947911
The Mode of Action and Clinical Outcomes of Sacituzumab Govitecan in Solid Tumors., PMID:39903492
Targeting AXL Inhibits the Growth and Metastasis of Prostate Cancer in Bone., PMID:39879384
Preclinical evaluation of zirconium-89 labeled anti-Trop2 antibody-drug conjugate (Trodelvy) for imaging in gastric cancer and triple-negative breast cancer., PMID:39878898
Trop2 Expression in Correlation to the Molecular Subtype in Vulvar Squamous Cell Carcinomas., PMID:39837304
OBI-992, a Novel TROP2-Targeted Antibody-Drug Conjugate, Demonstrates Antitumor Activity in Multiple Cancer Models., PMID:39786401
Large, recursive membrane platforms are associated to Trop-1, Trop-2, and protein kinase signaling for cell growth., PMID:39785844
Metformin-encapsulating immunoliposomes conjugated with anti-TROP 2 antibody fragments for the active targeting of triple-negative breast cancer., PMID:39775761
A multicenter study on TROP2 as a potential targeted therapy for extramammary Paget disease in Japan., PMID:39747638
Trop-2 and Ephrin B2 expression in urothelial carcinoma with divergent differentiation and aggressive urothelial carcinoma subtypes., PMID:39705501
The Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) oncogene is upregulated in cystic epithelial cells revealing a potential new target for polycystic kidney disease., PMID:39666736
Sacituzumab Govitecan in Patients with Relapsed/Refractory Advanced Head and Neck Squamous Cell Carcinoma: Results from the Phase II TROPiCS-03 Basket Study., PMID:39665770
[Research Progress and Perspectives of Antibody-drug Conjugates Targeting
Trophoblast Cell Surface Antigen-2 in Advanced Non-small Cell Lung Cancer]., PMID:39631833
Antitumor Activity and Biomarker Analysis for TROP2 Antibody-Drug Conjugate Datopotamab Deruxtecan in Patient-Derived Breast Cancer Xenograft Models., PMID:39585341
An EpCAM/Trop2 mechanostat differentially regulates collective behaviour of human carcinoma cells., PMID:39572744
Evaluation of trophoblast cell surface antigen-2 (TROP2) protein expression in chemotherapy-resistant and metastatic breast carcinomas., PMID:39571340
Novel Amanitin-Based Antibody-Drug Conjugates Targeting TROP2 for the Treatment of Pancreatic Cancer., PMID:39564769
Advances in Trop-2 targeted antibody-drug conjugates for breast cancer: mechanisms, clinical applications, and future directions., PMID:39555080
Immuno-PET/CT Imaging of Trop2 with [18F]AlF-RESCA-T4 Differentiates Lung Cancer from Inflammation., PMID:39542697
Trop2-Targeted Molecular Imaging in Solid Tumors: Current Advances and Future Outlook., PMID:39537365
Current Status and Future Prospects of TROP-2 ADCs in Lung Cancer Treatment., PMID:39525044
68Ga-MY6349 PET/CT imaging to assess Trop2 expression in multiple types of cancer., PMID:39509246
Unveiling the future of breast cancer therapy: Cutting-edge antibody-drug conjugate strategies and clinical outcomes., PMID:39500221
Antibody-drug conjugates as targeted therapy for treating gynecologic cancers: update 2025., PMID:39480912
TROP2 Expression and Therapeutic Implications in Cutaneous Squamous Cell Carcinoma: Insights From Immunohistochemical and Functional Analysis., PMID:39422290
Modulating autophagy to boost the antitumor efficacy of TROP2-directed antibody-drug conjugate in pancreatic cancer., PMID:39418963
Intraoperative evaluation of tumor margins using a TROP2 near-infrared imaging probe to enable human breast-conserving surgery., PMID:39413161
Clinicopathologic Characteristics of Trop Family Proteins (Trop-2 and EpCAM) in Gastric Carcinoma., PMID:39375055
The genomic and transcriptomic landscape of metastastic urothelial cancer., PMID:39366934
Selection of trophoblast cell surface antigen 2-targeted aptamer for the development of cytotoxic aptamer-drug conjugate., PMID:39250993
For research use only. Not for human or drug use.
