Catalog No.
RHD99203
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
WB: 1:1000-1:2000
Target
MC4R, MC4-R, Melanocortin receptor 4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P32245
Applications
WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1U48
Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist., PMID:39353917
MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis., PMID:36175420
Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders., PMID:33960608
The complicated clinical course in a case of atypical lipodystrophy after development of neutralizing antibody to metreleptin: treatment with setmelanotide., PMID:32213649
Hypothalamic C2-domain protein involved in MC4R trafficking and control of energy balance., PMID:31666192
Immunoglobulin G modulation of the melanocortin 4 receptor signaling in obesity and eating disorders., PMID:30755592
From lipid locus to drug target through human genomics., PMID:29800275
Activity of the Hypothalamic Melanocortin System Decreases in Middle-Aged and Increases in Old Rats., PMID:29099963
Melanocortin receptor subtypes are expressed on cells in the oligodendroglial lineage and signal ACTH protection., PMID:28877366
Melanocortin 2, 3 and 4 Receptor Gene Expressions are Downregulated in CD8+ T Cytotoxic Lymphocytes and CD19+ B Lymphocytes in Rheumatoid Arthritis Responding to TNF-α Inhibition., PMID:28426141
Association of adenovirus 36 infection with obesity-related gene variants in adolescents., PMID:26680480
Nesfatin-1 Suppresses Cardiac L-type Ca²⁺ Channels Through Melanocortin Type 4 Receptor and the Novel Protein Kinase C Theta Isoform Pathway., PMID:25997563
Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms., PMID:25427253
Leptin receptor signaling inhibits ovarian follicle development and egg laying in chicken hens., PMID:24650216
Alpha-melanocyte stimulating hormone modulates ethanol self-administration in posterior ventral tegmental area through melanocortin-4 receptors., PMID:24635847
Differential expression of the melanocortin-4 receptor in male and female C57BL/6J mice., PMID:24488261
Upregulation of hepatic melanocortin 4 receptor during rat liver regeneration., PMID:24433867
Effects of rabbit anti-α-melanocyte-stimulating hormone (α-MSH) immunoglobulins on α-MSH signaling related to food intake control., PMID:24238616
Agouti revisited: transcript quantification of the ASIP gene in bovine tissues related to protein expression and localization., PMID:22530003
The nutritional induction of COUP-TFII gene expression in ventromedial hypothalamic neurons is mediated by the melanocortin pathway., PMID:20976162
Neuroanatomical distribution of the melanocortin-4 receptors in male and female rodent brain., PMID:20884347
Melanocortin-4 receptor activation promotes insulin-stimulated mTOR signaling., PMID:20603172
A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration., PMID:20118207
Demonstration of the proopiomelanocortin signaling system in the primary immune organ of the quail., PMID:19456381
Anti-melanocortin-4 receptor autoantibodies in obesity., PMID:19050052
Antibodies as pharmacologic tools for studies on the regulation of energy balance., PMID:18662861
Melanocortin-4 receptor activation stimulates hypothalamic brain-derived neurotrophic factor release to regulate food intake, body temperature and cardiovascular function., PMID:18001327
Antibodies against the melanocortin-4 receptor act as inverse agonists in vitro and in vivo., PMID:17322114
Point mutations in the melanocortin-4 receptor cause variable obesity in mice., PMID:17143585
[D-Trp8]-gamma-melanocyte-stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse)., PMID:16959942
Detection of functionally active melanocortin receptors and evidence for an immunoregulatory activity of alpha-melanocyte-stimulating hormone in human dermal papilla cells., PMID:16081629
Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein., PMID:14962995
Putative targets of CNS melanocortin receptor activity., PMID:12851318
Pivotal roles of alpha-melanocyte-stimulating hormone and the melanocortin 4 receptor in leptin stimulation of prolactin secretion in rats., PMID:12675910
Specific detection of cell surface-displayed human melanocortin 4 receptors with antibodies generated in mice., PMID:11804330
Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat., PMID:10067869
For research use only. Not for human or drug use.
