Catalog No.
EHC40301
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Glu215
Predicted molecular weight
26.97 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P09429
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
High mobility group protein B1, HMGB1, HMG1, HMG-1, High mobility group protein 1
Role of vitamin D supplementation and vitamin D receptor in drug-resistant epilepsy: A double-blind placebo-controlled trial conducted in India., PMID:40516032
Single cell analysis and bioinformatics reveal pyroptosis mechanisms in hepatocellular carcinoma., PMID:40516009
HMGB1-Platelet Interactions: Mechanisms and Targeted Therapy Strategies., PMID:40514022
Hydroxysafflor Yellow A Ameliorates Ischemic Stroke by Inhibiting NLRP3, AIM2, and Pyrin Inflammasome-Mediated Pyroptosis., PMID:40512290
Arsenic Trioxide Enhances the Efficacy of PD-1 Inhibitors in Hepatocellular Carcinoma by Inducing Immunogenic Cell Death via the ROS/ERS Pathway., PMID:40504080
Multidirectional therapeutic effects of synthesized HMGB1 peptide on liver cirrhosis in mice., PMID:40503100
Studying Immunogenic Cell Death in Human Colorectal Cancer Organoids., PMID:40502372
HMGB1 mediates inflammation response of epileptogenicity in tuberous sclerosis complex-related epilepsy., PMID:40501216
Correction to "CMA down-regulates p53 expression through degradation of HMGB1 protein to inhibit irradiation-triggered apoptosis in hepatocellular carcinoma"., PMID:40497090
Syringetin ameliorates thallium sulphate induced renal dysfunction via regulating Nrf2/Keap-1, TLR4/HMGB1/RAGE and NF-κB pathway., PMID:40494130
Suppression of MRPL23 induces cellular senescence in hepatocellular carcinoma by targeting HMGB1., PMID:40490666
CMTM7 inhibits TLR4 signaling pathway via promoting Rab5 activation and alleviates acute liver injury., PMID:40490565
Acteoside ameliorates hepatocyte ferroptosis and hepatic ischemia-reperfusion injury via targeting PCBP2., PMID:40486855
Investigating the impact of berberine on autophagy-mediated drug resistance in chronic lymphocytic leukemia tumor cells., PMID:40473844
Investigating the mechanism of Gentiopicroside in rheumatoid arthritis through network pharmacology, molecular docking, and experimental validation., PMID:40473698
Expression of serum HMGB1, SAA, and TSGF in patients with colon cancer and the value of prognostic assessment., PMID:40468720
HMGB1 Mediates Microglia-Astrocyte/Neuron Crosstalk and Pyroptosis by the TLR4/NF-κB Pathway in Multiple Sclerosis., PMID:40464519
HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung-Associated Enterocolitis., PMID:40464207
Exploring the Effect and Mechanism of Liraglutide in Treating Depression Based on Network Pharmacology and Experimental Analysis., PMID:40461955
Impact of Corn Silk Extract on paclitaxel-induced spinal cord and sciatic nerve injuries in rats: Biochemical and histological evaluation., PMID:40460912
Patritumab deruxtecan induces immunogenic cell death., PMID:40458967
Predictive value of serum sortilin, HMGB1, and galanin-like peptide for gestational diabetes mellitus in women with polycystic ovary syndrome., PMID:40458174
HMGB1 Inhibition Alleviates Chronic Nonbacterial Prostatitis by Suppressing M1 Polarization of Macrophages., PMID:40453963
Dabrafenib stimulates autophagy in thyroid carcinoma cells via HMGB-1., PMID:40451856
Activation of Sig-1R by afobazole attenuates Tollip/HMGB1-mediaded CCN2 autophagic degradation and NETs formation in sunitinib-induced cardiotoxicity in mice: Involvement of IRE 1α/ASK1/JNK/ AP-1 trajectory., PMID:40449751
Role of HMGB1 on the onset of preeclampsia., PMID:40442700
Cardiomyocyte-localized CCDC25 senses NET DNA to promote doxorubicin cardiotoxicity by activating autophagic flux., PMID:40442366
GLUT1-mediated HMGB1 O-GlcNAcylation drives hyperglycemia-Induced neutrophil extracellular trap networks formation via TLR4 signaling and exacerbates fibroblast inflammation., PMID:40442314
Evaluating the adjuvant potential of NK-lysin and HMGB1-derived peptides in enhancing immune responses in Salmo salar., PMID:40441669
Evaluation of Tissue Expression of HMBG1 protein in Patients With Breast Cancer., PMID:40437918
Inhibition of NLRP3 Inflammasome Alleviates Postoperative Cognitive Impairment by Suppressing the HMGB-1/TLR4/NF-κB Pathway., PMID:40437299
A genome-wide base-editing screen uncovers a pivotal role of paxillin δ ubiquitination in influenza virus infection., PMID:40434888
3-Deoxysappanchalcone Inhibited High Mobility Group Box Protein 1-Mediated Severe Inflammatory Responses., PMID:40430548
Effects of Adipose-Derived Mesenchymal Stem Cell-Secretome on Pyroptosis of Laparoscopic Hepatic Ischemia Reperfusion Injury in a Porcine Model., PMID:40422225
Identification of a multiple DAMP scavenger mimicking the DAMP-binding site of TLR4 to ameliorate lethal sepsis., PMID:40421030
HMGB1/RAGE signaling mediates the activation of microglia and participates in depressive-like behaviors and cognitive deficits in rats after ischemia-reperfusion., PMID:40419119
Nesfatin-1 Suppresses Inflammation in Bronchopulmonary Dysplasia by Regulating HMGB-1/TLR4/p65/NLRP3 Signaling Pathway., PMID:40415368
The mechanism of ECT1/E6E7 cervical intraepithelial neoplasia cells regulated by Acinetobacter lwoffii through circ-LDHA/HMGB1., PMID:40414884
Omarigliptin ameliorates cisplatin-induced renal damage: Cross-talk between glucagon-like peptide-1, HMGB1/RAGE/TLR4 signaling, and TXNIP/NLRP3 inflammasome/gasdermin D axis., PMID:40414557
RIPK3-MLKL dependent necroptosis mediates depressive-like behavior by facilitating neuroinflammation., PMID:40408995
A light-regulated circadian timer optimizes neutrophil bactericidal activity to boost daytime immunity., PMID:40408429
11,12-Diacetyl-Carnosol Ameliorates Depression-Like Behaviors and Memory Dysfunction in CUMS Mouse Model via Inhibiting HMGB1-Mediated Neuroinflammation., PMID:40406924
Anti-DAMP therapies for acute inflammation., PMID:40406124
Trimetazidine improves dexamethasone-induced insulin resistance and associated hepatic abnormalities in rats., PMID:40404121
Kinetic Assessment of HMGB1 Exodus by Automated Live Cell Imaging., PMID:40402452
mTOR blockade mitigates chemotherapy drug-induced intestinal toxicity via inhibition of pyroptosis., PMID:40398827
Gardeniae Fructus extract terminates refractory status epilepticus with a wide time window through inhibiting neuroinflammation., PMID:40398000
Expression of thrombomodulin in pterygium: implications for inflammation and disease progression., PMID:40397236
A Role for High Mobility Group Box 1 (HMGB1) Release in the Pathogenesis of Gastroesophageal Reflux Disease., PMID:40391501
Decoding mechanisms and protein markers in lung-brain axis., PMID:40390067
For research use only. Not for human or drug use.
