Catalog No.
EHC39801
Description
CD48 is a 65 kDa GPI-linked protein which belongs to the CD2 subfamily of immunoglobulin superfamily molecules. CD48 antigen contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domain. CD48 antigen (Cluster of Differentiation 48) also known as B-lymphocyte activation marker (BLAST-1) or signaling lymphocytic activation molecule 2 (SLAMF2) is a protein that in humans is encoded by the CD48 gene. . Originally described on virally-induced B cells, CD48 has been found on various hematopoietic cells, and its expression is regulated by viral and bacterial products and immune-associated proteins.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Ser220
Predicted molecular weight
51.57 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P09326
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Signaling lymphocytic activation molecule 2, TCT.1, CD48 antigen, B-lymphocyte activation marker BLAST-1, BCM1, CD48, BLAST1, Leukocyte antigen MEM-102, SLAMF2, BCM1 surface antigen, SLAM family member 2
2B4 and CD48: A powerful couple of the immune system. PMID: 30366105
Roles of CD48 in regulating immunity and tolerance. PMID: 26794910
CD48: A co-stimulatory receptor of immunity. PMID: 20833258
CD48 is a key molecule of immunomodulation affecting prognosis in glioma. PMID: 31213836
CD48 as a novel target in asthma therapy. PMID: 19075961
Molecular characterization and expression of CD48 in Nile tilapia (Oreochromis niloticus) in response to different stimulus. PMID: 31846775
Acute myeloid leukemia immune escape by epigenetic CD48 silencing. PMID: 31922199
Human innate lymphoid cell precursors express CD48 that modulates ILC differentiation through 2B4 signaling. PMID: 33219153
AML1-ETO inhibits acute myeloid leukemia immune escape by CD48. PMID: 33225787
Divergent Traits and Ligand-Binding Properties of the Cytomegalovirus CD48 Gene Family. PMID: 32731344
CD27, CD201, FLT3, CD48, and CD150 cell surface staining identifies long-term mouse hematopoietic stem cells in immunodeficient non-obese diabetic severe combined immune deficient-derived strains. PMID: 31073070
The CD48 receptor mediates Staphylococcus aureus human and murine eosinophil activation. PMID: 25255823
CD48 controls T-cell and antigen-presenting cell functions in experimental colitis. PMID: 16472597
Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells. PMID: 29298288
CD48 and alpha7 Nicotinic Acetylcholine Receptor Synergistically Regulate FimH-Mediated Escherichia coli K1 Penetration and Neutrophil Transmigration Across Human Brain Microvascular Endothelial Cells. PMID: 30202861
Novel MHC-Independent alphabetaTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus. PMID: 32612609
Function of CD48 and its regulation by Epstein-Barr virus. PMID: 8132103
Subversion of natural killer cell responses by a cytomegalovirus-encoded soluble CD48 decoy receptor. PMID: 30947296
Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells. PMID: 27581174
CD48 on blood leukocytes and in serum of asthma patients varies with severity. PMID: 27859399
CD48 as a novel molecular target for antibody therapy in multiple myeloma. PMID: 22098460
Elevated Serum Level of CD48 in Patients with Intermittent Allergic Rhinitis. PMID: 32966985
CD48 is an allergen and IL-3-induced activation molecule on eosinophils. PMID: 16785501
Serum Soluble CD48 Levels as a Prognostic Marker in Mycosis Fungoides and Sezary Syndrome. PMID: 29605670
CD48 is critically involved in allergic eosinophilic airway inflammation. PMID: 17290046
Nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse. PMID: 18826951
Recurrent inflammatory disease caused by a heterozygous mutation in CD48. PMID: 31419545
SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors. PMID: 23827712
Mutational analysis of the epitopes recognized by anti-(rat CD2) and anti-(rat CD48) monoclonal antibodies. PMID: 7538945
CD48 is a low affinity ligand for human CD2. PMID: 7691954
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. PMID: 15989959
CD48 stimulation by 2B4 (CD244)-expressing targets activates human NK cells. PMID: 16585556
CD48 delivers an accessory signal for CD40-mediated activation of human B cells. PMID: 8929458
Evaluation of Soluble CD48 Levels in Patients with Allergic and Nonallergic Asthma in Relation to Markers of Type 2 and Non-Type 2 Immunity: An Observational Study. PMID: 30306094
TGF-beta regulated leukemia cell susceptibility against NK targeting through the down-regulation of the CD48 expression. PMID: 31421859
The oncogenic fusion protein CBFB-SMMHC downregulates CD48 to evade NK cell recognition. PMID: 29795444
CD48 may serve as an accessory molecule for the activation of a subset of human gamma/delta T cells. PMID: 8727206
CD48-deficient mice have a pronounced defect in CD4(+) T cell activation. PMID: 9927686
Anti-CD48 (murine CD2 ligand) mAbs suppress cell mediated immunity in vivo. PMID: 7521667
[Expression of CD48 as a live marker to distinguish division of hematopoietic stem cells]. PMID: 24989257
CD48-deficient T-lymphocytes from DMBA-treated rats have de novo mutations in the endogenous Pig-a gene. PMID: 26033714
Enhancement of antigen-specific immunoglobulin G responses by anti-CD48. PMID: 23208079
2B4/CD48-mediated regulation of lymphocyte activation and function. PMID: 16081768
CD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation. PMID: 21576698
CD48 Expression on Eosinophils in Nasal Polyps of Chronic Rhinosinusitis Patients. PMID: 33910197
Sequential cooperation of CD2 and CD48 in the buildup of the early TCR signalosome. PMID: 19494291
Unidirectional signaling triggered through 2B4 (CD244), not CD48, in murine NK cells. PMID: 20647560
Modulation of natural killer cell functions by interactions between 2B4 and CD48 in cis and in trans. PMID: 27249817
Case Report: Flow cytometric differential diagnosis of a peripheral T-cell lymphoma, NOS with complete loss of CD45 and dim expression of CD3., PMID:40510503
SGSM1 as a pan-cancer biomarker: multi-omics insights into immune regulation, prognostic value, and therapeutic implications., PMID:40500484
Integrating bioinformatics and machine learning to identify glomerular injury genes and predict drug targets in diabetic nephropathy., PMID:40374840
SAMSN1 causes sepsis immunosuppression by inducing macrophages to express coinhibitory molecules that cause T-cell exhaustion via KEAP1-NRF2 signaling., PMID:40293473
Comprehensive pan-cancer analysis identifies PLAG1 as a key regulator of tumor immune microenvironment and prognostic biomarker., PMID:40276502
DNA methylation-predicted plasma protein levels and breast cancer risk., PMID:40140843
Fibroblast IRF7-mediated chondrocyte apoptosis affects the progression of collapse in steroid-induced osteonecrosis of the femoral head., PMID:40102965
Sex differences alter primitive progenitors in the C57BL/6 Tet2 knockout mouse model., PMID:40015506
Functional study of tilapia T cell activation stimulus signal molecule CD2., PMID:39909121
Imaging of biphasic signalosomes constructed by checkpoint receptor 2B4 in conventional and chimeric antigen receptor-T cells., PMID:39886466
Integrated bioinformatics analysis identified cuproptosis-related hub gene Mpeg1 as potential biomarker in spinal cord injury., PMID:39814871
Urinary Immune Complexes Reflect Renal Pathology in Lupus Nephritis., PMID:39767148
Neutrophil Elastase Targets Select Proteins on Human Blood-Monocyte-Derived Macrophage Cell Surfaces., PMID:39684750
Deep phenotyping of T regulatory cells in psoriatic arthritis highlights targetable mechanisms of disease., PMID:39662827
Exploring diagnostic biomarkers of type 2 cardio-renal syndrome based on secreted proteins and bioinformatics analysis., PMID:39427047
High-Throughput Transcriptomics Identifies Chemoresistance-Associated Gene Expression Signatures in Human Angiosarcoma., PMID:39409192
In Situ Analyses of Placental Inflammatory Response to SARS-CoV-2 Infection in Cases of Mother-Fetus Vertical Transmission., PMID:39201511
Identification of gene and protein signatures associated with long-term effects of COVID-19 on the immune system after patient recovery by analyzing single-cell multi-omics data using a machine learning approach., PMID:39182316
Endomucin marks quiescent long-term multi-lineage repopulating hematopoietic stem cells and is essential for their transendothelial migration., PMID:38996072
CCR7 and CD48 as Predicted Targets in Acute Rejection Related to M1 Macrophage after Pediatric Kidney Transplantation., PMID:38957433
Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity., PMID:38896451
Identification of Immune Infiltrating Cell-Related Biomarkers in Early Gastric Cancer Progression., PMID:38860335
Exploring T-cell exhaustion features in Acute myocardial infarction for a Novel Diagnostic model and new therapeutic targets by bio-informatics and machine learning., PMID:38783198
Identification of potential biomarkers of leprosy: A study based on GEO datasets., PMID:38739634
Proteomics validate circulating GDF-15 as an independent biomarker for COVID-19 severity., PMID:38686386
Biomarker discovery with quantum neural networks: a case-study in CTLA4-activation pathways., PMID:38609844
Bahcc1 is critical for the aberrant epigenetic program in a mouse model of MLL-ENL-mediated leukemia., PMID:38452334
HERVK-mediated regulation of neighboring genes: implications for breast cancer prognosis., PMID:38388382
Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48., PMID:38386559
A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution., PMID:38374174
Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multiple myeloma., PMID:38355622
Gene signatures to therapeutics: Assessing the potential of ivermectin against t(4;14) multiple myeloma., PMID:38292661
The transcriptional and phenotypic characteristics that define alveolar macrophage subsets in acute hypoxemic respiratory failure., PMID:37978185
Seven chromatin regulators as immune cell infiltration characteristics, potential diagnostic biomarkers and drugs prediction in hepatocellular carcinoma., PMID:37903974
Exploring immune related gene signatures and mechanisms linking non alcoholic fatty liver disease to atrial fibrillation through transcriptome data analysis., PMID:37845390
Runx1-R188Q germ line mutation induces inflammation and predisposition to hematologic malignancies in mice., PMID:37756546
FCGR2B as a prognostic and immune microenvironmental marker for gliomas based on transcriptomic analysis., PMID:37713871
Combination of CD49b and CD229 Reveals a Subset of Multipotent Progenitors With Short-Term Activity Within the Hematopoietic Stem Cell Compartment., PMID:37706539
2B4: A potential target in Staphylococcus aureus associated allergic inflammation., PMID:37583293
Involvement of KLRK1 in immune infiltration of head and neck squamous cell carcinoma correlates with favorable prognosis., PMID:37565867
2B4 inhibits the apoptosis of natural killer cells through phosphorylated extracellular signal-related kinase/B-cell lymphoma 2 signal pathway., PMID:37516949
Impact of HIV-1 Vpu-mediated downregulation of CD48 on NK-cell-mediated antibody-dependent cellular cytotoxicity., PMID:37404017
Immune response of DNA vaccinated-gilthead seabream (Sparus aurata) against LCDV-Sa infection: relevance of the inflammatory process., PMID:37346045
CD48 suppresses proliferation and migration as an immune-related prognostic signature in the cervical cancer immune microenvironment., PMID:37279525
The hyperinflammatory spectrum: from defects in cytotoxicity to cytokine control., PMID:37187762
WGCNA and molecular docking identify hub genes for cardiac aging., PMID:37180776
Integrative analyses of biomarkers and pathways for diabetic nephropathy., PMID:37113991
Deep learning on graphs for multi-omics classification of COPD., PMID:37083575
Uncovering the Underworld of Axial Spondyloarthritis., PMID:37047435
Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity., PMID:36891288
For research use only. Not for human or drug use.
