Catalog No.
RHD44703
Species reactivity
Human, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IP: 1:20, WB: 1:500-1:1000
Target
Heparin-binding neurite outgrowth-promoting factor 1, Heparin-binding brain mitogen, PTN, HBGF-8, Pleiotrophin, Heparin-binding growth factor 8, HBBM, HBNF-1, NEGF1, Osteoblast-specific factor 1, HBNF, HBNF1, Heparin-binding growth-associated molecule, HB-GAM, OSF-1, Heparin-binding neurite outgrowth-promoting factor
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P21246
Applications
IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1R73
Ping pong chrysanthemum-like Bi-BiOI and ternary core-shell structured Pd@AuPt based dual-electric signal outputs biosensor for accurate detection of CA19 - 9., PMID:40261434
Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins., PMID:39525569
Intra-channel bi-epitopic crosslinking unleashes ultrapotent antibodies targeting NaV1.7 for pain alleviation., PMID:39461335
Pleiotrophin Activates cMet- and mTORC1-Dependent Protein Synthesis through PTPRZ1-The Role of ανβ3 Integrin., PMID:39409168
Efficient CdIn2S4/MgIn2S4 heterojunction for ultrasensitive detection of lung cancer marker neuron-specific enolase., PMID:39153254
An electrochemical ratiometric immunosensor for the detection of NMP22 based on ZIF-8@MWCNTs@Chit@Fc@AuNPs and AuPt-MB., PMID:39046279
A Polymer-Based Antigen Carrier Activates Two Innate Immune Pathways for Adjuvant-Free Subunit Vaccines., PMID:38478910
Engineered Histidine-Rich Peptides Enhance Endosomal Escape for Antibody-Targeted Intracellular Delivery of Functional Proteins., PMID:37283024
A pH-dependent anti-CD47 antibody that selectively targets solid tumors and improves therapeutic efficacy and safety., PMID:36650558
A cross-reactive pH-dependent EGFR antibody with improved tumor selectivity and penetration obtained by structure-guided engineering., PMID:36458200
An anti-CD98 antibody displaying pH-dependent Fc-mediated tumour-specific activity against multiple cancers in CD98-humanized mice., PMID:36424464
PTN-PTPRZ1 signaling axis blocking mediates tumor microenvironment remodeling for enhanced glioblastoma treatment., PMID:36402232
TDO2+ myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma., PMID:35972800
Binding of pleiotrophin to cell surface nucleolin mediates prostate cancer cell adhesion to osteoblasts., PMID:35461017
Risk factors of herpes simplex virus reactivation after surgery for primary trigeminal neuralgia., PMID:35334082
Hydrophobic Localized Enrichment of Co-reactants to Enhance Electrochemiluminescence of Conjugated Polymers for Detecting SARS-CoV-2 Nucleocapsid Proteins., PMID:35230820
A sandwich-type electrochemical immunosensor using trimetallic nanozyme as signal amplification for NT-proBNP sensitive detection., PMID:35101800
Avelumab in patients with previously treated metastatic Merkel cell carcinoma (JAVELIN Merkel 200): updated overall survival data after >5 years of follow-up., PMID:34715570
A bispecific antibody targeting GPC3 and CD47 induced enhanced antitumor efficacy against dual antigen-expressing HCC., PMID:33429083
Genetically encoded tags for direct synthesis of EM-visible gold nanoparticles in cells., PMID:32778831
Phase 2 study of pembrolizumab for measurable residual disease in adults with acute lymphoblastic leukemia., PMID:32692850
Pleiotrophin selectively binds to vascular endothelial growth factor receptor 2 and inhibits or stimulates cell migration depending on ανβ3 integrin expression., PMID:32681389
Avelumab in patients with previously treated metastatic Merkel cell carcinoma: long-term data and biomarker analyses from the single-arm phase 2 JAVELIN Merkel 200 trial., PMID:32414862
Estrogen Stimulation of Pleiotrophin Enhances Osteoblast Differentiation and Maintains Bone Mass in IGFBP-2 Null Mice., PMID:32168373
Novel Abs targeting the N-terminus of fibroblast growth factor 19 inhibit hepatocellular carcinoma growth without bile-acid-related side-effects., PMID:32061104
Conditioned Medium from Human Tonsil-Derived Mesenchymal Stem Cells Enhances Bone Marrow Engraftment via Endothelial Cell Restoration by Pleiotrophin., PMID:31952360
Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling., PMID:31613796
Risk factors of hippocampal sclerosis in the oldest old: The 90+ Study., PMID:30315072
Identification of methylation sites and signature genes with prognostic value for luminal breast cancer., PMID:29642861
Prematurity disrupts glomeruli development, whereas prematurity and hyperglycemia lead to altered nephron maturation and increased oxidative stress in newborn baboons., PMID:29166383
A potent human neutralizing antibody Fc-dependently reduces established HBV infections., PMID:28949917
Spatiotemporal expression profiling of long intervening noncoding RNAs in Caenorhabditis elegans., PMID:28701691
Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth., PMID:28569747
Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION., PMID:27445335
Fulranumab in Patients With Pain Associated With Postherpetic Neuralgia and Postraumatic Neuropathy: Efficacy, Safety, and Tolerability Results From a Randomized, Double-blind, Placebo-controlled, Phase-2 Study., PMID:27153360
PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma., PMID:27093365
Vascular endothelial growth factor A (VEGF-A) decreases expression and secretion of pleiotrophin in a VEGF receptor-independent manner., PMID:26924457
Pleiotrophin exerts its migration and invasion effect through the neuropilin-1 pathway., PMID:26408254
A self-enhanced electrochemiluminescence immunosensor based on L-Lys-Ru(dcbpy)3(2+) functionalized porous six arrises column nanorods for detection of CA15-3., PMID:26257184
Response of layer and broiler strain chickens to parenteral administration of a live Salmonella Typhimurium vaccine., PMID:26009756
EGFR trans-activation mediates pleiotrophin-induced activation of Akt and Erk in cultured osteoblasts., PMID:24727451
Elevated expression of pleiotrophin in lymphocytic leukemia CD19+ B cells., PMID:24698102
Autoimmune neutropenia after kidney transplantation: a disregarded entity of posttransplant neutropenia., PMID:24598937
Intranasal immunization with W 80 5EC adjuvanted recombinant RSV rF-ptn enhances clearance of respiratory syncytial virus in a mouse model., PMID:24326268
Evaluation of hypertension and proteinuria as markers of efficacy in antiangiogenic therapy for metastatic colorectal cancer., PMID:24153157
ALK receptor activation, ligands and therapeutic targeting in glioblastoma and in other cancers., PMID:23267434
Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche., PMID:23084748
Pleiotrophin (PTN) expression and function and in the mouse mammary gland and mammary epithelial cells., PMID:23077670
Implications of pleiotrophin in human PC3 prostate cancer cell growth in vivo., PMID:22783964
Effect of HER2 status on risk of recurrence in women with small, node-negative breast tumours., PMID:22059233
For research use only. Not for human or drug use.
