Catalog No.
YHC35701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala20-Phe152
Predicted molecular weight
16.71 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P08700
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL3, Hematopoietic growth factor, Multipotential colony-stimulating factor, IL-3, Mast cell growth factor, Interleukin-3, P-cell-stimulating factor, MCGF
Novel ETV6::RAPGEF6 fusion gene in chronic eosinophilic leukemia: compiling evidence on the role of IL3 overexpression in tumorigenesis., PMID:39923209
The Meq Genes of Nigerian Marek's Disease Virus (MDV) Field Isolates Contain Mutations Common to Both European and US High Virulence Strains., PMID:39861844
A γδ T cell-IL-3 axis controls allergic responses through sensory neurons., PMID:39232162
Efficient production of human interleukin-3 from Escherichia coli using protein disulfide isomerase b'a' domain., PMID:38719587
Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling., PMID:38614096
ETV6::ACSL6 translocation-driven super-enhancer activation leads to eosinophilia in acute lymphoblastic leukemia through IL-3 overexpression., PMID:38356460
Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis., PMID:38299881
Acute myeloid leukemia-driven IL-3-dependent upregulation of BCL2 in non-malignant hematopoietic stem and progenitor cells increases venetoclax-induced cytopenias., PMID:38186347
Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis., PMID:37160117
Interleukin-3 protects against viral pneumonia in sepsis by enhancing plasmacytoid dendritic cell recruitment into the lungs and T cell priming., PMID:36911737
Conformational and binding mode assessment of the human IL-3 recognition by its alpha receptor., PMID:36729088
IL3 Has a Detrimental Effect on Hematopoietic Stem Cell Self-Renewal in Transplantation Settings., PMID:36361533
An Immunoregulatory Role of Interleukin-3 in Allergic Asthma., PMID:35281014
Molecular Mechanisms of Eosinophilic Esophagitis., PMID:34947981
The association between serum level and genetic variation of IL-3 (rs40401) in recurrent abortion women infected with toxoplasmosis in Iraq., PMID:34619417
Demonstration and implications of IL-3 upregulation of CD25 expression on human mast cells., PMID:34506850
Serum Inflammatory Factor Profiles in the Pathogenesis of High-Altitude Polycythemia and Mechanisms of Acclimation to High Altitudes., PMID:34483727
Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease., PMID:34262178
Clinical utility of next generation sequencing to detect IGH/IL3 rearrangements [t(5;14)(q31.1;q32.1)] in B-lymphoblastic leukemia/lymphoma., PMID:33991782
Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections., PMID:33602937
The Inflammatory Cytokine IL-3 Hampers Cardioprotection Mediated by Endothelial Cell-Derived Extracellular Vesicles Possibly via Their Protein Cargo., PMID:33374685
MYC-induced human acute myeloid leukemia requires a continuing IL-3/GM-CSF costimulus., PMID:33301029
Bovine β-lactoglobulin-induced passive systemic anaphylaxis model using humanized NOG hIL-3/hGM-CSF transgenic mice., PMID:33027513
Interleukin 3-induced GITR promotes the activation of human basophils., PMID:32889153
CRISPR-Cas9-Mediated ELANE Mutation Correction in Hematopoietic Stem and Progenitor Cells to Treat Severe Congenital Neutropenia., PMID:32822592
High-risk B-cell acute lymphoblastic leukaemia presenting with hypereosinophilia and acquiring a novel PAX5 fusion on relapse., PMID:32731299
A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification., PMID:32327499
The RNFT2/IL-3Rα axis regulates IL-3 signaling and innate immunity., PMID:31990690
A humanized mouse model to study mast cells mediated cutaneous adverse drug reactions., PMID:31922289
IL-3 Receptor Expression on Activated Human Th Cells Is Regulated by IL-4, and IL-3 Synergizes with IL-4 to Enhance Th2 Cell Differentiation., PMID:31900339
Eosinophil cytolysis on Immunoglobulin G is associated with microtubule formation and suppression of rho-associated protein kinase signalling., PMID:31750580
SS30, a novel thioaptamer targeting CD123, inhibits the growth of acute myeloid leukemia cells., PMID:31323275
Human Eosinophils Express a Distinct Gene Expression Program in Response to IL-3 Compared with Common β-Chain Cytokines IL-5 and GM-CSF., PMID:31175163
Levels of cytokines and GADA in type I and II diabetic patients., PMID:31014937
Stepping out of the shadow: STIM2 promotes IL-3-induced cytokine release., PMID:30967511
Interleukin-3 Polymorphism is Associated with Miscarriage of Fresh in Vitro Fertilization Cycles., PMID:30893922
Tagraxofusp: First Global Approval., PMID:30859413
Malignant Transformation of Fanconi Anemia Complementation Group D2-deficient (Fancd2 -/-) Hematopoietic Progenitor Cells by a Single HPV16 Oncogene., PMID:30804107
An objective flow cytometry method to rapidly determine cord blood potency in cryopreserved units., PMID:30802338
Role of interleukin-3 as a prognostic marker in septic patients., PMID:30652781
Expression of IL-3 receptors and impact of IL-3 on human T and B cells., PMID:30274838
Paraneoplastic hypereosinophilic syndrome associated with IL3-IgH positive acute lymphoblastic leukemia., PMID:30207070
Comparative utility of NRG and NRGS mice for the study of normal hematopoiesis, leukemogenesis, and therapeutic response., PMID:30125602
Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation., PMID:29948855
IL-3 but not monomeric IgE regulates FcεRI levels and cell survival in primary human basophils., PMID:29724998
IL-2/IL-3 interplay mediates growth of CD25 positive acute myeloid leukemia cells., PMID:29685196
Interleukin-3, symptoms and cognitive deficits in first-episode drug-naïve and chronic medicated schizophrenia., PMID:29554544
Celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 polarization., PMID:29540209
A case of B-cell precursor acute lymphoblastic leukemia with IL3-IGH rearrangement revealed by thromboembolism and marked eosinophilia., PMID:29424254
Combined effect of gene dosage and process optimization strategies on high-level production of recombinant human interleukin-3 (hIL-3) in Pichia pastoris fed-batch culture., PMID:29113894
For research use only. Not for human or drug use.
