Catalog No.
YHC35501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu107-Gly390
Predicted molecular weight
34.48 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P08686
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CYP21, CYP21B, Cytochrome P450 21, Cytochrome P450-C21B, Cytochrome P450-C21, Cytochrome P450 XXI, 21-OHase, Steroid 21-hydroxylase, Cytochrome P-450c21, CYP21A2
A Cross-Tissue Transcriptome-Wide Association Study Reveals Novel Susceptibility Genes for Diabetic Kidney Disease in the FinnGen Cohort., PMID:40427057
Genetic Profiling of Synchronous Pituitary Corticotroph Adenomas., PMID:40386408
Combination therapy of GnRHa, RhGH and anastrozole to improve final adult height deficit in CAH children with CPP., PMID:40329244
The distinctive P450 oxidoreductase (PORD) urinary steroid metabolome in the first week of life: Report of three cases with severe disorder., PMID:40222686
Identification of a Homozygous Variant in the CYP21A2 Gene by Next-Generation Sequencing Analysis of Circulating Cell-Free Fetal DNA., PMID:40149462
Adrenal steroid hormone responses to exercise under thermal stress: Potential role for nonclassic congenital adrenal hyperplasia in heat illness susceptibility., PMID:40110968
Exploring antigenic variation in autoimmune endocrinopathy., PMID:40093006
Mitotane activates ATF4/ATF3 axis triggering endoplasmic reticulum stress in adrenocortical carcinoma cells., PMID:39965324
Nationwide carrier screening for congenital adrenal hyperplasia: integrated approach of CYP21A2 pathogenic variant genotyping and comprehensive large gene deletion analysis., PMID:39856693
Genetics and Pathophysiology of Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency., PMID:39836621
High clinical utility of long-read sequencing for precise diagnosis of congenital adrenal hyperplasia in 322 probands., PMID:39810276
Treatment and Follow-up of Congenital Adrenal Hyperplasia Due to 21-hydroxylase Deficiency in Childhood and Adolescence., PMID:39713876
Clinical, Biochemical and Molecular Characteristics of Congenital Adrenal Hyperplasia Due to 21-hydroxylase Deficiency., PMID:39713855
[Detection and characterization of the types of CYP21A1P/CYP21A2 and TNXA/TNXB fused genes by long-read sequencing among children with Steroid 21-hydroxylase deficiency]., PMID:39653346
Long-Read Sequencing Identifying the Genetic Complexity of Congenital Adrenal Hyperplasia in the Pedigree., PMID:39575462
Disordered Electron Transfer: New Forms of Defective Steroidogenesis and Mitochondriopathy., PMID:39574227
Severe Hyperandrogenism in 46,XX Congenital Adrenal Hyperplasia: Molecular Physiopathology, Late Diagnoses, and Personalized Management., PMID:39519330
Genomic complexity and clinical significance of the RCCX locus., PMID:39512309
Novel rapid molecular diagnosis methods for comprehensive genetic analysis of 21-hydroxylase deficiency., PMID:39468716
Causal and mediating effects of lipid and facial aging: association study integrating GWAS, eQTL, mQTL, and pQTL data., PMID:39434152
Unveiling potential drug targets for lung squamous cell carcinoma through the integration of druggable genome and genome-wide association data., PMID:39175755
Genotype and Phenotype of 21-Hydroxylase Deficiency: A Single Center Experience from Western India., PMID:39051316
Long-Read Sequencing Solves Complex Structure of CYP21A2 in a Large 21-Hydroxylase Deficiency Cohort., PMID:39049755
Classic congenital adrenal hyperplasia with unilateral functional adrenal cortical adenoma: case report., PMID:39034929
Diagnostic Value of Autoantibodies against Steroidogenic Enzymes and Hormones in Infertile Women with Premature Ovarian Insufficiency., PMID:38928251
Improved Genetic Characterization of Congenital Adrenal Hyperplasia by Long-Read Sequencing Compared with Multiplex Ligation-Dependent Probe Amplification Plus Sanger Sequencing., PMID:38925455
Congenital Adrenal Hyperplasia with Combined 21-hydroxylase deficiency and 17α-hydroxylase/17,20-lyase deficiency: An undervirilized male., PMID:38852772
Biochemical monitoring of 21-hydroxylase deficiency: a clinical utility of overnight fasting urine pregnanetriol., PMID:38832930
Rapid detection of common variants and deletions of CYP21A2 using MALDI-TOF MS., PMID:38830573
Genetic Disruption of cyp21a2 Leads to Systemic Glucocorticoid Deficiency and Tissues Hyperplasia in the Teleost Fish Medaka (Oryzias latipes)., PMID:38809865
A Humanized and Viable Animal Model for Congenital Adrenal Hyperplasia-CYP21A2-R484Q Mutant Mouse., PMID:38791102
NR1I2 as a core biological target in chronic venous ulcer tissues treated with ultrasound therapy., PMID:38728468
Can Incorporating Molecular Testing Improve the Accuracy of Newborn Screening for Congenital Adrenal Hyperplasia?, PMID:38701341
Case report: Development of central precocious puberty in a girl with late-diagnosed simple virilizing congenital adrenal hyperplasia complicated with Williams syndrome., PMID:38699383
Genetic diagnosis of endocrine disorders in Cyprus through the Cyprus Institute of Neurology and Genetics: an ENDO-ERN Reference Center., PMID:38637882
Association of seasonal changes in circulating cortisol concentrations with the expression of cortisol biosynthetic enzymes and a glucocorticoid receptor in the blubber of common bottlenose dolphin., PMID:38593942
Giant Bilateral Adrenal Myelolipomas in a Non-Compliant Patient with Congenital Adrenal Hyperplasia., PMID:38582958
Exploration and biological evaluation of 20-vinyl pregnenes: A step forward toward selective modulators of the estrogen receptor α signaling for breast cancer treatment., PMID:38570819
[Not Available]., PMID:38533865
High carrier frequency of CYP21A2 gene mutations in Southern India - underscoring the need for genetic testing in Congenital Adrenal Hyperplasia., PMID:38441846
Evaluating the efficacy of a long-read sequencing-based approach in the clinical diagnosis of neonatal congenital adrenocortical hyperplasia., PMID:38307397
The intrafollicular concentrations of biologically active cortisol in women rise abruptly shortly before ovulation and follicular rupture., PMID:38268234
Familial ApoB-specific familial hypobetalipoproteinemia in a patient with non-classical congenital adrenal hyperplasia., PMID:38195282
Genetic prediction of antihyperglycemic drug targets and risk of epilepsy: a mendelian randomisation study., PMID:38167102
Navigating the Complex Landscape of CYP21A2 Variants., PMID:38117440
A novel SMOC1 pathogenic homozygous variant in a fetus with mesomelia of the lower limbs, micrognathia and hypertelorism and an incidental finding of CYP21A2-related congenital adrenal hyperplasia., PMID:38059661
Growth and Treatment in Congenital Adrenal Hyperplasia: An Observational Study from Diagnosis to Final Height., PMID:38016434
[Clinical, genetic, and pathological analysis in 165 children with disorders of sex development]., PMID:37990456
Determination of Carrier Frequency of Actionable Pathogenic Variants in Autosomal Recessive Genetic Diseases in the Turkish Cypriot Population., PMID:37895316
Targeted long-read sequencing for comprehensive detection of CYP21A2 mutations in patients with 21-hydroxylase deficiency., PMID:37815751
For research use only. Not for human or drug use.
