Catalog No.
YHC34901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met22-Pro526
Predicted molecular weight
59.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P08631
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Hemopoietic cell kinase, Tyrosine-protein kinase HCK, p61Hck, p59-HCK/p60-HCK, Hematopoietic cell kinase, p59Hck, HCK
HCK regulates NLRP12-mediated PANoptosis., PMID:40408404
Variant mutation G215C in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation., PMID:40299982
Biological evaluation as antimalarial of two families of biscationic compounds featuring two different sulphur linkers., PMID:40246180
An unconventional T cell nexus drives HCK-mediated chronic obstructive pulmonary disease in mice., PMID:40245497
Using weighted gene co-expression network analysis to identify key genes related to preeclampsia., PMID:40207223
DCC-2036 inhibits osteosarcoma via targeting HCK and the PI3K/AKT-mTORC1 axis to promote autophagy., PMID:40176057
Bioinformatics Approach to Investigating the Immuno-Inflammatory Mechanisms of Periodontitis in the Progression of Atherosclerosis., PMID:40136451
Identifcation of the FGF family as therapeutic targets and prognostic biomarkers in the microenvironment of head and neck squamous cell carcinoma., PMID:40086631
Exploring the role of TIGIT in patients with Small Cell Lung Cancer as a novel predictor of prognosis and immunotherapy response., PMID:40035834
Identification of biomarkers associated with phagocytosis regulatory factors in coronary artery disease using machine learning and network analysis., PMID:39953122
Characteristics and prognosis of patients with primary metastatic disease vs. recurrent HER2-negative, hormone receptor-positive advanced breast cancer., PMID:39952220
Inhibition of Kinase Activity and In Vitro Downregulation of the Protein Kinases in Lung Cancer and Cervical Cancer Cell Lines and the Identified Known Anticancer Compounds of Ziziphus mucronata., PMID:39942957
Revealing distinct treatment mechanisms and outcome correlations in patients with interstitial cystitis/bladder pain syndrome after different bladder therapies through urinary biomarker analysis., PMID:39878889
Identification of Immune Infiltration-Associated CC Motif Chemokine Ligands as Biomarkers and Targets for Colorectal Cancer Prevention and Immunotherapy., PMID:39859340
Regulation of interferon alpha production by the MAGUK-family protein CASK under H5N1 infection., PMID:39850902
Molecular Design, Synthesis and Anti-cancer Activity of Novel Pyrazolo[3,4-b]pyridine-based Glycohybrid Molecules., PMID:39848166
Bioinformatic Analysis for Exploring Target Genes and Molecular Mechanisms of Cadmium-Induced Nonalcoholic Fatty Liver Disease and Targeted Drug Prediction., PMID:39806544
Urinary TYROBP and HCK as genetic biomarkers for non-invasive diagnosis and therapeutic targeting in IgA nephropathy., PMID:39777260
Constitutive activation of the Src-family kinases Fgr and Hck enhances the tumor burden of acute myeloid leukemia cells in immunocompromised mice., PMID:39747387
Upregulation of haematopoetic cell kinase (Hck) activity by a secreted parasite effector protein (Ta9) drives proliferation of Theileria annulata-transformed leukocytes., PMID:39730099
Hck promotes IL-1β-induced extracellular matrix degradation, inflammation, and apoptosis in osteoarthritis via activation of the JAK-STAT3 signaling pathway., PMID:39696562
An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck., PMID:39675702
Utilizing AI for the Identification and Validation of Novel Therapeutic Targets and Repurposed Drugs for Endometriosis., PMID:39666559
Pelvic floor muscle pain is associated with higher symptom scores and bladder pain perception in women with interstitial cystitis and bladder pain syndrome., PMID:39625572
Identification of mRNA biomarkers in extremely early hypertensive intracerebral hemorrhage (HICH)., PMID:39616335
The role of macrophage migratory behavior in development, homeostasis and tumor invasion., PMID:39588367
Revealing the antioxidant properties of alkyl gallates: a novel approach through quantum chemical calculations and molecular docking., PMID:39542935
Identification of late-stage tau accumulation using plasma phospho-tau217., PMID:39500009
Loss of CCL28 and CXCL17 Expression and Increase in CCR1 Expression May Be Related to Malignant Transformation of LGBLEL into Lymphoma., PMID:39451532
The impact of physical activity on progression-free and overall survival in metastatic breast cancer based on molecular subtype., PMID:39415149
Proteomic Characterization of Corneal Epithelial and Stromal Cell-Derived Extracellular Vesicles., PMID:39408670
The Effect of Vitamin D Deficiency on Immune-Related Hub Genes: A Network Analysis Associated With Type 1 Diabetes., PMID:39371824
Cocrystallization of the Src-Family Kinase Hck with the ATP-Site Inhibitor A-419259 Stabilizes an Extended Activation Loop Conformation., PMID:39315638
Integrative Analysis and Validation of a Cancer-associated Fibroblasts Senescence-related Signature for Risk Stratification and Therapeutic Prediction in Esophageal Squamous Cell Carcinoma., PMID:39308671
Cellulose nano-dispersions enhanced by ultrasound assisted chemical modification drive osteoblast proliferation and differentiation in PVA/HA bone tissue engineering scaffolds., PMID:39276883
Resorbable Microspheres versus Trisacryl Gelatin Microspheres for Uterine Artery Embolization: A Randomized Controlled Trial., PMID:39254451
Knockdown of HCK promotes HREC cell viability and inner blood-retinal barrier integrity by regulating the AMPK signaling pathway., PMID:39247797
Resveratrol attenuates non-steroidal anti-inflammatory drug-induced intestinal injury in rats in a high-altitude hypoxic environment by modulating the TLR4/NFκB/IκB pathway and gut microbiota composition., PMID:39133675
[Screening and validation of therapeutic targets for chronic sinusitis with nasal polyps based on proteomics]., PMID:39107122
The Evolving Role of Bruton's Tyrosine Kinase Inhibitors in B Cell Lymphomas., PMID:39062757
CD3ζ-Mediated Signaling Protects Retinal Ganglion Cells in Glutamate Excitotoxicity of the Retina., PMID:38920637
Integrated mRNA-miRNA transcriptome profiling of blood immune responses potentially related to pulmonary fibrosis in forest musk deer., PMID:38873601
A synergistic mechanism of Liquiritin and Licochalcone B from Glycyrrhiza uralensis against COPD., PMID:38870751
Efficient synthesis of indole-chalcones based glycohybrids and their anticancer activity., PMID:38870714
Recent advances in hematopoietic cell kinase in cancer progression: Mechanisms and inhibitors., PMID:38870631
Identification and validation of lipid metabolism-related key genes as novel biomarkers in acute myocardial infarction and pan-cancer analysis., PMID:38787365
Interaction of T-cell-specific adapter protein with Src- and Tec-family kinases., PMID:38605535
Serum chemistry profiling and prognostication in systemic mastocytosis: a registry-based study of the ECNM and GREM., PMID:38593217
Variant mutation in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation., PMID:38559000
Extraction of Innate Immune Genes in Dairy Cattle and the Regulation of Their Expression in Early Embryos., PMID:38540431
For research use only. Not for human or drug use.
