Catalog No.
YHC31501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly789-Lys984
Predicted molecular weight
50.00 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P08235
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NR3C2, MR, Mineralocorticoid receptor, MCR, Nuclear receptor subfamily 3 group C member 2, MLR
Lipidomics reveals effect of EHHADH in lung squamous cell., PMID:40450155
Hypertension and hyperkalemia associated with Pro701Leu mutation in the NR3C2 gene: A case report., PMID:40441250
Resveratrol Alleviates Ischemia-Reperfusion-Induced Neuronal Damage by Inhibiting NR3C2-Mediated TRIM28 Expression., PMID:40302259
Probiotic Bactolac alleviates depression-like behaviors by modulating BDNF, NLRP3 and MC4R levels, reducing neuroinflammation and promoting neural repair in rat model., PMID:40281288
Effect and underlying mechanism of Huangjing Qianshi decoction in pre-diabetes mouse model., PMID:40269867
The NR3C2-SIRT1 signaling axis promotes autophagy and inhibits epithelial mesenchymal transition in colorectal cancer., PMID:40229278
HPA-axis multilocus genetic interaction with stress life events in predicting changes in adolescent suicidal ideation., PMID:40139404
Aloin blocks the malignant behavior of lung squamous cell carcinoma cells and M2 macrophage polarization by modulating the NR3C2/MT1M axis., PMID:40102085
Renal pseudohypoaldosteronism type 1-an adult case series including a novel gene variant., PMID:39614070
The potential of Gynostemma pentaphyllum in the treatment of hyperlipidemia and its interaction with the LOX1-PI3K-AKT-eNOS pathway., PMID:39479713
Mineralocorticoid receptor expression and the effects of the mineralocorticoid receptor antagonist spironolactone in a murine model of graft-versus-host disease., PMID:39424225
Sex-dependent effects of acute stress and alcohol exposure during adolescence on mRNA expression of brain signaling systems involved in reward and stress responses in young adult rats., PMID:39327618
Effects of L-NAME and air exposure on mitochondrial energetic markers, thyroid hormone receptor/regulator system and stress/ease-responsive receptor expression in the brain/gut axis of zebrafish., PMID:39306267
NR3C2 affects the proliferation and invasiveness of colon cancer cells through the Wnt/β-Catenin signaling pathway., PMID:39237674
Prenatal exposure to the mineralocorticoid receptor antagonist spironolactone disrupts hippocampal area CA2 connectivity and alters behavior in mice., PMID:39237618
Psoriatic skin transcript phenotype: androgen/estrogen and cortisone/cortisol imbalance with increasing DNA damage response., PMID:39180588
Co-Expression Network Analysis and Molecular Docking Demonstrate That Diosgenin Inhibits Gastric Cancer Progression via SLC1A5/mTORC1 Pathway., PMID:39071813
Molecular evidence of altered stress responsivity related to neuroinflammation in the schizophrenia midbrain., PMID:39004003
Network Pharmacology and Molecular Docking Validation to Explore the Pharmacological Mechanism of Zhuling Decoction against Nephrotic Syndrome., PMID:38910482
An in Vitro triple screen model for human mineralocorticoid receptor activity., PMID:38866188
Early life stress unravels epistatic genetic associations of cortisol pathway genes with depression., PMID:38759498
The multifaceted role of the mineralocorticoid receptor in cancers., PMID:38714226
Autosomal Dominant Pseudohypoaldosteronism Type 1 in a Newborn With Failure to Thrive., PMID:38689677
MIF/NR3C2 axis regulates glucose metabolism reprogramming in pancreatic cancer through MAPK-ERK and AP-1 pathways., PMID:38629149
Key HPI axis receptors facilitate light adaptive behavior in larval zebrafish., PMID:38565594
Age-related increase in the expression of 11β-hydroxysteroid dehydrogenase type 1 in the hippocampus of male rhesus macaques., PMID:38560025
Dissecting the Long-Term Effect of Stress Early in Life on FKBP5: The Role of miR-20b-5p and miR-29c-3p., PMID:38540789
NR3C2 microdeletions-an underrecognized cause of pseudohypoaldosteronism type 1A: a case report and literature review., PMID:38493321
Identification and validation of CCR5 linking keloid with atopic dermatitis through comprehensive bioinformatics analysis and machine learning., PMID:38476235
Mineralocorticoid Receptor and Aldosterone: Interaction Between NR3C2 Genetic Variants, Sex, and Age in a Mixed Cohort., PMID:38437868
The effects of childhood maltreatment, recent interpersonal and noninterpersonal stress, and HPA-axis multilocus genetic variation on prospective changes in adolescent depressive symptoms: A multiwave longitudinal study., PMID:38389485
The Long Non-Coding RNA NR3C2-8:1 Promotes p53-Mediated Apoptosis through the miR-129-5p/USP10 Axis in Amyotrophic Lateral Sclerosis., PMID:38388775
The dynamic landscape of chromatin accessibility and active regulatory elements in the mediobasal hypothalamus influences the seasonal activation of the reproductive axis in the male quail under long light exposure., PMID:38373887
Mineralocorticoid promotes intestinal inflammation through receptor dependent IL17 production in ILC3s., PMID:38368773
The impact of parental and developmental stress on DNA methylation in the avian hypothalamic-pituitary-adrenal axis., PMID:38343177
Mineralocorticoid receptor promotes cardiac macrophage inflammaging., PMID:38329499
Neurobehavioral Abnormalities in Offspring of Young Adult Male Rats With a History of Traumatic Brain Injury., PMID:38279844
First Evidence of Mineralocorticoid Receptor Gene and Protein Expression in Rat and Human Thyroid Tissues and Cell Cultures., PMID:38255827
Clinical analysis of salt-wasting in infants due to genetic aetiology., PMID:40091330
Propofol-induced LINC01133 inhibits the progression of colorectal cancer via miR-186-5p/NR3C2 axis., PMID:38146619
Mineralocorticoid receptor overactivation: targeting systemic impact with non-steroidal mineralocorticoid receptor antagonists., PMID:38127122
Therapeutic effect of microRNA-21 on differentially expressed hub genes in gastric cancer based on systems biology., PMID:38081950
Effects of environmental and genetic interactions on job burnout in coal miners: interactions between occupational stress, coping styles, and NR3C2 gene polymorphisms., PMID:38054065
Temperature- and genotype-dependent stress response and activation of the hypothalamus-pituitary-interrenal axis during temperature-induced sex reversal in pejerrey Odontesthes bonariensis, a species with genotypic and environmental sex determination., PMID:38008372
Predisposing factors for adrenal crisis in chronic adrenal insufficiency: a case-control study., PMID:38006230
A novel immune-related gene signature for predicting immunotherapy outcomes and survival in clear cell renal cell carcinoma., PMID:37919459
NR3C2 activates LCN2 transcription to promote endoplasmic reticulum stress and cell apoptosis in ischemic cerebral infarction., PMID:37832761
Functional mutation, splice, distribution, and divergence analysis of impactful genes associated with heart failure and other cardiovascular diseases., PMID:37798313
Hypercalcemia in patients with mutations in NR3C2 and SCNN1B., PMID:37596163
The genomic landscape of mammal domestication might be orchestrated by selected transcription factors regulating brain and craniofacial development., PMID:37552321
For research use only. Not for human or drug use.
